Risk Factors of Type 1 Diabetes Mellitus in Children Attending Aswan University Hospital

Document Type : Original Article

Authors

Department of Pediatrics, Faculty of Medicine, Aswan University

Abstract

Background: Type 1 diabetes (T1DM) is a chronic disease caused by immune-mediated destruction of insulin producing beta cells in the pancreas. The destruction of beta cells results in insulin insufficiency, and patients develop life-threatening hyperglycemia that clinically manifests with weight loss, polyuria, and polydipsia. Objective: This study aimed to search for disease prediction and disease prevention.
Patients and methods: The present cross-sectional study was conducted at Aswan University Hospital. One hundred children with T1DM were included during the period from April to November 2018. The mean age of the included patients was 7.2 ± 4.3 years and the age at onset of the disease was 4.56 ± 2.9 years. 56% of the patients were males.
Results: In our cohort, we found that, in terms of obstetric history, 76% of the mothers delivered by CS and 12% of them had history of preeclampsia. 13% had a history of gestational diabetes. On the other hand, 13% and 29% of the mothers had a history of infectious diseases and use of antibiotics, respectively. There were no statistically significant associations between age group and preeclampsia (p =0.33), gestational diabetes and use of insulin (p =0.67), infectious diseases (p =0.91), use of antibiotic (p =0.26), use of antihypertensives (p =0.22), and mode of delivery (p =0.067).
Conclusion: In conclusion, Egyptian children with T1DM had wide range of genetics, environmental, maternal, and neonatal risk factors that may have contributed to the development of T1DM.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 81, Issue 6
October 2020
Pages 2265-2273

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