A. S, A., B. N, H., N. A, A. (2016). Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat. The Egyptian Journal of Hospital Medicine, 62(1), 28-36. doi: 10.12816/0021411
Alazzouni A. S; Hassan B. N; Al Jalaud N. A. "Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat". The Egyptian Journal of Hospital Medicine, 62, 1, 2016, 28-36. doi: 10.12816/0021411
A. S, A., B. N, H., N. A, A. (2016). 'Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat', The Egyptian Journal of Hospital Medicine, 62(1), pp. 28-36. doi: 10.12816/0021411
A. S, A., B. N, H., N. A, A. Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat. The Egyptian Journal of Hospital Medicine, 2016; 62(1): 28-36. doi: 10.12816/0021411
Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat
1Department of Zoology, Faculty of Science, Helwan University
2Department of Biology, Faculty of Science, University of Dammam, Saudi Arabia
Abstract
Background: Bisphenol A (BPA) is an environmental chemical that has beenwidely used in the manufacture of polycarbonate plastics andepoxy resins for many years. Due to its major applications inthe production of plastic food or beverage containers andthe coating of food cans, people of different ages are inevitably exposed to BPA in daily life. It is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells. Aim of the work: the present study was designated to evaluate the histopathological and immunohistochemical effect of BPA on the histoarchitecture of pituitary ,adrenal,ovarian and uterine axis of female albino rats and the ameliorative effect of antiestrogen drug and stem enhance Experimental model and methods: 20 female albino rats weighing 100 – 120 g. were kept under observation for about 15 days before the onset of the experiment for adaptation, then the rats were classified into 4 groups 5 rats for each , the first group was left without any treatment for 30 days as negative control group , the second group was administered with 20 mg/kg.bw of BPA for 15 consecutive days as positive control, the third group administered with 20 mg/kg.bw of BPA for 15 consecutive days and then treated withantiestrogen drug as 0.1 mg/100gm.bw for 15 day, the fourth group administered with the same dose for the same period and the treated with stem enhance (4.5 mg/100.bw) for 15 days.All rats are scarified and organs were histologically examined after processing Results:the results showed thatPA has a histopathological effects on vital organs (pituitary, adrenal,ovary,oviduct and uterus) even for a short period with minimal ameliorative effect of antiestrogen drug and stem enhance.
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