Amelioration of Insulin Resistance in Rats Treated with Rice Bran Oil

Abd Elbast, Sohaier, A.; Ahmed, Mervat, A.; Ahmed, Elham, A.; Rashed, Laila, A.; Mohamed, Mona, A.

doi:10.12816/0033763

Amelioration of Insulin Resistance in Rats Treated with Rice Bran Oil

Document Type : Original Article

Authors

¹ Zoology Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt

² Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt

³ Biochemistry Unit, Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt

10.12816/0033763

Abstract

Background: insulin resistance (IR) is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. It plays pathophysiological role in type 2 diabetes mellitus (T2DM). High dosage of fructose in the diet (60 g/100 g diet) may induce insulin resistance accompanied by deleterious metabolic consequences including hyperglycemia and hyperinsulinemia. Rice bran oil (RBO), is a rich source of antioxidants especially γ-oryzanol, α-tocopherols and tocotrienols which contribute to high oxidative stability, longer shelf life than other edible oils and high antioxidant property against free radicals. The present work was undertaken to study if the addition of rice bran oil in rat’s diets ameliorate the insulin resistance.
Materials and methods: to achieve this target, plasma fasting glucose, serum insulin and calculated HOMA-IR, which assesse the presence of insulin resistance, was evaluated. Serum lipid profile (cholesterol, triglycerides, high-density lipoprotein- cholesterol (HDL) and low-density lipoprotein- cholesterol (LDL) was also evaluated. In addition, the oxidative stress was assessed through hepatic malondialdehyd (MDA) as an oxidative biomarker and the antioxidant enzyme superoxide dismutase (SOD) was also estimated.
Results: RBO ameliorated HOMA-IR, oxidative biomarker (MDA) and increased SOD activity.
Conclusion: high fructose diet induced oxidative stress which lead to insulin resistance, this was ameliorated by addition of RBO.

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