The Effect of Lupinus Albus (Termis) and Hyphaene Thebaica (Doum) on Some Biochemical Parameters in Streptozotocin-Induced Diabetic Rats

Tohamy, Amany A; Mohammed, Rasha S; Abdalla, Mohga S; Ibrahim, Adel K; Mahran, Khaled F

doi:10.12816/0001640

The Effect of Lupinus Albus (Termis) and Hyphaene Thebaica (Doum) on Some Biochemical Parameters in Streptozotocin-Induced Diabetic Rats

Document Type : Original Article

Authors

¹ Department of zoology and entomology, Faculty of science, Helwan University

² Department of chemistry, Faculty of science, Helwan University

³ Department of clinical pathology, Veterinary Medicine, Cairo University.

10.12816/0001640

Abstract

Background: Several plants have been used as dietary adjuvant and in treating the number of diseases because of their perceived effectiveness, minimal side effects in clinical experience and relatively low costs.The present study focuses on evaluating the effect of Lupinus albus (termis) and Hyphaene thebaica (doum) on STZ-diabetic rats at the level of some biochemical parameters Material and methods: STZ was injected intraperitoneally at a single dose of 50 mg/kg to induce diabetes. Termis seeds suspension (75 mg/100 g b.wt.) was daily orally administered. Doum palm fruit suspension was daily orally administered (1g/kg b.wt.) and also gliclazide (reference drug) was administered of a dose equivalent to the therapeutic dose of rat. After four weeks of administration, blood samples were collected for biochemical measurement. Results: Blood glucose level was significantly increased. Diabetes increased serum total lipids, cholesterol, triglycerides and LDL but serum HDL wasdecreased. Also activities of serum enzymes ASAT, ALAT, ALP, GGT and LDH were elevated. However, L. albus and H. thebaica improved the level of mostly all biochemical parameters.
Conclusion: It is concluded that termis and doum may be dietary adjuvant in reducing the harmful of diabetes.

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