Ali, F., Abdel Rehim, A., El Sayed, H., Fouad, S., Elmahdi, A. (2020). Study of CD4 and CD8 Subsets in Morbid Obese Population. The Egyptian Journal of Hospital Medicine, 81(7), 2310-2317. doi: 10.21608/ejhm.2020.131249
Fawzia Hassan Abo Ali; Asmaa Saber Mostafa Abdel Rehim; Hoda Mohamed El Sayed; Shaimaa Hani Fouad; Amira Ramadan Elmahdi. "Study of CD4 and CD8 Subsets in Morbid Obese Population". The Egyptian Journal of Hospital Medicine, 81, 7, 2020, 2310-2317. doi: 10.21608/ejhm.2020.131249
Ali, F., Abdel Rehim, A., El Sayed, H., Fouad, S., Elmahdi, A. (2020). 'Study of CD4 and CD8 Subsets in Morbid Obese Population', The Egyptian Journal of Hospital Medicine, 81(7), pp. 2310-2317. doi: 10.21608/ejhm.2020.131249
Ali, F., Abdel Rehim, A., El Sayed, H., Fouad, S., Elmahdi, A. Study of CD4 and CD8 Subsets in Morbid Obese Population. The Egyptian Journal of Hospital Medicine, 2020; 81(7): 2310-2317. doi: 10.21608/ejhm.2020.131249
Study of CD4 and CD8 Subsets in Morbid Obese Population
Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Immune dysfunction is one of the co-morbidities that became well recognized several years ago in people with obesity. Objective. To study the peripheral blood T-cell compartment, the absolute counts and relative frequencies of T-cell subpopulations including CD8+T cells; CD4+Tcells in adults suffering morbid obesity compared to lean subjects. Patients and methods: This case-control study included 30 adults with morbid obesity and 20 lean healthy subjects who were age and sex-matched.CD4 and CD8 absolute and relative count together with CD4/CD8 ratio were assessed and compared between the two groups. Results: Adults with morbid obesity had higher total leucocyte count (TLC), CD4 percentage, CD4 absolute count, and CD4/CD8 ratio than that of controls. On the other hand, the CD8 percentage was lower in people with morbid obesity. There were positive correlations between CD4% and BMI, waist circumference, cholesterol, triglyceride, LDL, and TLC and neutrophils count. There was a negative correlation between the percentage of CD8 and BMI. CD4/CD8 ratio correlated positively with BMI but negatively with systolic blood pressure. Conclusion: CD4+ CD8+ T lymphocytes assay could help assess the immune state and recognize obese at risk of immune dysfunction complication as infection and metabolic diseases.
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