A Novel Noninvasive Index for Assessment of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis C Virus Infection

Document Type : Original Article

Authors

Internal Medicine Department, Faculty of medicine, Zagazeg University, Egypt

Abstract

Background: Liver fibrosis and cirrhosis are major causes of morbidity and mortality in chronic hepatitis C (CHC) patients.
Objective: To assess a novel non-invasive index in prediction of hepatic fibrosis and cirrhosis in chronic hepatitis c patients by using red cell distribution width to platelet ratio (RPR).
Patients and Methods: This cross-sectional study was conducted on 84 patients with hepatitis C virus in El Ahrar Teaching Hospital during the period from May 2019 to October 2019. The patients were classified into 3 groups, group (I) 26 CHC cases without fibrosis, group (II) 48 CHC cases with fibrosis, and group (III) 10 CHC cases with cirrhosis. The patients were subjected to history taking, clinical examination, laboratory investigations (CBC, liver function, kidney function, INR), and imaging modalities.
Results: There was a higher sensitivity of RPR (83.3%) in detecting fibrotic liver among CHC cases and ability of 73.4% to negative cases among truly negatives, with higher accuracy of 78.6% than other scores which had high sensitivity of 75%, 77.1% and 68.8% and specificity of 69.4%, 72.2% and 72.2% of APRI score, FIB4 and AAR respectively. While, there was a higher sensitivity of RPR (90%) in detecting cirrhotic liver among CHC cases and ability of 97.4% to detect negative cases among truly negatives, with higher accuracy of 96.4% than other scores, which had high sensitivity of 90%, 80% and 80% and specificity of 95.9%, 85.9% and 95.5% of APRI score, FIB4 and AAR respectively.
Conclusion: The progression and prognosis of chronic hepatitis C using a complete blood cell count.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 82, Issue 1
January 2021
Pages 156-163

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