Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro

Mahdy, El-Sayed M. El-Sayed; El-Mezayen, Hatem A.; Elmowafi, El-Mowafi Abdo; Mohamed, Shaimaa Sabry

doi:10.12816/0037802

Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro

Document Type : Original Article

Authors

¹ Biochemistry Unit, Chemistry Department Faculty of Science, Helwan University,

² Medicinal and Aromatic Plants Unit, Horticulture Research Institute and National Gene Bank, Agricultural Research Center and

³ Medicinal Plant Department, Horticulture Institute Agricultural Research Center

10.12816/0037802

Abstract

Background: in Diabetes, the increase in the oxidative stress and decrease in the antioxidant defense may elevate he susceptibility of diabetic patients to many pathological complications, oxidative induced cell damage has been proposed to play an important role in the etiology of numerous pathological conditions. So, the aim of the present study was to investigate the antioxidant potential of Alcoholic Leaves extract of Balanites aegyptiacea (Heglig) due to the presence of phenolic and flavonoids compounds on uptake of glucose in vitro by erythrocytes of diabetic patients.
Results: in hyperglycemic patients, erythrocytes malondialdehyde level was highly significantly increased (P<0.0001) than that of control. However, the erythrocytes glutathione content was highly significantly decreased (P< 0.0001) when compared to that of corresponding control values. The glucose uptake by erythrocytes of diabetic patients was highly significantly decreased (P < 0.0001) with increasing hyperglycemia (Fasting Blood glucose), while it was highly significantly elevated (P< 0.0001) after addition of Balanites aegyptiacae leaves extract to the incubation medium. On the other hand, the malondialdehyde concentration was highly significantly reduced (P < 0.0001) on adding the extract. So, it could be concluded that , an appreciate support for enhancing Antioxidant supply from natural sources such Balanites aegyptiace leaves extract may help control blood glucose levels and prevent pathological complications of diabetes

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