2024-03-29T01:26:11Z
https://ejhm.journals.ekb.eg/?_action=export&rf=summon&issue=3314
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Assessment of Asthma Control in a Sample of Asthmatic Patientsin Taif City, Saudi Arabia
Nesriene
El Margoushy
Sahar Musarri
Alkhald
Nawal Zewaid
Al Khaldi
Nihad
El Nashar
Background: asthma Control Test (ACT) Questionnaire is developed to meet the guidelines internationally accepted for asthma management by measuring adequacy and any alteration in control of asthma, occurring spontaneously or after starting asthma management. Objectives: toassess control of asthma in a sample of patients diagnosed as asthmatics in Taif City based on Asthma Control Test (ACT) Methods: fifty asthmatic patients, from those attending the out patients clinic in King Abdul Aziz Specialized hospital and chest hospital in Taif city, were included in this study in the period from July to December, 2013. Patients were subjected to: full clinical history and examination for clinical classification of the disease and to recognize controlled from uncontrolled patients; review for the treatment plan for each patient; (ACT) questionnaire was used to identify patients with poorly controlled asthma. Results: clinical classification of asthma showed that 20% of patients had intermittent asthma, 24% had mild persistent asthma, 32 % had moderately persistent asthma and 24% of patients got severe persistent asthma. According to ACT only 24% of patients were controlled, while the rest of patients 76% were considered uncontrolled. Conclusion: ACT was found to be a reliable tool for assessment of uncontrolled asthmatic patients when implemented in Taif city. Recommendations: conduct more studies in different geographical areas to assess effectiveness of the AST questionnaire in different situations and different asthmatic patients.
Asthma
Asthmatic Patients
Taif City
2016
01
01
1
8
https://ejhm.journals.ekb.eg/article_15379_e4bc242977e79219075361f0a28e5969.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
The Fundamental Role Played by Cell Cycle Proteins in Controlling Cell Proliferation in Chronic Hepatitis C Virus Infection.
Saadia
Farid
Laila
Rashed
Samya
Sweilam
Background: examining the alteration of cell cycle genes in early hepatitis C virus (HCV) found that altered expression of mitotic checkpoint genes, MAD2L1, KNTC1, CDC16 and CDC34, KNTC1 known as “rough deal protein” (ROD) is part of a complex involved in elaborating an inhibitory signal due to improper chromosomal aligment during cell division.
Aim of the work: attempt for the identification of proteins (genes), which act as predictive factors to identify patients with high risk of cell transformation and HCC development.
Patients and methods: fifty three patients with chronic HCV infection, age ranged between 18 and 58 years, time of assessment was before starting therapy of hepatitis C at the National Hepatology and Tropical Medicine Research Institute. Ten healthy individuals were included to serve as controls. All the patients and controls were subjected to the following: history, clinical examination, abdominal ultrasonography, and collection of blood samples for routine laboratory investigation; CBCs. Liver biopsy was done to all patients and controls, patients revealed mild fibrosis (Metavir fibrosis scores from F1 to F3). Also, we used freshly frozen liver biopsies mRNA levels with perspective protein levels of four genes: P27, P15, KNTC1, MAD2L1. Results: significant association of P27, P15, KNTC1 and MAD2L-1 with the progression of liver fibrosis in chronic HCV liver biopsy was found. Conclusion: there is altered gene expression in HCV-associated liver disease. Recommendations: the emerging interest of hepatologists in the influence of genetic factors in HCV. Evaluation of the expression of key proteins related to the cell cycle and apoptosis in chronically infected patients with HCV would be of significance to understand disease pathogenesis, and will help in identifying novel prognostic indicators.
Cell cycle proteins P27
P15
KNTC1 and MAD2L-1
cell division
mitosis
HCV
2016
01
01
9
17
https://ejhm.journals.ekb.eg/article_15380_c2606fc61f1c12a13dac1f5fe8f875b5.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Mitomycin-C Induced Genetoxic Effect in Lymphocytes and Histological Alterations in Testes of Male Albino Mice
Nagla Zaky Ibrahim
El -Alfy
Mahmoud Fathy
Mahmoud
Ayman Mohammad
Abdullah
Background:mitomycin-C (MC) is an anti-cancer drug against several tumor types, including colon, breast and head and neck. In this demonstration, the genotoxic effects of mitomycin-C on DNA content and testicular tissue of male albino mice Mus musculus were studied.Materials & Methods: mitomycin-C treated animal was injected intrapretonialy with tested doses of mitomycin-C single time at the first day of the experiment. Comet assay was used to detect the DNA damage in mice lymphocytes and the mean of total comet score was increased by dose and time among all treated groups. Results:the histological alterations caused in the testis of mice after mitomycin-C treatment displayed variable changes in both the seminiferous tubules and the interstitial tissue. Changes in seminiferous tubules were represented by hypoplasia of the germinal epithelium and spermatogenic arrest at various stages of spermatogenesis. The most prominent changes reported in the intertubular tissue were represented by the presence of a homogeneous and intensely eosinophilic ground substance in the interstitial areas, congestion of blood vessels as well as haemorrhage. The histological changes were also significantly increased by time and dose.
