Evaluation of Some Biochemical Changes in Diabetic Patients

.El-desoky, M.A; Amin, A.E.; .El-refai, M.O; Farid, R.J.; Labib, A.A.

doi:10.21608/ejhm.2018.16084

Evaluation of Some Biochemical Changes in Diabetic Patients

Document Type : Original Article

Authors

¹ Department of Chemistry,Biochemistry Division, Faculty of Science, Cairo University.

² Department of Clinical Pathology, Faculty of Medicine, Cairo University

³ M.Sc candidate, Faculty of Science, Cairo University

10.21608/ejhm.2018.16084

Abstract

Patients and methods: The present study consisted of 50 subjects were classified into three groups ;
Group (GI) Control group consisted of 10 clinically healthy adult subjects of both sexes free from any liver , kidney or cardiovascular diseases .
Group (GII) diabetes mellitus type 1 consisted of 20 patients of both sexes.
Group (GIII) diabetes mellitus type 1 with nephropathy consisted of 20 patients of both sexes . All subjects were undergo to the following investigated parameters; Ascorbic acid (vitamin C) ,Catalase ,Total antioxidant capacity, Aldolase and Pyruvate kinase enzyme.
Results: vitamins C, catalase, total antioxidant capacity enzymes were highly significant decreased (P < 0. 01) in diabetes mellitus type 1 (GII) and diabetes mellitus type 1 with nephropathy (GIII) when compared to the control group. Adolase activity washighly significant increased (P < 0. 01) in diabetes mellitus type 1 with nephropathy (GIII) when compared to the control group . Pyruvate Kinase activitywashighly significant increased (P < 0. 01) in diabetes mellitus type 1 (GII) when compared to the control group .
Conclusion: The antioxidant and enzymes can be used for follow up in patients suffering from diabetes mellitus type 1 and predict other complications.

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