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Almaghrabi, A., Alghamdi, W., Almuyidi, S., Abuzaid, H. (2018). Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review. The Egyptian Journal of Hospital Medicine, 73(6), 6864-6869. doi: 10.21608/ejhm.2018.16936
Abdullah Talal Almaghrabi; Waleed Mohammed Alghamdi; Salah Mohammed Almuyidi; Hadil Hilal Abuzaid. "Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review". The Egyptian Journal of Hospital Medicine, 73, 6, 2018, 6864-6869. doi: 10.21608/ejhm.2018.16936
Almaghrabi, A., Alghamdi, W., Almuyidi, S., Abuzaid, H. (2018). 'Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review', The Egyptian Journal of Hospital Medicine, 73(6), pp. 6864-6869. doi: 10.21608/ejhm.2018.16936
Almaghrabi, A., Alghamdi, W., Almuyidi, S., Abuzaid, H. Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review. The Egyptian Journal of Hospital Medicine, 2018; 73(6): 6864-6869. doi: 10.21608/ejhm.2018.16936

Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review

Article 11, Volume 73, Issue 6, October 2018, Page 6864-6869  XML PDF (558.9 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.16936
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Authors
Abdullah Talal Almaghrabi1; Waleed Mohammed Alghamdi1; Salah Mohammed Almuyidi2; Hadil Hilal Abuzaid3
1University of Debrecen
2FacultyofMedicine,TaifUniversity
3AppliedSciencePrivate University
Abstract
Introduction: Studies supported the use of lipid lowering therapy such as statin as a treatment of
hypercholesterolemia for prevention of CHD. However, the use of lipid lowering therapy is not well
established in clinical practice due to lack of robust evidence and contra-indications in patients with
heart failure (HF). This review aimed at evaluating the evidence about preventive effect of lipid
lowering therapy on the mortality caused by coronary heart diseases. Methods: A comprehensive
electronic search was carried out using MEDLINE, EMBASE, Cochrane databases to identify articles
which aimed at assessing the preventive effect of lipid lowering therapy for coronary heart diseases.
The data were collected from included studies using data collection sheets using specific items such as
mean patient age, type of coronary disease, mean duration of the disease, drugs of lipid lowering
therapy, regime of lipid lowering therapy, duration of lipid lowering therapy, reduction in mortality
rate, and associated side effects. Results: Following evaluation of the eligible articles, 11 articles were
included with randomized controlled trials investigating the effect of lipid-lowering therapy on the
mortality of patient suffering from coronary heart diseases. The sample size in the included studies
ranged from 106 to 10355 participants, and the total number of participants among all included studies
were 50830 with mean age ranging from 31 to 82 years old. Conclusions: Despite the overall good
outcome that is attributed to the use of statins that is not clear weather this benefit is credited to its anti-
inflammatory or direct LDL lowering effect.
 
Keywords
Lipid; Therapy; Statin; Heart failure; myocardial infarction
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