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Shousha, W., El-Haddad, O., Basuni, A., El-Mezayen, H., Abdalla, A. (2013). Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients. The Egyptian Journal of Hospital Medicine, 51(1), 326-331. doi: 10.21608/ejhm.2013.15983
Wafaa Gh. Shousha; OM Kolsoum El-Haddad; Ashraf A. Basuni; Hatem A. El-Mezayen; Amany A. Abdalla. "Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients". The Egyptian Journal of Hospital Medicine, 51, 1, 2013, 326-331. doi: 10.21608/ejhm.2013.15983
Shousha, W., El-Haddad, O., Basuni, A., El-Mezayen, H., Abdalla, A. (2013). 'Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients', The Egyptian Journal of Hospital Medicine, 51(1), pp. 326-331. doi: 10.21608/ejhm.2013.15983
Shousha, W., El-Haddad, O., Basuni, A., El-Mezayen, H., Abdalla, A. Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients. The Egyptian Journal of Hospital Medicine, 2013; 51(1): 326-331. doi: 10.21608/ejhm.2013.15983

Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients

Article 15, Volume 51, Issue 1, April 2013, Page 326-331  XML PDF (390.16 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2013.15983
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Authors
Wafaa Gh. Shousha1; OM Kolsoum El-Haddad2; Ashraf A. Basuni3; Hatem A. El-Mezayen1; Amany A. Abdalla1
1Chemistry Department, Helwan University, Egypt
2Clinical Hepatology Department, Menofiya University, Egypt
3Clinical Biochemistry Deparment, Menofiya University, Egypt
Abstract
Retinol-binding protein 4 (RBP4) has been identified as a protein contributing to insulin resistance (IR). As insulin resistance is present in nearly all patients with liver cirrhosis, we evaluated RBP4 in patients with chronic hepatitis C virus infected patients (CHC). This study aimed to evaluate the role of serum retinol binding protein 4 (RBP-4) as a predictor for early detection of insulin resistance (IR) in patients with CHC infection.
Research Design and Methods: Serum RBP4 was measured in 60 non diabetic CHC Patients classified according to Child- Pugh classification (Child A, Child B, Child C), 20 diabetic CHC patients and 20 age- and sex-matched healthy blood donors served as control subjects. RBP-4 correlation with the homeostasis model assessment of insulin resistance index (HOMA-IR) and metabolic factors was investigated.
 Results: Serum RBP-4 levels were significantly lower in HCV infected patients and HCV diabetic patients compared with controls (HCV 16545.17± 10633.16, Diabetic HCV 10310 ± 4371.31, Control 27820.0 ± 9316.46, P< 0.001). In addition, serum levels of RBP-4 significantly decreased between all stages of cirrhosis, with the lowest level in Child C. HOMA-IR not significantly higher in HCV infected patients compared to control (HCV 5.54 ± 3.67, and Control 4.11 ± 2.42). RBP-4 levels correlate positively with GGT (P<0.01), CHOL (P<0.05) and TG (P<0.05) in HCV Child C, additionally, it shows significant positive correlation with TG (P< 0.05) in HCV Child B. 
Conclusions: Disease severity may limit the role of RBP4 as a predictor of IR in CHC. These data demonstrate that RBP4 in CHC patients decreased due to reduced hepatic production, and it is not associated with insulin resistance.
Keywords: HCV, RBP4, Insulin Resistance
Abbreviations: RBP4: Retinol-binding protein 4, IR: insulin resistance, HOMA-IR: homeostasis model assessment of insulin resistance index, CHC: Chronic Hepatitis C Virus.
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