PCR Genetic Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Women with Endometriosis

Abbas, Ahmed Mohamed; EL-Desouky, Sayeda Ibrahim; Allam, Ihab Fouad Serag Eldin; Mohamed, Deena A; Abou –Gamrah, Amgad Alsaid

doi:10.21608/ejhm.2020.132889

PCR Genetic Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Women with Endometriosis

Document Type : Original Article

Authors

10.21608/ejhm.2020.132889

Abstract

Background: In endometriosis, there is a chronic immune and inflammatory reaction.
Objective: To study the PCR genetic expression of interleukin 37 in the eutopic and ectopic endometrium of women with endometriosis in comparison with controls.
Patient and Methods: Forty-six patients were included in the study. Twenty-three women diagnosed as endometriosis and twenty-three women diagnosed as free of endometriosis were subjected to laparoscopy for any other gynecological cause. Interleukin 37 gene expression was studied in ectopic and eutopic endometrium using polymerase chain reaction.
Results: Ectopic endometrium expressed high levels of mRNA compared to eutopic endometrium in endometriosis patients. Eutopic endometrium of endometriosis patients expressed high levels of mRNA compared to eutopic endometrium of controls.
Conclusion: The finding of high mRNA produced in endometrial tissue suggests that interleukin 37 may be important in the chronic inflammation occurring during endometriosis.

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