El-Bakry, M., Ibrahim, R., Mohaseb, E. (2020). Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats. The Egyptian Journal of Hospital Medicine, 81(5), 1958-1966. doi: 10.21608/ejhm.2020.123477
Mohammed Hassan El-Bakry; Ramadan Hassan Ibrahim; El-Shazly Abdelaal Mohaseb. "Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats". The Egyptian Journal of Hospital Medicine, 81, 5, 2020, 1958-1966. doi: 10.21608/ejhm.2020.123477
El-Bakry, M., Ibrahim, R., Mohaseb, E. (2020). 'Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats', The Egyptian Journal of Hospital Medicine, 81(5), pp. 1958-1966. doi: 10.21608/ejhm.2020.123477
El-Bakry, M., Ibrahim, R., Mohaseb, E. Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats. The Egyptian Journal of Hospital Medicine, 2020; 81(5): 1958-1966. doi: 10.21608/ejhm.2020.123477
Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats
Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
Abstract
Background: Hypercholesterolemia is one of the most important risk factors for atherosclerosis and subsequent cardiovascular disease (CVD). CVD is the leading cause of cardiovascular morbidity and mortality worldwide, currently, there is a major trend to use herbal remedies for the treatment and prevention of hypercholesterolemia. Objective: In the present work, we investigated the effect of aqueous green tea extract on lipid profile and vascular reactivity & changes in body weight in hypercholesterolemic albino rats Materials and methods: Adult male albino rats were chosen as an animal model for this study. Rats were brought from animal house, Faculty of Medicine, Assiut University, Assiut, Egypt, and were maintained on a balanced diet with water supply freely in clean containers. They were kept for two weeks to adapt to the laboratory conditions before the start of the experiment. Forty age-matched male albino rats with initial body weights ranging from 200 to 220g were used. Results: In group (III & IV), total cholesterol, LDL, and triglyceride levels were significantly decreased respectively& HDL were significantly increased compared with the group II (p < 0.05). also in group (III & IV) the aortic contractility is decreased and aortic relaxation were significantly increased compared with the group II (p < 0.05) & body weight was decreased significantly (p < 0.05) in group IV compared with the group II. Conclusion: The results obtained by the present study showed that administration of aqueous green tea extract to the hypercholsterolemic rats has a role in improvement of plasma lipids, vascular reactivity& body weight.