Study of The Podocalyxin as An Early Marker for Diabetic Nephropathy and Its Correlation with Stages of Diabetic Nephropathy in A Sample of Egyptian Patients with T2DM
Background: Nephropathy is a major complication of diabetes, and is the main cause of end-stage kidney disease. Early recognition of nephropathy in diabetic patients is critical because it creates an opportunity to prevent the occurrence of diabetic nephropathy and/or even slow down the process of end-stage kidney disease attributable to diabetes. Human cells; podocytes (pods) have been shown to be functionally and structurally affected in the natural history of diabetic nephropathy. Objective: Study of the podocalyxin as an early marker for diabetic nephropathy and its correlation with stages of diabetic nephropathy in a sample of Egyptian patients with type 2 diabetes mellitus (T2DM). Patients and Methods:This study was a cross sectional study conducted on 80 subjects divided into four groups: Group 1: 20 diabetic patients with normalbuminuria. Group 2: 20 diabetic patients with nephropathy and microalbuminuria stages. Group 3: 20 diabetic patients with nephropathy and macroalbuminuria stages, Group 4:20 apparently healthy volunteers were included as a control group. Results: Urinary podocalyxin (PCX) was significantly higher in patients group compared to control group. Urinary PCX was significantly higher in macroalbuminuric group followed by microalbuminuric group then normoalbuminuric group. There was a positive significant correlation between urinary PCX and glycemic profile [Fasting blood sugar (FBS), 2hrPP, Glycosylated Hemoglobin (HbA1C)], serum creatinine and albumin creatinine ratio (ACR). Conclusion: Urinary podocalyxin is a beneficial as an early marker for early stages of diabetic nephropathy in type 2 DM patients.
Shelbaya, S. E. A., Ibrahim, R. H., Sawirs, N. S., & Ali, H. M. (2020). Study of The Podocalyxin as An Early Marker for Diabetic Nephropathy and Its Correlation with Stages of Diabetic Nephropathy in A Sample of Egyptian Patients with T2DM. The Egyptian Journal of Hospital Medicine, 81(5), 2099-2102. doi: 10.21608/ejhm.2020.127000
MLA
Salah El-Din Ahmed Shelbaya; Rana Hashem Ibrahim; Nourhan Safwat Sawirs; Hanan Mahmoud Ali. "Study of The Podocalyxin as An Early Marker for Diabetic Nephropathy and Its Correlation with Stages of Diabetic Nephropathy in A Sample of Egyptian Patients with T2DM", The Egyptian Journal of Hospital Medicine, 81, 5, 2020, 2099-2102. doi: 10.21608/ejhm.2020.127000
HARVARD
Shelbaya, S. E. A., Ibrahim, R. H., Sawirs, N. S., Ali, H. M. (2020). 'Study of The Podocalyxin as An Early Marker for Diabetic Nephropathy and Its Correlation with Stages of Diabetic Nephropathy in A Sample of Egyptian Patients with T2DM', The Egyptian Journal of Hospital Medicine, 81(5), pp. 2099-2102. doi: 10.21608/ejhm.2020.127000
VANCOUVER
Shelbaya, S. E. A., Ibrahim, R. H., Sawirs, N. S., Ali, H. M. Study of The Podocalyxin as An Early Marker for Diabetic Nephropathy and Its Correlation with Stages of Diabetic Nephropathy in A Sample of Egyptian Patients with T2DM. The Egyptian Journal of Hospital Medicine, 2020; 81(5): 2099-2102. doi: 10.21608/ejhm.2020.127000
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