Mitochondrial Translocase Expression Profile in Renal Cancer

Soliman, Belal Ahmed; Ali, Mohamed Hassany; Toraih, Eman Ali; Ahmed, Mohamed Abdelhamid Hasan

doi:10.12816/0044346

Mitochondrial Translocase Expression Profile in Renal Cancer

Document Type : Original Article

Authors

¹ Department of Zoology, Faculty of Science, Suez Canal University

² 2 Department of Histology and Genetics, Faculty of Medicine, Suez Canal University

³ Department of Pathology, Faculty of Medicine, Suez Canal University

10.12816/0044346

Abstract

Background: mitochondrial appropriate function depends on ideal mitochondrial translocation machinery, of which translocase of outer mitochondrial membrane (TOMM) have a vital role in normal functioning cell. Any disturbance in the translocation machinery leads to either tumorigenesis or apoptosis.
Aim of the work: This study aimed to investigate the expression of TOMM34 in renal cell carcinoma (RCC). TOMM34 expression was assessed in 42 samples of RCC patients using immunohistochemistry technique.
Results: immunohistochemical staining revealed significant accumulation of TOMM34 protein in RCC cases compared to their corresponding non-cancerous renal tissues. TOMM34 protein expression was significantly associated with age and gender categories in contrast to the other clinicopathological features.
Conclusion: according to protein expression level this study demonstrated that TOMM34 is a marker of poor outcome in RCC.

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