Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC

Document Type : Original Article

Authors

1 Internal Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

2 Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

3 Clinical Pathology Department -National Hepatology And Tropical Medicine Research

Abstract

Background:Hepatocellularcarcinoma(HCC)isthefifthmostcommonmalignancyinthe world.InEgypt,HCCwasreportedtoaccountforabout4.7%ofchronicliverdisease(CLD) patients.Squamouscellcarcinomaantigen(SCCA)hasbeenreportedtobestronglyexpressed inHCCtissuehamperingitsextensiveuseinclinicalpractice.
Aim:Studythevalueofserumsquamouscellcarcinomaantigen(SCCA)forscreeningof HCC.
Materials&Method:Thestudycomprisedoftwogroups.GroupAincluded60patientswith HCCdiagnosticallyconfirmedbyspiralCT,elevatedalfa-fetoprotein(AFP),and/orliverbiopsy .GroupBCLDpatientsdiagnosedonclinical,laboratory,andultrasonographicalinvestigations; groupBsuclassifiedintothreecategoriesaccordingtoCHILD-PUGHscoreincluded30 patients,matchedforsexandage.Allgroupsweresubjectedtothoroughhistorytaking,full clinicalexamination,andlaboratoryinvestigationsincludingliverfunctions,viralmarkers,and AFPandSCCAestimationusingELISAtechnique.
Results:ThisstudyrevealedahighlysignificantdifferencebetweenpatientswithHCCand CLDregardingserumSCCAlevelsbeinghigheringroupA(10.35±20.677)thangroup B(1.64±2.462)(p=0.02).SCCAlevelwaselevatedinpatientswithHCCwithnormalAFPlevels representingitsusefulroleinearlydetectionandfollow-upofpatientstreatedforHCC.The cut-offvaluewasestablishedat2ng/mlwithsensitivityof80%andspecificityof70%).
Conclusion:SCCAcouldrepresentausefultoolasamarkerfordetectionofHCC.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 39, Issue 1
April 2018
Pages 208-217

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