Gameil, M., Elsebaie, A., Marzouk, R., Elmenebawy, N. (2020). Influence of Overweight and Obesity on Bone Mineral Density in Egyptian Premenopausal Women. The Egyptian Journal of Hospital Medicine, 81(3), 1654-1658. doi: 10.21608/ejhm.2020.117023
Mohammed Ali Gameil; Ahmed Hassan Elsebaie; Rehab Elsayed Marzouk; Nesma Alaa Elmenebawy. "Influence of Overweight and Obesity on Bone Mineral Density in Egyptian Premenopausal Women". The Egyptian Journal of Hospital Medicine, 81, 3, 2020, 1654-1658. doi: 10.21608/ejhm.2020.117023
Gameil, M., Elsebaie, A., Marzouk, R., Elmenebawy, N. (2020). 'Influence of Overweight and Obesity on Bone Mineral Density in Egyptian Premenopausal Women', The Egyptian Journal of Hospital Medicine, 81(3), pp. 1654-1658. doi: 10.21608/ejhm.2020.117023
Gameil, M., Elsebaie, A., Marzouk, R., Elmenebawy, N. Influence of Overweight and Obesity on Bone Mineral Density in Egyptian Premenopausal Women. The Egyptian Journal of Hospital Medicine, 2020; 81(3): 1654-1658. doi: 10.21608/ejhm.2020.117023
Influence of Overweight and Obesity on Bone Mineral Density in Egyptian Premenopausal Women
Internal medicine department, Faculty of medicine, Mansoura University, Mansoura, Dakahlia, Egypt.
Abstract
Background and objective: Can overweight and obesity exert a detrimental or a protective effect on bone density in premenopausal women? We studied the correlation between obesity and bone mineral density (BMD) in premenopausal women in Egypt. Patients and methods: a Case-control study included 50 overweight and obese premenopausal women compared to 50 normal weight women of matched age. Clinical history, examination, laboratory tests and DEXA scan were done. Results: T–score and Z-score at the forearm, hip, and lumbar vertebrae were significantly lower in the case group than the control group. In all participants, we found a significant negative correlation between body mass index (BMI) with Z-score ( forearm), BMI and bodyweight with Z-score (hip) and BMI, waist circumference (WC) and bodyweight with Z-score (lumbar vertebrae). We found a significant negative correlation between waist/ hip ratio (WHR) and T-score (hip) and between BMI, waist/hip ratio and bodyweight with T-score (lumbar vertebrae). In the overweight and obese participants, BMI was inversely correlated with Z-score (forearm, hip, and lumbar vertebrae) as well as waist circumference with Z-score (lumbar vertebrae). With post-hoc analysis, T-score at the lumbar vertebrae was significantly lower in the obese group. With adjustment of the age, (age and WC) and (age and WHR), we found a significant negative association in the obese group versus the lean group with Z-score (forearm, hip and lumbar vertebrae). Conclusion: Overweight and obese Egyptian premenopausal women were more vulnerable to lower bone density.