Evaluation of Stress Ulcer Prophylaxis Benefits and Outcomes: A Simple Literature Review

Alghamdi, Mohammed Yaan Allah M; Alluhaybi, Abdulelah Hassan; Alzahid, Abdullah Abdulaziz; Akkur, Murad Abdullah; Alshenaiber, Mohammed Abdulaziz A; Shati, Riyadh Othman Abdullah; Alnajjar, Wed Ziyad; Anbarserri, Sanaa Mahmoud; Alqahtani, Reem Awad; Alzahrani, Lamees Hassan

doi:10.21608/ejhm.2018.11356

Evaluation of Stress Ulcer Prophylaxis Benefits and Outcomes: A Simple Literature Review

Document Type : Original Article

Authors

¹ Al-Baha University

² Umm Al-Qura University

³ Imam Abdulrahman Bin Faisal University

⁴ Jazan University

⁵ Misr University for Science and Technology

⁶ King Abdulaziz University

⁷ Taibah University

⁸ King Khalid University

⁹ Ibn Sina National College

10.21608/ejhm.2018.11356

Abstract

Background: One of the commonest complications in critically ill patients is stress related mucosal disease (SRMD). It can be associated with increase in the risk of development of overt gastrointestinal bleeding. As a result, a lot of literatures have been done to evaluate the pathogenesis that stands behind its development, and assessment of the measures that can be used to lower the risk of its 'occurrence.
Aim of the Work: In this review we aimed at discussing the pathogenesis that stands behind stress ulcer development, Also, discussing the role of anta- acid as a prophylaxis against harms and benefits. In addition to providing an intensive study that analyzed the recent literatures considered this field of study.
Methodology: A comprehensive search was done using biomedical databases; Medline, and Pubmed, for studies concerned with assessment of stress ulcer prophylaxis. Keywords used in our search through the databases were as; “stress ulcer”, “stress ulcer prophylaxis”, “stress ulcer in ICU patients”.
Conclusion: Stress related mucosal disease is associated with increase in the risk of clinically overt gastrointestinal bleeding. As a result, patients who require mechanically ventilation for more than 48 h and those with a manifest of coagulopathy are highly recommended for having stress ulcer prophylaxis (SUP). Anta- acid such as Proton Pump Inhibitors (PPIs) and histamine 2 receptor antagonists (H2RA) help in prevention of gastrointestinal bleeding, but did not have any effect on mortality risk reduction. Still further prospective randomizes trials needs to be done to evaluate our scientific research survey to guide the physicians in making a decision about the use of SUP in ICU patients.

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