El-Ganzuri, M., Khalifa, A., Helal, T., Rizk, N., Al-Jalaud, N. (2015). In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus. The Egyptian Journal of Hospital Medicine, 61(1), 459-478. doi: 10.12816/0018751
Monir A. El-Ganzuri; Ali Khalifa; Thanaa Helal; Nanice Nabil Rizk; Nora A. Al-Jalaud. "In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus". The Egyptian Journal of Hospital Medicine, 61, 1, 2015, 459-478. doi: 10.12816/0018751
El-Ganzuri, M., Khalifa, A., Helal, T., Rizk, N., Al-Jalaud, N. (2015). 'In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus', The Egyptian Journal of Hospital Medicine, 61(1), pp. 459-478. doi: 10.12816/0018751
El-Ganzuri, M., Khalifa, A., Helal, T., Rizk, N., Al-Jalaud, N. In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus. The Egyptian Journal of Hospital Medicine, 2015; 61(1): 459-478. doi: 10.12816/0018751
In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus
1Zoology department, Faculty of Science, Ain Shams University
2Biochemistry department and Head of Oncology Diagnostic unit . Faculty of Medicine, Ain Shams University
3Pathology department, Faculty of Medicine, Ain Shams University
4Department of Biology,Faculty of Science,Dammam University,Saudi Arabia
Abstract
Aim of the work-In Egypt cervical carcinoma is ranked as a number 6 of all malignant tumors. There is growing evidence that the human papillomavirus (HPV) is associated with the development of cervical cancer. Patients and Methods-The present study hunted HPV in Egyptian biopsies of cervical cancer by using in situ hybridization (ISH) technique .Light microscopy and ultra-structural features accompanied by squamous cell carcinoma (SCC) of the cervix were monitored. Results-The ultra structural study revealed viral particles in some epithelial cell nuclei and cytoplasm in the moderately-differentiated squamous cell carcinoma. These were suggested to be Herpes Simplex Virus (HSV). Conclusion-The potential relation between HPV and HSV in the incidence of Cervical Squamous Cell Carcinoma is discussed.
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