mitomycin-C
Chemotherapy
Comet assay
DNA
testicular histopathological alterations
2016
01
01
18
27
https://ejhm.journals.ekb.eg/article_15381_64dd9e3f4cb5931af70486264b9a1b06.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Histopathological and Immunohistochemical Changes Induced by BisphenolA in Reproductive Tissues of Female Rat
Alazzouni
A. S
Hassan
B. N
Al Jalaud
N. A
Background: Bisphenol A (BPA) is an environmental chemical that has beenwidely used in the manufacture of polycarbonate plastics andepoxy resins for many years. Due to its major applications inthe production of plastic food or beverage containers andthe coating of food cans, people of different ages are inevitably exposed to BPA in daily life. It is a contaminant with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells. Aim of the work: the present study was designated to evaluate the histopathological and immunohistochemical effect of BPA on the histoarchitecture of pituitary ,adrenal,ovarian and uterine axis of female albino rats and the ameliorative effect of antiestrogen drug and stem enhance Experimental model and methods: 20 female albino rats weighing 100 – 120 g. were kept under observation for about 15 days before the onset of the experiment for adaptation, then the rats were classified into 4 groups 5 rats for each , the first group was left without any treatment for 30 days as negative control group , the second group was administered with 20 mg/kg.bw of BPA for 15 consecutive days as positive control, the third group administered with 20 mg/kg.bw of BPA for 15 consecutive days and then treated withantiestrogen drug as 0.1 mg/100gm.bw for 15 day, the fourth group administered with the same dose for the same period and the treated with stem enhance (4.5 mg/100.bw) for 15 days.All rats are scarified and organs were histologically examined after processing
Results:the results showed thatPA has a histopathological effects on vital organs (pituitary, adrenal,ovary,oviduct and uterus) even for a short period with minimal ameliorative effect of antiestrogen drug and stem enhance.
bisphenol A – xenoestrogen – antiestrogen – stem enhance
2016
01
01
28
36
https://ejhm.journals.ekb.eg/article_15382_30c7e6c5ed392e034d615d7d2eb8fe46.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Relation between Serum Levels of Vitamin D and Echocardiographic Determinants of Systolic and Diastolic Functions in Patients with and without Cardiorenal Syndrome
Ahmed Ibrahim El-Desoky
Khalil
Ramzy Hamed
El-Mawardy
Haitham Galal
Mohammed
Mohammed Ahmed
Abdel Rahman
Tarek Rasheed
Mohamed
Background: vitamin D is a fat-soluble vitamin; it has skeletal and non-skeletal functions. The effect of Vitamin D on CV disease had several mechanisms including elevated PTH and Calcium-phosphate metabolism. It decreases the pro- remodeling of Angiotensin II on the cardiomyocytes.
The Objectives: to study relation between serum levels of vitamin D and echocardiographic determinants of systolic and diastolic functions in patients with and without cardio-renal syndrome.
Patients and Methods: prospective study was conducted on 90 patients of all age groups and both sexes, admitted to Ain-Shams University hospital. The study included 3 groups of patients: Group 1: systolic dysfunction and renal insufficiency (30 patients), Group 2: systolic dysfunction only (30 patients). Group 3: renal insufficiency only (30 patients), in addition 10 healthy controls were taken as controls. Patients were subjected to full comprehensive echocardiography and KFT with estimation of creatinine clearance, and Vitamin D level that was statistically studied against echocardiographic parameters of cardiac systolic and diastolic function. Results: our study found that, compared to patients with normal vitamin D level, patients with vitamin D deficiency (defined as having vitamin D level <20 ng/ml) had significantly higher ventricular thickness (IVS, PW and mean wall thickness) (P value < 0.001), and higher LV mass which seems to be linked eventually to worse outcomes with no significant impact on worsening Diastolic dysfunction. A ROC curve was done revealing a sensitivity of 80% for the mean wall thickness (≥ 10 mm) to identify patients with vitamin D deficiency.
