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Helal, E., Taha, N., mohamed, A., Abu-Taleb, H. (2016). Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats. The Egyptian Journal of Hospital Medicine, 65(1), 474-478. doi: 10.12816/0033755
Eman Helal; Neama M. Taha; Ahmed M. mohamed; Hoda M. Abu-Taleb. "Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats". The Egyptian Journal of Hospital Medicine, 65, 1, 2016, 474-478. doi: 10.12816/0033755
Helal, E., Taha, N., mohamed, A., Abu-Taleb, H. (2016). 'Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats', The Egyptian Journal of Hospital Medicine, 65(1), pp. 474-478. doi: 10.12816/0033755
Helal, E., Taha, N., mohamed, A., Abu-Taleb, H. Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats. The Egyptian Journal of Hospital Medicine, 2016; 65(1): 474-478. doi: 10.12816/0033755

Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats

Article 3, Volume 65, Issue 1, October 2016, Page 474-478  XML PDF (299.63 K)
Document Type: Original Article
DOI: 10.12816/0033755
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Authors
Eman Helal email orcid 1; Neama M. Taha2; Ahmed M. mohamed3; Hoda M. Abu-Taleb4
1AlAzhar univ.
2Physiology Department, College of Medicine
3Clinical Pharmacology Department, Faculty Of Medicine, Zagazig University
4Department of Environmental Research, Theodor Bilharz Research Institute, Cairo, Egypt.
Abstract
Objective: Oxidative stress is induced by bisphenol A (BPA) and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA.
Materials and methods: 30 female albino rats were divided into 3 groups (10/each); group1: control rats, group 2: rats treated with bisphenol A (20 mg/ kg.B.wt) for three months, and group 3: rats treated with bisphenol A (20 mg/kg.B.wt) for three months, then treated with BPA and vitamin E (0.57/100 g B.wt) for other 15 days. Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters. Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent.
 
Keywords
BPA; Vitamin E; sexual hormone; Liver; kidney; lipids
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