Anter, M., Shabana, A., Badr, S., Hoseny, N. (2020). Changes in Fetal and Uteroplacental Doppler Waveforms After Antenatal Dexamethasone Administration in Women at Risk of Spontaneous Preterm Birth. The Egyptian Journal of Hospital Medicine, 81(5), 2046-2053. doi: 10.21608/ejhm.2020.124872
Mohamed Elsibai Anter; Ayman Abd Elkader Shabana; Sally Mohamed Ali Badr; Nehad Mahmoud Hoseny. "Changes in Fetal and Uteroplacental Doppler Waveforms After Antenatal Dexamethasone Administration in Women at Risk of Spontaneous Preterm Birth". The Egyptian Journal of Hospital Medicine, 81, 5, 2020, 2046-2053. doi: 10.21608/ejhm.2020.124872
Anter, M., Shabana, A., Badr, S., Hoseny, N. (2020). 'Changes in Fetal and Uteroplacental Doppler Waveforms After Antenatal Dexamethasone Administration in Women at Risk of Spontaneous Preterm Birth', The Egyptian Journal of Hospital Medicine, 81(5), pp. 2046-2053. doi: 10.21608/ejhm.2020.124872
Anter, M., Shabana, A., Badr, S., Hoseny, N. Changes in Fetal and Uteroplacental Doppler Waveforms After Antenatal Dexamethasone Administration in Women at Risk of Spontaneous Preterm Birth. The Egyptian Journal of Hospital Medicine, 2020; 81(5): 2046-2053. doi: 10.21608/ejhm.2020.124872
Changes in Fetal and Uteroplacental Doppler Waveforms After Antenatal Dexamethasone Administration in Women at Risk of Spontaneous Preterm Birth
1Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2Obstetrics and gynecology department, El-Bagour general Hospital, Menoufia, Egypt
Abstract
Background: Early detection of fetal risk is one of the main issues in today's obstetrics. Ultrasound diagnosis plays a significant role, as the introduction of the Doppler imaging method in the evaluation of blood flow has enabled non- invasive assessment of uteroplacental circulation. Objective: To assess the impact of maternal dexamethasone on doppler waveforms velocity flow of the fetal umbilical and middle cerebral arteries and maternal uterine arteries in pregnant women at risk of preterm labor with normal fetal vascular resistance. Patients and methods: This cross-sectional study was conducted at the Department of Obstetrics and Gynecology at Menoufia University hospital on 36 patients who were diagnosed as having threatened preterm birth. All the patients were enrolled in the study with routine follow up according to local protocols in the period between January 2019 and November 2019. Full history taking, full general, obstetric examination, and Ultrasound examination was performed.
Results: After dexamethasone administration, Umbilical A resistive and Pulsatility indexes were significantly decreased to (1.084 ± 0.118 and 0.66 ± 0.054) in comparison to before dexamethasone (1.121±0.124 and 0.70±0.058). Regarding the Uterine Doppler values, mean Pulsatility index before dexamethasone was 0.79±0.049 (right) and 0.78 ±0.038 (left) decreased significantly to 0.78±0.044 (right) and 0.77±0.036 (left) after dexamethasone. Similarly, the mean Resistive index before dexamethasone was 0.55±0.027 (right) and 0.54±0.026 (left) decreased significantly to 0.53±0.023 (for right and left) after dexamethasone.
Conclusions: dexamethasone administration for the pregnant mothers at risk of preterm labor enhance the flow of blood to the fetal umbilical, middle cerebral arteries and maternal uterine arteries 24 hrs. after its administration.
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