Primary Immuno-Deficiencies in Pediatrics

Aljehani, Nouf Abdullah; Sallum, Thamer Fahad; Halawani, Abdulghaffar Talal; Alqahtani, Alwah  Mohammed; Alahmadi, Khaled Dakhel; Awadh, Hassan Mohammed AL; Alkhawajah, Abdullah Mohammed; Alhajji, Ahmed Abdulhadi; Malwi, Faisal Abdullah; Aldhalan, SulaimanMohammed; Alsahafi, Sara Falah; Aljahdli, Salmah Mojeer; Alwafi, Mayada  Salem; Alamer, Hassan Habeeb; Sultan, Anmar Ahmed; Al-Shehab, Maria Mohammed

doi:10.12816/0043822

Primary Immuno-Deficiencies in Pediatrics

Document Type : Original Article

Authors

¹ King Abdulaziz University

² Majmaah University

³ Umm Al-Qura University

⁴ King Faisal University

⁵ Maternity and Children Hospital –Alhasa, King Khalid University

⁶ King Saud University

⁷ Battarjee Medical Collage

⁸ King Salman bin abdulaziz hospital

⁹ Primary Health care

10.12816/0043822

Abstract

Introduction: There are many different types of primary immunodeficiency syndromes, with an overall prevalence of one in every 2,000 children in the United States. These syndromes are broadly classified as B-cell, T-cell, phagocytic, complement, or combined immunodeficiency disorders, mainly affecting children from a very young age.
Methodology: Weconducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE from January 1987 to March 2017. The following search terms were used: immunodeficiency syndromes, B-cell disorder, T-cell disorder, complement disorder, phagocytic diseases, diagnosis of primary immunodeficiency, newborn screening
Aim of the work: In this study we aimed to understand the various common types of primary immunodeficiency syndromes, and also study their diagnosis and screening methods.
Conclusion:Early diagnosis with the help of newborn screening and data recording can help in reducing significant mortality and morbidity of children born with such disorders. Primary health care providers and pediatricians must keep a high degree of suspicion as many times the presentation can be subtle.

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