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Fahmi, A., El-Desouky, M., El Gamal, M., El Gamal, M. (2011). Adiponectin and interlukin-10 in patients with liver diseases before and after liver transplantation. The Egyptian Journal of Hospital Medicine, 44(1), 318-324. doi: 10.21608/ejhm.2011.16411
Abdelgawad A. Fahmi; Mohamed A. El-Desouky; Mohamed M. El Gamal; Mohamed M. El Gamal. "Adiponectin and interlukin-10 in patients with liver diseases before and after liver transplantation". The Egyptian Journal of Hospital Medicine, 44, 1, 2011, 318-324. doi: 10.21608/ejhm.2011.16411
Fahmi, A., El-Desouky, M., El Gamal, M., El Gamal, M. (2011). 'Adiponectin and interlukin-10 in patients with liver diseases before and after liver transplantation', The Egyptian Journal of Hospital Medicine, 44(1), pp. 318-324. doi: 10.21608/ejhm.2011.16411
Fahmi, A., El-Desouky, M., El Gamal, M., El Gamal, M. Adiponectin and interlukin-10 in patients with liver diseases before and after liver transplantation. The Egyptian Journal of Hospital Medicine, 2011; 44(1): 318-324. doi: 10.21608/ejhm.2011.16411

Adiponectin and interlukin-10 in patients with liver diseases before and after liver transplantation

Article 6, Volume 44, Issue 1, July 2011, Page 318-324  XML PDF (408.15 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2011.16411
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Authors
Abdelgawad A. Fahmi1; Mohamed A. El-Desouky* 2; Mohamed M. El Gamal3; Mohamed M. El Gamal email 4
1Determents of Organic Chemistry Faculty of Science, Cairo University Egypt.
2Biochemistry Faculty of Science, Cairo University Egypt.
3Determents of Immunology and Microbiology, Military Medical Academy Egypt.
4Determents of Immunology and Microbiology, Military Medical Academy Egypt
Abstract
Background/Aims: Hepatitis C virus (HCV) infection is a global blood-borne disease with the highest prevalence in Egypt. This study was carried out to evaluate the prevalence of adiponectin, Interleukin-10 levels in liver diseases and to identify the potential role of adipocyte derived adiponectin in patients with end stage before and after liver transplantation.
 
Subject & method: The study population included 69 subjects classified as follow: Control group (G1) healthy individuals, group (G2) Anti HCV +ve & HCV RNA +ve by PCR, group (G3) Anti-HCV +ve &HCV RNA–ve by PCR and liver transplantation group (G4) patients underwent orthotropic liver transplantation; before liver transplantation (G4b) and after one week of liver transplantation (G4a).
 
Result: Adiponectin levels showed highly significant decrease in G2 (P <0.002), G3 showed insignificant decrease (P<0.6), G4b showed highly significant increased (P <0.0001) and G4a showed insignificant decrease (P<0.08) compared with control group G1. IL-10 levels showed highly significant increase in patients groups (G2, G3, G4b and G4a) as compared with control group (P<0.0001).
 
Conclusion: Adiponectin and IL-10 may be used as biomarker and/or a mediator of inflammatory states in liver diseases in patients with chronic hepatitis C. We suggest that high adiponectin and IL-10 levels in chronic liver disease before liver transplantation might reflect one of the body’s anti-inflammatory mechanisms in chronic liver diseases.
 
 
Keywords
Chronic hepatitis C; Hepatitis C virus; adiponectin; Interleukin-10; Liver transplantation
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