Conclusion: Vitamin D deficiency was associated with ventricular hypertrophy with worsening outcomes with no impact on diastolic function.
Key words:
vitamin D deficiency
Systolic heart failure
Diastolic Dysfunction
2016
01
01
37
50
https://ejhm.journals.ekb.eg/article_15383_bf1ce2afde66ecc133b35992530e413b.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Radiofrequency Catheter Ablation of Premature Ventricular Beats among Egyptians: Predictors of Success and Recurrence
Mustafa Mohamed
Abdelmonaem
Wagdy Abdelhamid
Galal
Hayam Mohamed
Eldamenhoury
Mohamed Amin
Abdelhamid
Rania Samir
Ahmed
Haitham Abd El Fattah
Badran
Background: Premature ventricular beats (PVBs) are early depolarization of the myocardium originating in the ventricle, the prognosis in patients with frequent PVBs and no obvious organic heart disease is usually very good. However, many patients are severely symptomatic with impaired quality of life.
Aim of the study: We aimed at our study to assess the success of radiofrequency catheter ablation of monomorphic PVB and its impact on improvement of left ventricular (LV) systolic functions.
Patients and Methods: The current study was conducted on 40 patients with frequent symptomatic monomorphic PVBs, candidate for PVB radiofrequency catheter ablation in cardiology department, Ain Shams University, between 2013 and 2015. All patients were subjected to thorough history taking, complete general and local examination, conventional 2D echocardiography and pre-procedural Holter ECG monitoring. Patients were divided to two groups (20 patients in each group) according to the presence or absence of structural heart disease. Electrophysiological mapping and ablation was done for all patients, and their clinical, electrophysiological and procedural aspects were analyzed. Follow up echocardiography and Holter ECG monitoring was done 3-6 months later to assess recurrence and impact on LV internal dimensions and systolic functions.
Results: Acute success was achieved in 35 patients (87.5%), and long term success was achieved in 30 patients (75%), with elimination of PVBs and distressing symptoms among group of patients with procedural success. Presence of structural heart disease was not related statistically to procedural failure or long term recurrence. Magnitude of reduction of PVB burden had significant correlation with improvement of systolic functions (P=0.04). Significant improvement of echocardiographic parameters was witnessed among group with baseline LV systolic dysfunction.
Conclusions: Radiofrequency catheter ablation is an effective and safe therapeutic tool for frequent monomorphic PVBs and should be addressed as 1st line option for reversal of PVB induced LV systolic dysfunction.
PVB
electrophysiology
Radiofrequency ablation
2016
01
01
51
56
https://ejhm.journals.ekb.eg/article_15384_6ef97cf0150bf940f7216ebe9af69159.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
The Impact of Transradial versus Transfemoral Approach for Percutaneous Coronary Intervention on the Outcome of Patients Presenting with Acute Coronary Syndrome
Ahmed Ibrahim
Nassar
Ahmed Mohamed
El Mahmoudy
Ahmed Mohamed
El Missiry
Shehab Adel
El Etriby
Background: the transfemoral approach (TFA) has been until presently the main-stay for arterial access PCI in the setting of acute STEMI, while the transradial approach (TRA) is gaining ground in elective as well as primary procedures.
Objectives: to assess the impact of transradial versus transfemoral approach for PCI on the outcome of patients presenting with acute coronary syndrome.
Patients and Methods: prospective study was conducted on 100 patients presenting to Ain Shams University Hospitals Coronary Care Unit (CCU) with recent onset acute coronary syndrome (whether unstable angina (UA)/non–ST-segment-elevation MI (NSTEMI) or ST-segment-elevation MI (STEMI)) undergoing revascularization via percutaneous coronary intervention (PCI). Patients were randomized into 2 equal groups, for the first group PCI was performed via TFA while for the second group via TRA.
Results: our study found that, with TRA we get less bleeding, less local vascular complications [8 (16%) vs 2 (4%), p=0.045] & less amount of dye used (169.60 ± 21.28 versus 187.00 ± 37.65 ml, p=0.006) without significant increase in fluoroscopy time (10.86 ±4.88 versus 9.76 ±4.74 mins, p=0.256) or radiation exposure. Although there was no significant difference in mortality and morbidity, TRA offers the patient a more simple procedure with less hospital stay (3.4 ±0.948 versus 3.86 ±0.808 days, p<0.01).
