Shams El Deen, S. (2020). Renal Impairment and Nonalcoholic Fatty Liver Disease. Disease – Disease Relationship. The Egyptian Journal of Hospital Medicine, 80(3), 1003-1007. doi: 10.21608/ejhm.2020.106016
Said Abd Elbaky Gad Shams El Deen. "Renal Impairment and Nonalcoholic Fatty Liver Disease. Disease – Disease Relationship". The Egyptian Journal of Hospital Medicine, 80, 3, 2020, 1003-1007. doi: 10.21608/ejhm.2020.106016
Shams El Deen, S. (2020). 'Renal Impairment and Nonalcoholic Fatty Liver Disease. Disease – Disease Relationship', The Egyptian Journal of Hospital Medicine, 80(3), pp. 1003-1007. doi: 10.21608/ejhm.2020.106016
Shams El Deen, S. Renal Impairment and Nonalcoholic Fatty Liver Disease. Disease – Disease Relationship. The Egyptian Journal of Hospital Medicine, 2020; 80(3): 1003-1007. doi: 10.21608/ejhm.2020.106016
Department of Internal Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) has emerged as serious growing global health problem worldwide and its association with the progression of renal impairment (RI). Accumulating evidence suggests that NAFLD and RI are sharing the same cardio metabolic risk factors. Objective: to evaluate and investigate the confounding factors sharing in the relation between NAFLD and renal impairment (RI). Patients and Methods: 250 Egyptian patients with NAFLD were investigated for creatinine, ALT, AST, lipid profile, fasting blood sugar. Questionnaire and physical examination were done to explore the relationship between NAFLD and RI. Result: HA1C was 6.0±0.31, cholesterol 210.05±36.67, triglyceride 162.59±35.06, LDL 146.02±16.7 and HDL 43.23±6.15. AST and ALT were 34.12±4.28 and 35.34±4.8 respectively. ALP was 72.49±6.56, Cr 0.99±0.11, urea 29.16±9.41 and e-GFR 89.67±9.95. 39.2% were smokers 39.6% were Hypertensive, 60.8% had dyslipidemia and 27.6% had metabolic syndrome. 22.4% were cardiac patients and asthma represented 17.2% of the studied group. Renal impairment group was significantly associated with higher age and higher HA1C and also with higher Cr and urea but with lower GFR. We found also significant association between RI and males, hypertension, dyslipidemia, metabolic syndrome and asthma, with no other significant relation found.
Conclusion: There is strong and close association between factors and precipitating factors.
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