Assessment of Body Composition in Patients with Multiple Sclerosis: Institutional-Based Cross-Sectional Study

Document Type : Original Article

Authors

1 Department of Internal Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt

2 Department of Neurology, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Abstract

Background: Multiple sclerosis (MS) is the most common progressive neurologic disease all over the world. MS is an immune-mediated disease and there is contradictory data regarding cardiovascular morbidity and mortality risk factors in MS patients.
Objective: To assess the body composition in MS patients, and to explore the associations of anthropometric indices and metabolic risk factors with the phenotypic features of MS.
Patients and Methods: a cross-sectional study included 150 patients fulfilling the diagnostic criteria for MS according to the revised McDonald’s criteria 2010, and 145 age and sex-matched healthy controls. Fat mass index (FMI) and free fat mass index (FFMI) were assessed by dual-energy X-Ray absorptiometry (DEXA).
Results: This study was conducted on MS patients with phenotypes; RRMS (82%) and SPMS (18%). our results revealed that the distribution of body composition among MS patients was 30 %, overweight was 48% and lean was 22%. Also, MS patients had significantly higher values of systolic and diastolic blood pressure as well as dyslipidemia, obesity indices, and hs-CRP compared to the control group, P-value < 0.001. Interestingly, there were significantly higher values of the expanded disability status scale (EDSS), dyslipidemia, obesity indices, and hypertension in the obese group compared to other groups.
Conclusions: MS patients had higher values of dyslipidemia and obesity indices than control groups. Among MS, the prevalence of overweight patients was higher than lean and obese MS patients.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 81, Issue 6
October 2020
Pages 2139-2145

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