Conclusion: radial artery access is a safe and effective approach for management of ACS. If performed by experienced operators, TRA should be the standard access in managing ACS specifically in STEMI.
Acute Coronary Syndrome
transfemoral approach
transradial approach
2016
01
01
57
64
https://ejhm.journals.ekb.eg/article_15385_1950e817a1521e43f4baf75cb57bbb7a.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Anticancer Potential of Bee Venom and Propolis Combined Treatment on Human Breast Adenocarcinoma Cell Line (MCF-7)
Eman G. E.
Helal
Nora Abdulaziz
Al Jalaud
Islam M.
El-Garawani
Anwaar Alkamel
Kahwash
Backgrounds: Natural remedies were used for cancer treatments, particular breast cancer. Also, the consumption of food products containing high amount of flavonoids and antioxidants had reported to lower the risk of various cancers. Bee venom (BV) and propolis were produced by honey bee. They were characterized by naturopathic formulation, affordability and containing high amount of antioxidants. Moreover, they were used safely since ancient times globally. Although that, there is no information about the synergistic or antagonistic anticancer effects of their combination. This study was designed to evaluate cytotoxic and pro-apoptotic effects of BV, propolis, and their combination on breast cancer (MCF-7) cells. Materials and Methods: As preliminary study, MCF-7 cells were treated with BV (5, 10, and 20µg/ml) and propolis (50, 150, and 450µg/ml) to specify the desired combination doses of each treatment with no anticancer effect individually. Consequently, doses of (5µg/ml BV+ 50µg/ml propolis and 5µg/ml BV+ 150µg/ml propolis) were chosen to evaluate the possible synergistic anticancer potential between them. All groups in this study were examined at 2, 4, and 12 hours intervals. The morphological changes were evaluated by acridine orange/ ethidium bromide dual fluorescent staining and Giemsa staining to reveal the formation of apoptotic bodies or nuclear condensation and cytoplasmic blebbing, respectively. DNA fragmentation assay was also carried out to record the reduction in DNA content and apoptosis. Bcl-2 expression, cytoplasmic anti-apoptotic marker, was used to prove the apoptotic properties, and autophagic cell death by florescent microscopy was evaluated also. Results: Morphological observation by inverted and florescent microscopy revealed apoptotic cell death under exposure to BV (10 and 20µg/ml) and propolis (450µg/ml). On the other hand, the results of combined treatments revealed significant morphological alterations after fluorescent and Giemsa staining. Apoptotic DNA fragmentation was clearly observed and Bcl-2 recoded significant down regulation which proved the apoptotic properties of combined treatments. Additionally, autophagic degradation results also supported the occurrence of stress on treated cells leading finally to cell death. All results of powerful anticancer potential were obvious among all combined-treated groups in dose and time dependent manner. This clear that, the combined treatments have possible synergistic effect which, propose it as potential candidates to be used in development of chemotherapy.
Bee venom
Propolis
combination
MCF-7
autophagy
and apoptosis
2016
01
01
65
76
https://ejhm.journals.ekb.eg/article_15386_9e6a4d92e9a5df479ba355f7c94e5390.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Role of Hypovitaminosis D in the Incidence and Complications of Diabetes Mellitus in Rats
Hanaa H.
EL-Sayed
Ayman E
El-Adawy
Soad H
Mostafa
Areej A
Yassin
Background: Diabetes mellitus continues to be a public health concern. Vitamin D had sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of this study was to investigate the effect of vitamin D (deficiency & treatment) with alteration in fasting plasma glucose, insulin resistance in alloxan injected rat. Materials and methods: The experiment was carried out using 40 male albino rats (Sprague Dawley) weighing 150±10g. Animals were randomly divided into three groups; first group fed standard diet as a negative control group. Diabetic group injected subcutaneously by alloxan, and fed on standard diet. The third group fed standard diet without vitamin D for two weeks. After that glucose and insulin were determined in each rat of all groups to insure alteration in fasting plasma glucose, insulin resistance, Homeostasis model assessment insulin resistance (HOMA-IR)was calculated. Then the third group was divided to two subgroups. The first subgroup fed basil diet with required vitamin D; while the second subgroup fed standard diet with double dose vitamin D. At the end experiment (4 weeks), glucose, insulin, lipid profile, liver and renal functions were determined in blood and serum, while (HOMA-IR)and LDL were calculated for normal, diabetic group and both treatment subgroups. Results: Vitamin D deficiency group had the nearest results to the diabetic group injected with alloxan group in: insulin, glucose and HOMA-IR. Other groups had lower level than the other two groups in the same parameter. Our data explained the improvement in glucose level after feeding with vitamin D. Diabetic group injected with alloxan had increased in liver enzymes, renal function and lipid profile compared with other groups and showed variable changes in histopathological examination. Conclusion: Vitamin D deficiency status is associated with a higher risk of type 2 diabetes. Vitamin D improves glucose tolerance and insulin sensitivity. Vitamin D has also been shown to reduce the risk of diabetes associated complications.
