Assessment of Follicular-Fluid Neurotrophin Levels as Predictor for Ovarian Reserve in Women Undergoing Assisted Reproductive Technology for Different Etiologies of Infertility

Document Type : Original Article

Authors

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University

Abstract

Background: brain-derived neurotrophic factor (BDNF) is a27-kDa polypeptide that belongs to the neurotrophin family binding with high-affinity protein kinase receptors (Trk) and the unselective p75NGFR receptor. The BDNF gene has a complex structure with multiple regulatory elements and four promoters that are differentially expressed in the central or peripheral tissue. Aim of the Work: this study aimed to detect affection of follicular fluid neurotrophin level in different types of infirtility and its using as peredictor for ovarian reserve.
Patients and Methods: this crosssectional study was carried out in Ain Shams University, Maternity Hospitals Assisted Reproductive Technology Unit (ART unit) in the period from Septemper2016 to June 2017.
Results: the present study showed a cut-off value of BDNF for the patients who underwent this study was 2.7 pg/ml with sensitivity of 74.2%, specificity 95.5%, PPV 85.2% and NPV 91.4%. Conclusion: FF-BDNF measurement on the d-OPU in women with different types of infertility underwent COH for IVF-ET, had positive correlation with ovarian reserve and positive predictor of pregnancy which occurred in 25.8% of cases. Recommendations: BDNF has positive correlation with ovarian reserve and positive correlation with pregnancy outcome so we recommend to measure serum BDNF before starting IVF cycle as predictive factore and cost effective.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 70, Issue 4
January 2018
Pages 584-593

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