Hamed, A., Abdelmeguid, M., Ismail, A., Othman, A. (2020). Evaluation of Vitamin D in Preterm Neonates and Effects of its Supplementation in Preterm Neonates with Respiratory Distress Syndrome. The Egyptian Journal of Hospital Medicine, 81(4), 1742-1749. doi: 10.21608/ejhm.2020.120004
Amira Mohammed Mohammed Hamed; Mona Mohamed Abdelmeguid; Ahmed Haggag Ismail; Aya Eissa Ahmed Othman. "Evaluation of Vitamin D in Preterm Neonates and Effects of its Supplementation in Preterm Neonates with Respiratory Distress Syndrome". The Egyptian Journal of Hospital Medicine, 81, 4, 2020, 1742-1749. doi: 10.21608/ejhm.2020.120004
Hamed, A., Abdelmeguid, M., Ismail, A., Othman, A. (2020). 'Evaluation of Vitamin D in Preterm Neonates and Effects of its Supplementation in Preterm Neonates with Respiratory Distress Syndrome', The Egyptian Journal of Hospital Medicine, 81(4), pp. 1742-1749. doi: 10.21608/ejhm.2020.120004
Hamed, A., Abdelmeguid, M., Ismail, A., Othman, A. Evaluation of Vitamin D in Preterm Neonates and Effects of its Supplementation in Preterm Neonates with Respiratory Distress Syndrome. The Egyptian Journal of Hospital Medicine, 2020; 81(4): 1742-1749. doi: 10.21608/ejhm.2020.120004
Evaluation of Vitamin D in Preterm Neonates and Effects of its Supplementation in Preterm Neonates with Respiratory Distress Syndrome
Background: Prematurity and related problems, especially respiratory distress syndrome, are one of the main challenges for neonatal medicine. Many studies have shown the relationship between lung development and vitamin D. Objective: To investigate Vitamin D status and to evaluate the effect of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants. Patients and Methods: This study included 90 preterm neonates chosen from those at NICU of Minya General Hospital and Al-Azhar University, Assiut, Egypt. The cases were divided into two main groups; a group with RDS (case group 66 cases) and a group without RDS (control group =24 cases). The group with RDS was further subdivided into three subgroups (subgroup I received just traditional therapy and the subgroup II received traditional therapy plus vitamin D 400 IU/day, while subgroup III received traditional therapy plus vitamin D 800 IU/day). Results: The RDS group had lower neonatal and maternal vitamin D concentrations than the group without RDS. We found a strong positive correlation between neonatal and maternal vitamin D levels on the day of delivery. The subgroups supplemented with vitamin D had a significant improvement in all ABG parameters, lower Downs score, less hospital stay, less morbidity than the subgroup without vitamin D supplementation. Conclusion: Administration of vitamin D as adjuvant therapy in cases of RDS was associated with a significant decrease in severity, rate of complications, and duration of hospital stay in the subgroup received 800 IU/Day compared to the subgroup received 400 IU/Day.
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