Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Osman, M., Shahin, R., Elzefzafy, W., Ghazzawi, M. (2018). Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease. The Egyptian Journal of Hospital Medicine, 72(8), 5026-5033. doi: 10.21608/ejhm.2018.10282
Magda H. Osman; Radwa S. Shahin; Wafaa M. Elzefzafy; Maha R. Ghazzawi. "Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease". The Egyptian Journal of Hospital Medicine, 72, 8, 2018, 5026-5033. doi: 10.21608/ejhm.2018.10282
Osman, M., Shahin, R., Elzefzafy, W., Ghazzawi, M. (2018). 'Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease', The Egyptian Journal of Hospital Medicine, 72(8), pp. 5026-5033. doi: 10.21608/ejhm.2018.10282
Osman, M., Shahin, R., Elzefzafy, W., Ghazzawi, M. Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease. The Egyptian Journal of Hospital Medicine, 2018; 72(8): 5026-5033. doi: 10.21608/ejhm.2018.10282

Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease

Article 13, Volume 72, Issue 8, July 2018, Page 5026-5033  XML PDF (482.23 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.10282
View on SCiNiTO View on SCiNiTO
Authors
Magda H. Osman1; Radwa S. Shahin1; Wafaa M. Elzefzafy2; Maha R. Ghazzawi email 1
1Department of Clinical and Chemical Pathology, Faculty of Medicine (for Girls), Al-Azhar University
2Department of Tropical Medicine, Faculty of Medicine (for Girls), Al-Azhar University
Abstract
Aim of the work: to determine the role of Interleukin-10 (IL-10) polymorphism (rs 1800896) and Transforming Growth Factor-Beta-1(TGF-β1) polymorphism (509 CT) as markers for cirrhosis in Egyptian patients with chronic liver disease. Subjects and Methods: This case-control study was carried out on selected patients admitted to Tropical medicine department, Al Zahraa University Hospital during the period from March 2016 to April 2017. Genotyping of IL-10 (rs 1800896) and TGF-β1 (509 CT) polymorphisms were performed using real-time polymerase chain reaction (PCR) technique. Results: There was significant increase in IL10 and TGF β1 509 gene polymorphisms in compensated and de-compensated groups as compared to control group. Conclusion: Interleukin 10 rs 1800896 gene polymorphism and TGF β1 509 gene polymorphism are associated with risk of liver cirrhosis in patients with chronic hepatitis C virus infection. These findings could be useful for future screening for early detection of liver cirrhosis.
Keywords
IL-10; Polymorphism; TGF Beta; Chronic liver disease
Statistics
Article View: 172
PDF Download: 401