Abd Elatif, A., Abd Elreheem, S., Abd Elmegeed, A., Abd El Wahab, H. (2010). Anti-müllerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus. The Egyptian Journal of Hospital Medicine, 41(1), 502-514. doi: 10.21608/ejhm.2010.16949
Alshimaa A . Abd Elatif; Sabah I . Abd Elreheem; Amany M. E . Abd Elmegeed; Hoda Mahmoud Abd El Wahab. "Anti-müllerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus". The Egyptian Journal of Hospital Medicine, 41, 1, 2010, 502-514. doi: 10.21608/ejhm.2010.16949
Abd Elatif, A., Abd Elreheem, S., Abd Elmegeed, A., Abd El Wahab, H. (2010). 'Anti-müllerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus', The Egyptian Journal of Hospital Medicine, 41(1), pp. 502-514. doi: 10.21608/ejhm.2010.16949
Abd Elatif, A., Abd Elreheem, S., Abd Elmegeed, A., Abd El Wahab, H. Anti-müllerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus. The Egyptian Journal of Hospital Medicine, 2010; 41(1): 502-514. doi: 10.21608/ejhm.2010.16949
Anti-müllerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus
1Gynecology and obstetric Al Azhar University, Faculty of Medicine for Girls.
2Clinical pathology Al Azhar University, Faculty of Medicine for Girls.
3Radiodiagnostic Departments, Al Azhar University, Faculty of Medicine for Girls.
Abstract
Objective: To evaluate the different markers of ovarian reserve (AMH-Inhibin B , FSH and antral follicle count (AFC) in insulin dependent diabetes mellitus ( IDDM). Methods: We studied 30 patients with IDDM as study groups (10cases>32 years group IV and 20 cases 32 years group II) and 20 healthy women as control groups (8 cases >32 years group III and 12 cases 32 years group I . Serum levels of FSH, LH, inhibin B and AMH were measured at (days 1-7) of menstrual cycle and AFC was done by trans vaginal ultrasound. Results: AMH levels were lower in IDDM patients than in controls > 32 years (2.35 2.2 versus
7.79 difference in the levels of FSH .. AFC is valuable for the diagnoses of premature ovarian failure in IDDM.
1.73 p0.000). Also IDDM groups showed lower levels of inhibin B. While there is no
Conclusion: Compared with FSH (AMH and inhibin B) are more valuable for the diagnosis of premature ovarian aging in IDDM patients which developed earlier decline in the ovarian follicle pool compared with the healthy women and also AMH is more valuable than AFC for detection of premature ovarian failure in IDDM.
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