Youssef, G. (2016). Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.. The Egyptian Journal of Hospital Medicine, 62(1), 105-108. doi: 10.12816/0021419
Gehan A. Youssef. "Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.". The Egyptian Journal of Hospital Medicine, 62, 1, 2016, 105-108. doi: 10.12816/0021419
Youssef, G. (2016). 'Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.', The Egyptian Journal of Hospital Medicine, 62(1), pp. 105-108. doi: 10.12816/0021419
Youssef, G. Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.. The Egyptian Journal of Hospital Medicine, 2016; 62(1): 105-108. doi: 10.12816/0021419
Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.
Physiology Department , Faculty of Medicine (Girls), Al-Azhar University.
Abstract
Background Ginseng, an ancient and famous medicinal herb in the Orient, has been used as a valuable tonic and for the treatment of various diseases including hepatic disorders. Ginseng extracts and individual ginsenosides have shown a wide array of beneficial role in the regulation of regular liver functions and the treatment of liver disorders. Objective: This study tries to determine the hepatoprotective , antioxidant and anti-inflammatory effects of ginseng on Methotrexate (MTX)-induced hepatotoxicity Materials and Methods: forty rats (weigh 150-180 g) were used. The rats were kept in animal house for one week and had access to water and food . Temperature was kept at 37 °C. After one week, the rats were randomly divided into four equal groups: Group (A) (control) received normal saline ; group (B )received Ginseng(1.8 ml/kg/day) orally ; group( C) received MTX (100 μg/kg) intraperitoneally and group (D) received MTX (100 μg/kg) intraperitoneally with ginseng (1.8 ml/kg/day) orally. After six weeks, the rats were decapitated and evaluation of liver function was done. Results: Ginseng treatment markedly suppressed the serum alanine aminotransferase (ALT) , aspartate aminotransferase (AST) and serum gama glutamil transpeptidase (λGTP) activiteis . Ginseng was attributed to stimulate anti-oxidant protein contents, such as glutathione peroxidase (GPX). The marked increase of proinflammatory cytokines ( TNF α ) in MTX treated rats group was additionally attenuated by ginseng, Conclusion : Ginseng effectively prevent liver injury, mainly through down regulation of oxidative stress and inflammatory response.
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