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The Egyptian Journal of Hospital Medicine
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H. Alzain, W., Altowairqi, M., Alalawi, D., Althubaiti, N., Abduljawad, S., Alloqmani, S., Alshawaf, A., Alqahtani, A., M Albridi, A., Motahar, A., Alreshoudi, ,., Mahdi, L. (2018). The Correlation between Vitamin D and Cognition: A Review. The Egyptian Journal of Hospital Medicine, 70(6), 1047-1055. doi: 10.12816/0044361
Wesal Ibrahim H. Alzain; Meshal Mohammed Altowairqi; Duaa Khalid M Alalawi; Norah Mohammed A Althubaiti; Siyadah Anwar Abduljawad Abduljawad; Sami Muslim Alloqmani; Amani Hussain Alshawaf; Abdullah Saleh Alqahtani; Ahmad Ibrahim M Albridi; Abdullah Jameel Motahar; , Mohamad Fahad M Alreshoudi; Laila Mossa Mahdi. "The Correlation between Vitamin D and Cognition: A Review". The Egyptian Journal of Hospital Medicine, 70, 6, 2018, 1047-1055. doi: 10.12816/0044361
H. Alzain, W., Altowairqi, M., Alalawi, D., Althubaiti, N., Abduljawad, S., Alloqmani, S., Alshawaf, A., Alqahtani, A., M Albridi, A., Motahar, A., Alreshoudi, ,., Mahdi, L. (2018). 'The Correlation between Vitamin D and Cognition: A Review', The Egyptian Journal of Hospital Medicine, 70(6), pp. 1047-1055. doi: 10.12816/0044361
H. Alzain, W., Altowairqi, M., Alalawi, D., Althubaiti, N., Abduljawad, S., Alloqmani, S., Alshawaf, A., Alqahtani, A., M Albridi, A., Motahar, A., Alreshoudi, ,., Mahdi, L. The Correlation between Vitamin D and Cognition: A Review. The Egyptian Journal of Hospital Medicine, 2018; 70(6): 1047-1055. doi: 10.12816/0044361

The Correlation between Vitamin D and Cognition: A Review

Article 27, Volume 70, Issue 6, January 2018, Page 1047-1055  XML PDF (415.76 K)
Document Type: Original Article
DOI: 10.12816/0044361
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Authors
Wesal Ibrahim H. Alzain1; Meshal Mohammed Altowairqi2; Duaa Khalid M Alalawi3; Norah Mohammed A Althubaiti4; Siyadah Anwar Abduljawad Abduljawad5; Sami Muslim Alloqmani6; Amani Hussain Alshawaf7; Abdullah Saleh Alqahtani8; Ahmad Ibrahim M Albridi9; Abdullah Jameel Motahar8; , Mohamad Fahad M Alreshoudi10; Laila Mossa Mahdi11
11- Jarwal Phcc Makkah Almukaramah
2Prince Sultan Medical Military City
3Warsaw Medical University
4King Abdulaziz University
5Ibn Sina College
6PHC at Madinah
7PHC at Al-Ahsa
8Umm Alqura’a University
9King Khalid University
10Qassim University
11Aseer Central Hospital
Abstract
therapeutic tool in a number of neurological pathologies. More recently, experimental and pre-clinical data suggest a link between vitamin D status and cognitive function. Human studies strongly support a correlation between low levels of circulating 25-hydroxyvitamin D (25(OH)D) and cognitive impairment or dementia in aging populations transcription regulators - has emerged as a serious candidate in nervous system development and function and a. In parallel, animal studies show that supplementation with vitamin D is protective against biological processes Background: During the last 25 years, vitamin D -being a member of the superfamily of nuclear steroid associated with Alzheimer’s disease (AD) and enhances learning and memory performance in various animal models of aging and AD. More recently epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer's disease
Aim of the Study: was to review the recent literature to investigate the correlation between vitamin D status
 and neurocognitive function.
Methods: We searched the medical literature to retrieve studies for the review to 30 November 2017. electronic search in the scientific database from 1965 to 2017– (Medline, Embase, AMED, Psych INFO, the Cochrane Library websites were searched for English Publications were obtained from both reprint requests and by searching the database. Data extracted included authors, country, year of publication, characteristics of patients, pathophysiology, risk factors, clinical manifestations, different diagnostic approaches and treatment modalities.
Conclusion: Accumulating evidence in the current literature indicate that vitamin D deficiency is highly prevalent among patients with cognitive impairment, and that low vitamin D status may negatively impact cognition and that hypovitaminosis D is usually associated with increased risk of developing AD and dementia. Nevertheless, while vitamin D supplementation is safe for those with cognitive impairment, there is no solid proof that they will see significant improvement in their symptoms.
  
Keywords
Cognitive Function; Vitamin D; Dementia; Alzheimer’s Disease; hypovitaminosis D; VDR; 25-hydroxyvitamin D (25(OH)D)
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