Effects of High Flux versus Low Flux on Serum C-Reactive Protein A as an Inflammatory Biomarker in Hemodialysis Patients

Mohamed, Emad Allam; Mohamed, Magdy Elsayed; Abdelhamid, Haytham Sabry; Mohammed, Mohammed Al-Arabi

doi:10.12816/0037816

Effects of High Flux versus Low Flux on Serum C-Reactive Protein A as an Inflammatory Biomarker in Hemodialysis Patients

Document Type : Original Article

Authors

Nephrology Unit, Faculty of Medicine, Al-Alzhar Universit.

10.12816/0037816

Abstract

Background: Traditional low-flux dialysis cannot improve micro-inflammatory status, while new high-flux dialysis can improve the micro-inflammation and lipid metabolism, it helps to improve the quality of life and survival rate of patients, so how to improve the micro-inflammatory status are a focus for researchers.
Objective: was to observe the effect of high flux hemodialysis (HFHD) with Gambro polyflux 170H dialyser and low flux hemodialysis (LFPD) with polyflux 17L dialyser on high-sensitivity C-reactive protein in patients with maintenance hemodialysis.
Methods: 60 patients with maintenance hemodialysis were randomly divided into HFHD group and LFHD group. Another 20 cases for physical examinations served as normal control group. The maintenance hemodialysis patients were treated with HFHD using 170H dialyser dliahyser and LFHD using 17L dialyser, three times per week, 4 hours once. After 6 months of the treatment, high-sensitive C-reactive protein was determined in patients as well as normal controls before and after treatment.
Results and Conclusion: in two groups, the levels of high-sensitive C-reactive protein before the treatment were higher than normal control (P <0.001). In HFHD group, serum high-sensitive C-reactive protein markedly decreased (P <0.01). In LFHD group, these indices remained unchanged after the dialysis for 6 months. HFHD with 170H polysulfone dialyser is effective in improving micro-inflammation in maintained hemodialysis patients.

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