Background: Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes. Low vitamin D levels and decreased femoral cartilage thickness (FCT) have been observed in SSc. Objectives: This study aimed to evaluate the relation between serum level of vitamin D and FCT among SSc patients and to correlate both with clinical features and disease severity score. Patients and Methods: This study included 40 SSc patients, divided into 2 groups; group 1: sufficient vitamin D (level > 30 ng/ml), group 2: insufficient vitamin D (level < 30 ng/ml). All patients were subjected to history taking, clinical examination, and assessment of disease severity by Medsger Disease Severity Index (MDSI), laboratory investigations, 25 (OH) vitamin D level and musculoskeletal ultrasound of both knees to assess FCT. Three midpoint measurements of FCT were taken from each knee: lateral femoral condyle (LFC), femoral intercondylar area (ICA) and medial femoral condyle (MFC). Results: Thin FCT was found in 60% of patients. There was insufficient vitamin D level in 65% of patients. Age was negatively correlated with FCT at right MFC area and female parity was also negatively correlated with right ICA and MFC areas. FCT was significantly lower in group 1 at areas of left MFC and LFC areas, but no relation between femoral cartilage thickness and vitamin D level with disease severity. Conclusion: There is significant relation between femoral cartilage thickness and vitamin D level in scleroderma patients, both decline in SSc patients but not related to disease severity score.
Teama, M. A. E. M., Farouk, H. M., Hussein, S. A., & Badr, F. M. (2020). Femoral Cartilage Thickness and Vitamin D Level in Systemic Sclerosis Patients and Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 81(5), 1977-1984. doi: 10.21608/ejhm.2020.123483
MLA
Mohammed Abd El Monem Teama; Hanan Mohamed Farouk; Safaa A. Hussein; Fatma Mohammed Badr. "Femoral Cartilage Thickness and Vitamin D Level in Systemic Sclerosis Patients and Relation to Disease Severity", The Egyptian Journal of Hospital Medicine, 81, 5, 2020, 1977-1984. doi: 10.21608/ejhm.2020.123483
HARVARD
Teama, M. A. E. M., Farouk, H. M., Hussein, S. A., Badr, F. M. (2020). 'Femoral Cartilage Thickness and Vitamin D Level in Systemic Sclerosis Patients and Relation to Disease Severity', The Egyptian Journal of Hospital Medicine, 81(5), pp. 1977-1984. doi: 10.21608/ejhm.2020.123483
VANCOUVER
Teama, M. A. E. M., Farouk, H. M., Hussein, S. A., Badr, F. M. Femoral Cartilage Thickness and Vitamin D Level in Systemic Sclerosis Patients and Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 2020; 81(5): 1977-1984. doi: 10.21608/ejhm.2020.123483
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