Estimation of Serum Ferritin Level in Preterm Labour

El-Shahawy, Hazem F.; Hendawy, Sherif  F.; Hassanin, Alaa S.; Abd El-Azeem, Mona M.

doi:10.12816/0039690

Estimation of Serum Ferritin Level in Preterm Labour

Document Type : Original Article

Authors

¹ Obstetrics and Gynecologydepartment, Faculty of Medicine,Ain Shams University, Egypt

² Department of Obstetrics and Gynecology Alex. Governorate Obstetric Hospital, (Dar Ismail Hospital), Egypt.

10.12816/0039690

Abstract

Background: Preterm birth is the leading cause of newborn deaths and also the leading cause of death in children under 5 years of age. There is wide spread suspicion that subclinical infection is a common accompaniment and cause of preterm labour. Ferritin is an acute phase reactant and it increases during inflammation.
Aim: The objective of this study is to measure serum ferritin level in cases of established preterm labour (PTL) as a possible marker of infection.
Study Setting: This study conducted at Ain Shams University Maternity Hospital from March 2015 to November 2015.
Study design: A case-control study.
Patients and Methods: The study involved 2 groups.
Study population: 60 cases divided into two groups:

Group (I): included 30 patients with established (PTL) between 30 to 34 weeks gestational age (GA).
Group (II): (Control group) 30 patients with uncomplicated pregnancies between 30 to 34 weeks GA. Serum ferritin was analyzed in the 2 groups.

Results: The results pointed out that there was statistically significant difference between two groups as regarding serum ferritin level as p value was <0.0001 . The median serum ferritin level in preterm labour group and control group was 150 (100 – 150) ng/ml and 20 (15 – 25) ng/ml respectively. The best cut off value of serum ferritin as predictor of preterm labour was >55 ng/ml with a sensitivity of 96.7% and specificity of 96.7 %.
Conclusion: Serum ferittin can be used as a marker of preterm labour.

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