Curative Effect of Bone Marrow Cells Transplantation and/or Low Dose Gamma Irradiation on Liver Injuries Induced by Carbon Tetrachloride

Zowail, Mohamed E.M.; Khater, Eman H. S.; Waer, Hanaa F. M.; Eltahawy, Noaman A.; Abd El-hady, Amr M.

doi:10.21608/ejhm.2012.16362

Curative Effect of Bone Marrow Cells Transplantation and/or Low Dose Gamma Irradiation on Liver Injuries Induced by Carbon Tetrachloride

Document Type : Original Article

Authors

¹ Faculty of Science, Benha University

² National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo,

³ Faculty of Applied Medical Sciences, Misr University for Science and Technology.

10.21608/ejhm.2012.16362

Abstract

Liver is the most common target for toxic injury. Toxic agents include chemicals such as carbon tetrachloride (CCl₄) and trichloroethylene. This study aimed to evaluate the effect of bone marrow cells (BMC) transplantation and/or fractionated low doses (0.5 Gy) gamma radiation on established liver fibrosis induced by CCl₄. BMCs of male albino rats were transplanted into 4-weeks carbon tetrachloride (CCl₄)–treated and/or fractionated low doses (0.5 Gy) gamma irradiated rats through the tail vein, and the rats were treated for 4 more weeks with CCl₄ (total 8 weeks). Histological and ultrastructural investigations revealed that both bone marrow cells transplantation and low dose (0.5 Gy) gamma radiation exposure with continuous CCl₄ injection had reduced liver fibrosis as compared with rats treated with CCl₄ alone.