Alloxan – Diabetic- glucose tolerance- Insulin sensitivity .Vitamin D
2016
01
01
77
88
https://ejhm.journals.ekb.eg/article_15387_7830216f775d48016996599c89443f6f.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
An Audit Evaluating Anticoagulation Clinic Managed by Clinical Pharmacists in Jordan
Nadia A.
Al-Omari
Nairooz H.
Al-Momany
Diana A.
Ibrahim
Ruba B.
Ayesh
Hana A.
Al-Sarayreh
Hiam S.
Al-Haqesh
Background and Objectives :Warfarin is the most widely prescribed oral anticoagulant; it is highly effective for the treatment and prevention of venous and arterial thrombosis. The beneficial outcomes of warfarin therapy are dependent upon achieving and maintaining an optimal international normalized ratio (INR) therapeutic range. The aim of this study was to evaluate the impact of our newly established clinic at Queen Alia Heart Institute (QAHI) in the Royal Medical Services (RMS), Jordan.
Patients and Methods:An observational prospective study was carried out in a newly established anticoagulation clinic managed by two clinical pharmacists and one nutritionist in QAHI since September 2013 until June 2014. The patients (no= 250) who were on warfarin for at least two months referred to the clinic were included in our study. All patients or their care givers received a 45 minutes educational session and a warfarin booklet. Then they were followed up regularly for achieving and maintaining the target INR and developing any adverse events related either too high or low INR (>4.5 or <1.5, respectively).Results:The age range of this group of the patients who were referred to t he clinic was wide, 5-81 years. 65% of them were males, with the most common indications for Warfarin were aortic and mitral valves replacement, and atrial fibrillation.72% of the patients were not achieving therapeutic (T) INR 43% of them achieve the TINR within the first week, 28% within the second week, 17% within the third, 4% within the fourth and 8% exceeded 4 weeks. The proportion of time within TINR for all the patients during the whole period was 75%. Only 7% of the patients had low INR, <1.5 and 5% had high INR, >4.5 for one visit. No major thromboembolic or hemorrhagic events were reported.
Conclusion:The newly established clinic had achieved a considerable encouraging results and feedbacks in the short period of time since it had been established.
Warfarin
international normalized ratio (INR)
atrial fibrillation (AF)
Thrombosis
anticoagulation
2016
01
01
89
94
https://ejhm.journals.ekb.eg/article_15388_812c364fb9ed91502d76e85aa8edf3e1.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Hepatoprotective and antidiabetic effects of apple cider vinegar (A Prophetic Medicine Remedy) on the liver of male rats
Nassar Ayoub Abdellatif
Omar
Amal Nor Edeen Ahmad
Allithy
Salah Mohamed
El Sayed
Background: Diabetes mellitus is associated with biochemical and pathological alterations in the liver. The aim of this study was to investigate the effects of apple cider vinegar (ACV) on serum biochemical markers and histopathological changes in the liver of diabetic rats for 30 days. Effects were evaluated using streptozotocin (STZ)-induced diabetic rats as an experimental model. Materials and methods: Diabetes mellitus was induced by a single dose of STZ (65 mg/kg) given intraperitoneally. Thirty wistar rats were divided into three groups: control group, STZ-treated group and STZ plus ACV treated group (2 ml/kg BW). Animals were sacrificed 30 days post treatment. Results: Biochemical results indicated that, ACV caused a significant decrease in glucose, TC, LDL-c and a significant increase in HDL-c. Histopathological examination of the liver sections of diabetic rats showed fatty changes in the cytoplasm of the hepatocytes in the form of accumulation of lipid droplets, lymphocytic infiltration. Electron microscopic studies revealed aggregations of polymorphic mitochondria with apparent loss of their cristae and condensed matrices. Besides, the rough endoplasmic reticulum was proliferating and fragmented into smaller stacks. The cytoplasm of the hepatocytes exhibited vacuolations and displayed a large number of lipid droplets of different sizes. On the other hand, the liver sections of diabetic rats treated with ACV showed minimal toxic effects due to streptozotocin. These ultrastructural results revealed that treatment of diabetic rats with ACV led to apparent recovery of the injured hepatocytes. In prophetic medicine, Prophet Muhammad peace is upon him strongly recommended eating vinegar in the Prophetic Hadeeth: "vinegar is the best edible".
