Amer, M., Farid, T., Abdel-rahman, E., EL-maleh, D., Omar, O., Mabrouk, R. (2014). Relationship between Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among Frail Elderly. The Egyptian Journal of Hospital Medicine, 55(1), 137-141. doi: 10.12816/0004498
Moatassem S. Amer; Tamer M. Farid; Ekrami E. Abdel-rahman; Deena M. EL-maleh; Omar H. Omar; Randa A. Mabrouk. "Relationship between Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among Frail Elderly". The Egyptian Journal of Hospital Medicine, 55, 1, 2014, 137-141. doi: 10.12816/0004498
Amer, M., Farid, T., Abdel-rahman, E., EL-maleh, D., Omar, O., Mabrouk, R. (2014). 'Relationship between Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among Frail Elderly', The Egyptian Journal of Hospital Medicine, 55(1), pp. 137-141. doi: 10.12816/0004498
Amer, M., Farid, T., Abdel-rahman, E., EL-maleh, D., Omar, O., Mabrouk, R. Relationship between Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among Frail Elderly. The Egyptian Journal of Hospital Medicine, 2014; 55(1): 137-141. doi: 10.12816/0004498
Relationship between Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among Frail Elderly
1Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo
2Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Frailty may now be regarded as a geriatric syndrome of decreased reserve and resistance to stressors, resulting from cumulative declines across multiple physiologic systems, causing vulnerability to adverse health outcomes including falls, hospitalisation, institutionalisation and mortality. The inflammatory mediators as C-reactive protein have been associated with the development of the geriatric frailty. Several studies have pointed out increased level of homocystiene in frail elderly Increasing frailty was associated with lower bone mineral density, as both bone mass and muscle strength decrease during ageing and this has also been associated with higher risk of osteoporotic fractures in frail elderly. Objective: To compare frail and non-frail elderly regarding Bone mineral density, carotid circulation and serum levels of Homocysteine, coronary risk factors and CRP. Methods: 104 elderly patients, who were assigned to 2 groups. Group A (52 frail participants): diagnosed by Fried’s criteria as applied by Avila-Funes et al., 2008. Group B (52 non-frail participants).All participants were subjected to the following: through history, physical examination, ADL, IADL assessment, MMSE ,GDS, laboratory investigations including; CRP, homocystiene and total lipid profile, measurement of bone mineral density by DEXA and carotid intima-media thickness by carotid duplex. Results: There was no statistically significant difference in age, sex, among both groups.Frail participants had higher ADL and IADL dependence, higher incidence of depression, cognitive impairment and osteoprosis.They also had higher levels of homocystiene , CRP , CIMT and lower levels of HDL cholesterol. Conclusion: Osteoporosis is more prevalent among frail elderly also frailty is associated with more ADL & IADL dependence, higher GDS scores & lower MMSE score in addition to higher mean level of homocystiene, CRP & triglycerides in addition to low serum HDL & higher CIMT.
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