Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 99 (2025)
Volume Volume 98 (2025)
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Abd Alsalam, A., Elshaer, F., Mansour, H. (2016). Assessment of the Potential role of Hesperidin as an Antioxidant on the Carbon Tetrachloride -Induced Kidney Damage in Rats. The Egyptian Journal of Hospital Medicine, 64(1), 277-286. doi: 10.12816/0029020
Ali Abd Alsalam; Fathy M. Elshaer; Hamdi Abdou Mansour. "Assessment of the Potential role of Hesperidin as an Antioxidant on the Carbon Tetrachloride -Induced Kidney Damage in Rats". The Egyptian Journal of Hospital Medicine, 64, 1, 2016, 277-286. doi: 10.12816/0029020
Abd Alsalam, A., Elshaer, F., Mansour, H. (2016). 'Assessment of the Potential role of Hesperidin as an Antioxidant on the Carbon Tetrachloride -Induced Kidney Damage in Rats', The Egyptian Journal of Hospital Medicine, 64(1), pp. 277-286. doi: 10.12816/0029020
Abd Alsalam, A., Elshaer, F., Mansour, H. Assessment of the Potential role of Hesperidin as an Antioxidant on the Carbon Tetrachloride -Induced Kidney Damage in Rats. The Egyptian Journal of Hospital Medicine, 2016; 64(1): 277-286. doi: 10.12816/0029020

Assessment of the Potential role of Hesperidin as an Antioxidant on the Carbon Tetrachloride -Induced Kidney Damage in Rats

Article 3, Volume 64, Issue 1, July 2016, Page 277-286  XML PDF (747.17 K)
Document Type: Original Article
DOI: 10.12816/0029020
View on SCiNiTO View on SCiNiTO
Authors
Ali Abd Alsalam email 1; Fathy M. Elshaer2; Hamdi Abdou Mansour3
1Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
2Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
3Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo Egypt
Abstract
Aim of the work-The present work aimed to investigate the ability of Hesperidine (HDN) as an antioxidant to retard development of renal toxicity induced by CCL4 in rat. Hesperidin (HDN), a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat kidney. Exposure to CCl4 induces acute and chronic renal injuries. The present study was designed to evaluate the protective effect of hesperidin, on rat kidney damaged by CCl4. Material and methods- Animals were divided into five groups pretreated with hesperidin (HDN) (100 and 200 mg/kg orally) for 10 days and then challenged with CCl4 (2 ml/kg/s.c.) of in olive oil subcutaneously. Rats were sacrificed by carotid bleeding under ether anesthesia. Results: The present results showed that the antioxidant properties of hesperidine might be the main factor responsible for its strong protective action on CCl4-induced nephrotoxicity. Conclusion- This study proved that hesperidin has a protective effect on the renal tissue of rat and the degree of improvement varies in intensity according the dose of Hesperidin
 
Keywords
Hesperidin; Carbon tetrachloride; kidney; albino rat
Statistics
Article View: 193
PDF Download: 343