Effect of Endotoxemia on Cardiac Disease in High & Low Flux Hemodialysis Patients

Document Type : Original Article

Authors

Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

10.12816/0018765

Abstract

  Background :  endotoxemia  can  be  the  missing  link  between  ESRD  and  cardiac  disease , the  first  cause  of  death  in  hemodialysis  patients .
 Patients  and  methods : patients  were  recruited  from  Ain  Shams  University  Hospitals , hemodialysis units  .120  patients  on  prevalent  HD  were  enrolled  in  the  study : 31  cardiac patients  on  high  flux  HD (  group A) , 29  cardiac  patients  on  low  flux  HD  (group B), 32  non – cardiac  high  flux  HD  ( group C), and  28  non – cardiac  low  flux  HD  ( group  D) . For  all  patients  we  measured :  Hb  , URR , serum  albumin ,  HsCRP,  predialysis   and  postdialysisa  endotoxin ,  endotoxin  delta  change,  echocardiography , and  ECG . Results : we  found  that  cardiac  high  flux  and  low  flux  groups  had  higher  endotoxemia  levels  than  non – cardiac  high  flux  and  low  flux  groups .Conclusion  : High  flux  hemodialysis  patients  had  higher  accumulated  endotoxin  than  low  flux  hemodialysis  patients, within  either   cardiac  or  non - cardiac  groups .
 

Keywords

The Egyptian Journal of Hospital Medicine
Volume 61, Issue 1
October 2015
Pages 620-630

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