Abd El-Hakeem, E., Aly, A., Mahmoud, O., Darweesh, E., Hassan, A. (2021). Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?. The Egyptian Journal of Hospital Medicine, 83(1), 1142-1148. doi: 10.21608/ejhm.2021.160888
Essam Ezzat Abd El-Hakeem; Ahmed Elsaied Abd Elrahman Aly; Osama Salah El Din Mahmoud; Eman Ebraheem Darweesh; Ahmad Hamody Hassan. "Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?". The Egyptian Journal of Hospital Medicine, 83, 1, 2021, 1142-1148. doi: 10.21608/ejhm.2021.160888
Abd El-Hakeem, E., Aly, A., Mahmoud, O., Darweesh, E., Hassan, A. (2021). 'Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?', The Egyptian Journal of Hospital Medicine, 83(1), pp. 1142-1148. doi: 10.21608/ejhm.2021.160888
Abd El-Hakeem, E., Aly, A., Mahmoud, O., Darweesh, E., Hassan, A. Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?. The Egyptian Journal of Hospital Medicine, 2021; 83(1): 1142-1148. doi: 10.21608/ejhm.2021.160888
Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?
Background: During coronary artery bypass grafting (CABG), the myocardium is subjected to endure periods of ischemia and reperfusion, which may result in post-ischemic contractile dysfunction. That is a major contributor to early and late morbidity and mortality and increased requirement of pharmacologic and mechanical circulatory support.Glucose insulin potassium (GIK) infusion was thought to provide a cardioprotective effect. Objective: To investigate whether the use of GIK solution in patients undergoing on-pump CABG affects requirements of inotropes. Patients and Method: In this prospective, randomized placebo-controlled trial, 64 patients were assigned into two groups: the GIK group in which glucose-insulin and potassium infusion was given during CABG surgery, and the non-GIK group in which only saline infusion was given during the procedure. Results: In the GIK group, all patient needed not more than two inotropes with mean of 1.28 ± 0.46, while in the non-GIK group there were patients who need up to three inotropes with mean of 1.56 ± 0.56 (P. value of 0.032). Conclusion: GIK infusion during on-pump CABG reduces perioperative inotropic requirements.