Study of The Effect of Nutrition and Glycemic Control and on IGF-1 and Growth in Pre-pubertal Egyptian Children with T1DM

Botros, Raef Malak; El-Sherbeeny, Aliaa Ahmed Abdo; El Barbary, Nancy Samir; Muhammed, Ala Muhammed; Ali, Hanan Mahmoud

doi:10.21608/ejhm.2020.126407

Study of The Effect of Nutrition and Glycemic Control and on IGF-1 and Growth in Pre-pubertal Egyptian Children with T1DM

Document Type : Original Article

Authors

10.21608/ejhm.2020.126407

Abstract

Background: Pre-Pubertal children who have T1DM are shorter than their non-diabetic peers. Objective: In the current study we aimed to evaluate the role of HbA1c and IGF-1 in these cases. Patients and Methods: The present study was a cross-sectional study conducted on 80 pre-pubertal Egyptian children: 30 males, 30 females with T1DM and 20 age-matched controls (10 males and 10 females), the participants were recruited from the Outpatient Clinic of the Pediatric Department of Ain Shams University Hospitals and the National Institute of Diabetes and Endocrinology in Cairo, Egypt during the period from July 2018 to January 2019. Results: The height and weight percentiles were found to be lower in type 1 diabetic children when compared to the controls with median values of 14.50 (IQR 27.98) in male patients, 17.95 (IQR 29.18) in female patients, and 87 (IQR 20.58) in the controls. A negative correlation between serum IGF-1 and HbA1c as well as the height and weight percentiles were found with (P = 0.014, 0.009, and 0.05 respectively). Serum IGF-1 levels were also found to be significantly lower in patients (P <0.001) with a mean value of (77.60 ± 69.377) in male patients and (64.0 ± 29.402) in female patients and (201.0 ± 102.798) in the controls. HbA1c was also found to be negatively correlated with height percentile (P = 0.012). Conclusion: The glycemic control tested by HbA1c is an important indicator of linear growth in pre-pubertal children, Height, and weight percentiles were found to be lower in type 1 diabetic patients when compared to the healthy controls (P < 0.001) in both cases.

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