Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)

Abd El-Gawwad, Hanaa A.; Abd El-Azez, Asmaa M.

doi:10.21608/ejhm.2021.165171

Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Al-Azhar University, Egypt

10.21608/ejhm.2021.165171

Abstract

Background: skeletal muscle relaxants contain a diverse mix of agents with different buildings and tools for achievement. These agents are classified as antispasmodics or antispasmodic agents, one of them is the drug carisoprodol.Objective: the current study aimed to investigate the possible effect of somadril compound on the skeletal muscle fibres and skin of fetuses maternally treated with carisoprodol.Material and methods: 30 pregnant female rats were categorized into 3 groups equal in number ten for each group, the first one (Control group ) ten pregnant female rats were administrated oral doses of distilled water; rats of the second group (S1) were administrated oral doses of carisoprodol in distilled water equivalent to 10.8 mg / 100 g body weight/ day and rats of the third group (S2) were administrated oral dose of carisoprodol in the distilled water equivalent to 21.6 mg /100g body weight/day. Rats of S1 and S2 were administrated oral dose of carisoprodol for 15 days from the 6^th day to the 20^th day of gestation. Many histological, histochemical and immunohistochemical studied were done to detect the alterations in the fetal skeletal muscles and skin. Results: fetal skin and skeletal muscle tissues of both treated groups showed many changes compared to the control group. Conclusion: treatment of the pregnant rats with carisoprodol led to numerous pathological changes in the fetal skin and skeletal muscle fibres.

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