Conclusion: This study showed that ACV, in early stages of diabetes induction- can decrease the destructive progress of diabetes and cause hepatoprotection against the metabolic damages resulting from streptozotocin- induced diabetes mellitus.
streptozotocin
Diabetes mellitus
apple cider vinegar
Liver
rat
2016
01
01
95
104
https://ejhm.journals.ekb.eg/article_15389_8d12e04bc9d9dbc9625a827b91bff3e8.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats.
Gehan A.
Youssef
Background Ginseng, an ancient and famous medicinal herb in the Orient, has been used as a valuable tonic and for the treatment of various diseases including hepatic disorders. Ginseng extracts and individual ginsenosides have shown a wide array of beneficial role in the regulation of regular liver functions and the treatment of liver disorders.
Objective: This study tries to determine the hepatoprotective , antioxidant and anti-inflammatory effects of ginseng on Methotrexate (MTX)-induced hepatotoxicity
Materials and Methods: forty rats (weigh 150-180 g) were used. The rats were kept in animal house for one week and had access to water and food . Temperature was kept at 37 °C. After one week, the rats were randomly divided into four equal groups: Group (A) (control) received normal saline ; group (B )received Ginseng(1.8 ml/kg/day) orally ; group( C) received MTX (100 μg/kg) intraperitoneally and group (D) received MTX (100 μg/kg) intraperitoneally with ginseng (1.8 ml/kg/day) orally. After six weeks, the rats were decapitated and evaluation of liver function was done.
Results: Ginseng treatment markedly suppressed the serum alanine aminotransferase (ALT) , aspartate aminotransferase (AST) and serum gama glutamil transpeptidase (λGTP) activiteis . Ginseng was attributed to stimulate anti-oxidant protein contents, such as glutathione peroxidase (GPX). The marked increase of proinflammatory cytokines ( TNF α ) in MTX treated rats group was additionally attenuated by ginseng,
Conclusion : Ginseng effectively prevent liver injury, mainly through down regulation of oxidative stress and inflammatory response.
Ginseng
Methotrexate
Liver
anti-inflammatory activity
antioxidant
2016
01
01
105
108
https://ejhm.journals.ekb.eg/article_15390_12864e1e713251c06d0230efc0dbc062.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2016
62
1
Sodium Chloride Stress Induced Morphological Changes in Some Halotolerant Fungi
Mona S. S.
Al Tamie
Materials and methods: Nine fungal isolates namely Emericill anidulans, Mucor racemosus , Alternaria pluriseptata Penicillium canescens, Syncephalastrum racemosum, Aspergillus fumigatus, Alternaria chlamydospora, Aspergillus parasiticus and Ulocladium atrum were isolated from AL – SHEGA area at AL- QASSIM region. Results: The influence of different sodium chloride concentrations on the growth rate, morphological and ultrastructure were studied. Considerable differences in their growth rate and morphology were detected on medium containing different concentrations of sodium chloride (NaCl). Low growth rates were obseved on high NaCl concentrations . At 15 % NaCl, low growth of Emericill anidulans, Penicillium canescens, Syncephalastrum racemosum, Aspergillus parasiticus and Mucor racemosus was detected , whereas all fungal isolates were failed to grow at 20% NaCl. Scanning Electron Microscope (SEM) revealed that all fungal asexual reproduction organs were metamorphosed at higher NaCl concentration, fungal heads and sporangia were speculated or elongated. Sporangiophores and conidiophores were shortened and dwarfed ,little number of conidia or spores were detected.
halotolerant fungi
salt stress
SEM.sodium chloride
Morphology
2016
01
01
109
126
https://ejhm.journals.ekb.eg/article_15391_3096d9199ac42f7ffd4a2440e19564ce.pdf