In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus

El-Ganzuri, Monir A.; Khalifa, Ali; Helal, Thanaa; Rizk, Nanice Nabil; Al-Jalaud, Nora A.

doi:10.12816/0018751

In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus

Document Type : Original Article

Authors

¹ Zoology department, Faculty of Science, Ain Shams University

² Biochemistry department and Head of Oncology Diagnostic unit . Faculty of Medicine, Ain Shams University

³ Pathology department, Faculty of Medicine, Ain Shams University

⁴ Department of Biology,Faculty of Science,Dammam University,Saudi Arabia

10.12816/0018751

Abstract

Aim of the work-In Egypt cervical carcinoma is ranked as a number 6 of all malignant tumors. There is growing evidence that the human papillomavirus (HPV) is associated with the development of cervical cancer. Patients and Methods-The present study hunted HPV in Egyptian biopsies of cervical cancer by using in situ hybridization (ISH) technique .Light microscopy and ultra-structural features accompanied by squamous cell carcinoma (SCC) of the cervix were monitored. Results-The ultra structural study revealed viral particles in some epithelial cell nuclei and cytoplasm in the moderately-differentiated squamous cell carcinoma. These were suggested to be Herpes Simplex Virus (HSV). Conclusion-The potential relation between HPV and HSV in the incidence of Cervical Squamous Cell Carcinoma is discussed.

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