TSH and AMH in Infertile Women

Sammour, Hazem Mohamed; Abuelghar, Wessam Magdi; El-Salam, Nermine Essam El-Din Abd; Ahmed, Haitham Hassan

doi:10.12816/0040607

TSH and AMH in Infertile Women

Document Type : Original Article

Authors

Obstetrics and Gynecology Department, Faculty of Medicine, Ain Shams University

10.12816/0040607

Abstract

Introduction: Infertility is defined as the inability of a couple to achieve pregnancy over an average period of one year (in women under 35 years of age) or 6 months (in women above 35 years of age) of unprotected sexual intercourse. Infertility can be due to female, male reasons or both. It can be either primary or secondary. Aim of the work: The aim of this study is to evaluate the association between thyroid function and serum AMH levels. Methodology: Type of the study: this study was conducted a case control study. Study site: This study was carried out at Ain-Shams maternity hospital (outpatient infertility clinic). Duration of study: In the period between December 2015 and December 2016. Patients and study design: According to the sample size calculation by using the IBM© Sample Power© Software (IBM© Corp., Armonk, NY, USA), the study performed on 128 women divided into 2 equal groups as follows:
Group “1” (study group): 64 infertile women at reproductive age (20-35) years.
Group “2” (Control group): 64 normal fertile women aged (20– 35) years.
Result: TSH and patient age that were strongly correlated with AMH levels in 26 post-matched infertile patients using multivariate logistic regression. Both TSH levels and patient age significantly impacted AMH levels in infertile patients. Conclusion: AMH levels were inversely correlated with TSH levels in infertile women of reproductive age. Recommendations: The study should be done using larger sample sizes in a multicenter trial including both urban and rural areas to validate results. Autoimmune thyroid antibodies (thyroglobulin antibody and thyroid peroxidase antibody) could be assessed with TSH, FT4, FT3 and AMH as there is a strong association between infertility and autoimmune thyroid antibodies.

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