Fadel, H., Hassanin, E., Rihan, Z., Abd Allah, E. (2012). Comparative studies on the effect of some antioxidants on renal dysfunction in rats. The Egyptian Journal of Hospital Medicine, 46(1), 115-131. doi: 10.21608/ejhm.2012.16364
Hewaida A.E. Fadel; Essayed A. Hassanin; Zakaria E. Rihan; Eveleen S. Abd Allah. "Comparative studies on the effect of some antioxidants on renal dysfunction in rats". The Egyptian Journal of Hospital Medicine, 46, 1, 2012, 115-131. doi: 10.21608/ejhm.2012.16364
Fadel, H., Hassanin, E., Rihan, Z., Abd Allah, E. (2012). 'Comparative studies on the effect of some antioxidants on renal dysfunction in rats', The Egyptian Journal of Hospital Medicine, 46(1), pp. 115-131. doi: 10.21608/ejhm.2012.16364
Fadel, H., Hassanin, E., Rihan, Z., Abd Allah, E. Comparative studies on the effect of some antioxidants on renal dysfunction in rats. The Egyptian Journal of Hospital Medicine, 2012; 46(1): 115-131. doi: 10.21608/ejhm.2012.16364
Comparative studies on the effect of some antioxidants on renal dysfunction in rats
1Department of Nutritional Chemistry& Metabolism, National Nutrition `Institute
2Department of Endocrinology, Military Medical academy
3Department of Home Economies, Ain Shams Univerersity
Abstract
The present study is carrying out for investigating the effect of supplementation with some vitamins (A, E&C) as natural antioxidant extracts in renal dysfunction in rates. Material& Methods: 40 adult male Sprague – Dawley rats (150 – 200 g) divided to two groups. First group: 8 rats were fed on standard diet (S.D.), as a control group. Second group: 32 rats were injected intraperitonial with a single dose of Cis-diammine dichloride Platinum II (CDDP) for inducing renal dysfunction (2.5 mg/Kg) then it was divided to six subgroups each one contained 8 rats. (1): fed on (S.D.) nephrotoxic group. (2): fed on (S.D.) + Vitamin A (15 mg/Kg body weight/day). (3): fed on (S.D.) + Vitamin E (317 I.U. /kg body weight/day). (4): fed on (S.D.) + Vitamin C (280 I.U. /kg body weight/day). The experimental period was four weeks, results were statistically analyzed. Results: The results proved that groups of nephrotoxicity rats supplemented with Vitamin A,E and C showed significant increase in food intakes, body weight gain and food efficiency ratio (FER) (28.9%, 29.4% and 19.2%), (870.5%, 1615.6% and 409.8%) and (652.5%, 122502% and 327.3%) respectively, compared with nephrotoxic group. The nephrotoxicity rats supplemented with Vitamin A and showed significant reduction in serum vitamin E &kidney glutathione content (9.3% & 47.9%), while nephrotoxicity rats supplemented with Vitamin E&C showed significant increase in serum vitamin E &kidney glutathione content (27.9% & 116.6%), (13.7%&55.8%)respectively. The results showed that nephrotoxicity rats supplemented with Vitamin A,E and C showed significant reduction in serum urea nitrogen and creatinine (48.01% and 55.2%), (52.6% and 60.3%) and (57.0% and 63.04%) respectively. Best results in histopathological examination of kidney were in vitamin A and vitamin C groups. Conclusion: These results suggest that natural antioxidants could be beneficial as additional therapy in renal dysfunction.
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