Hanafy, Z., Eldawy, H., Mahrous, K., Mohamed, A. (2016). Role of Quercetin against 2-Butoxyethanol Induced Micronucleus and Chromosome Aberrations in Mice. The Egyptian Journal of Hospital Medicine, 64(1), 311-318. doi: 10.12816/0029023
Zeinab Eid Madboly Hanafy; Hassan Abd El sattar Eldawy; Karima Fathi Mahrous; Asmaa Kutb Mohamed. "Role of Quercetin against 2-Butoxyethanol Induced Micronucleus and Chromosome Aberrations in Mice". The Egyptian Journal of Hospital Medicine, 64, 1, 2016, 311-318. doi: 10.12816/0029023
Hanafy, Z., Eldawy, H., Mahrous, K., Mohamed, A. (2016). 'Role of Quercetin against 2-Butoxyethanol Induced Micronucleus and Chromosome Aberrations in Mice', The Egyptian Journal of Hospital Medicine, 64(1), pp. 311-318. doi: 10.12816/0029023
Hanafy, Z., Eldawy, H., Mahrous, K., Mohamed, A. Role of Quercetin against 2-Butoxyethanol Induced Micronucleus and Chromosome Aberrations in Mice. The Egyptian Journal of Hospital Medicine, 2016; 64(1): 311-318. doi: 10.12816/0029023
Role of Quercetin against 2-Butoxyethanol Induced Micronucleus and Chromosome Aberrations in Mice
1Zoology Department, Faculty of Science, Al–Azhar University (Girls)
2Radiation biology Department, National Center for Radiation Research and Technology
3Cell biology Department,National research center.
Abstract
EGBE is also known as 2-butoxyethanol (2BE). EGBE is widely used as a solvent in various applications, such as in surface coatings, spray lacquer, quick-dry lacquers, enamels, varnishes, varnish removers, latex paint, metal cleaners, and in commercially available cleaning products. 2-Butoxyethanol causes cellular damage via formation of reactive oxygen species. Quercetin, a flavonol group of plant flavonoid, has generated interest because of its potential antioxidant, anti-proliferative, chemoprotective and anti-inflammatory properties. Quercetin exhibited significant antimutagenic and DNA-protective effects against oxidative damage due to the presence of hydroxyl groups in the molecule; it is considered an excellent free radical scavenging antioxidant owing to the high number of hydroxyl groups. Materials and Methods: 2BE was given orally to male mice for seven days at two doses (450µl &900µl/kg b.w.). Quercetin was dissolved in corn oil. The animals in positive control group were treated with only corn oil. Quercetin (20 mg/kg b.w.) was administered orally for 7 days prior to 7 days treatment of 2BE for the two doses. Quercetin (20 mg/kg b.w.) was also administered for 14 days (7 days before and 7 days during the period of treatment with two doses of 2BE). Result: the two doses of 2BEinduced both micronuclei (2.88% and 12.77%) and chromosomal aberration in (50% & 72.8%, respectively) of cells. Quercetin administration lowered the frequency of micronuclei and chromosome aberration. Conclusion: These effects of quercetin are to be taken into consideration while evaluating the possible use of quercetin as a protective agent.
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