Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Influence of Protein Malnutrition on Prenatal Toxicity of Fluoxetine
229
245
EN
Hamed
M.R
National Organization for Drug Control and Research Ain Shams University
Asmaa M.
Kandil
National Organization for Drug Control and Research Ain Shams University
Zeinab M. A.
Abbas
National Organization for Drug Control and Research Ain Shams University
El shorbagy
O
Institute of Postgraduate childhood studies. Ain Shams University
10.21608/ejhm.2009.17561
<strong>Background:</strong> Protein malnutrition is prevalent in developing countries. Gestational and neonatal malnutrition were considered to contribute to the development of chronic diseases in adulthood.
The aim of the present work was to investigate the influence of prenatal protein malnutrition on embryo -fetal toxic effects of the commonly used antidepressant drug Fluoxetine.
<strong>Methods</strong>: The pregnant rats were divided into two sets: normally fed and protein malnourished. Each set was sub- divided into five groups of 10-14 animals each. Starting from 1st day of pregnancy, animals were fed with standard diet (20% casein). Animals specified for protein malnutrition were switched to protein deficient diet (8%casein) from the 7th day of gestation throughout the end of pregnancy. Fluoxetine hydrochloride was administrated orally in the dose levels 2mg and 8mg /kg/day from day 7 to 14 and from day 15 to 20 of gestation. At the 20<sup>th</sup> day of gestation the outcome of pregnancy was examined immediately for viability and fetal growth parameters, placental weight as well as fetal external anomalies. Hb, RBCs count, total and differential WBCs and platelets counts were estimated. Fetuses from each group were subjected to skeletal examinations using the Alcian blue and Alizarin red technique.
<strong>Result</strong>:The results showed that prenatal protein malnutrition and administration of Fluoxetine in the high used dose level 8mg /kg were found to cause significant decrease in fetal growth parameters, and placental weights increase in resorption of fetuses multiple hematomas.
Blood examination of protein malnourished fetuses and groups treated with fluoxetine revealed significant decrease in Hb level; RBCs count & platelets, however, total the leucocytic count was increase. The incidence of skeletal abnormalities was more obvious when fluoxetine was administrated during embryogenesis period.
<strong> </strong>
Protein Malnutrition,Prenatal,fluoxetine
https://ejhm.journals.ekb.eg/article_17561.html
https://ejhm.journals.ekb.eg/article_17561_6a3c5aaa8bcb6cca520c6035c45b9b1e.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Effect of Some Slimming Drugs on Some Biochemical and Physiological Parameters of Albino Rats
246
253
EN
Eman G.E.
Helal
Zoology dep., Faculty of Science, Al-Azhar University, Egypt
Ali A.
Shati
Life Science Dep., Faculty of Science, King Khalid University, KSA.
Fahmy G.
Elsaid
Zoology Dep., Faculty of Science, Mansoura University, Egypt.
10.21608/ejhm.2009.17563
<strong> Background:</strong><strong>The slimming drugs differ in their nature, where apple-lite is a fully natural substance, mirapro-N is a chemical substance and tenuate is a synthetic foamy filler substance. The study aimed to search the physiological and biochemical changes accompanied with these drugs on rats.</strong>
<strong> Methods:</strong><strong>Forty adult male albino rats (130±20g) were divided into four groups, ten on each treated group and ten for the control one. The apple-lite group treated with 3.5mg/100 g body weight, the mirapro-N group treated with 0.14mg/100g body weight and the tenuate group treated with 0.1 mg/100 g body weight. </strong>
<strong> Results: </strong><strong>The treated groups showed a significant changes in the lipid and protein profiles, enzymatic activities, in the skin folds and the percentage of body weight compared to the control group.</strong>
<strong> In conclusion</strong><strong>, the slimming drugs showed a change in skin folds thickness and in percentage of organ’s weight to body weight and also showed a deflection in the investigated biochemical parameters. </strong>
<strong> </strong>
Slimming drugs,tenuate,apple-lite,mirapro-N,Lipid profile,liver function,skin folds
https://ejhm.journals.ekb.eg/article_17563.html
https://ejhm.journals.ekb.eg/article_17563_2ab6e12dafbfd51571456a10d89e7d59.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
EVALUATION OF THE PROTECTIVE EFFECTS OF JOJOBA EXTRACT AGAINST FUMONISIN TOXICITY IN RATS
254
270
EN
Mohamed
Reda
Botany Dept, Faculty of Science, Benha University, Benha, Egyp
Hafiza A.
Sharaf
Pathology Dept., National Research Center, Dokki, Cairo, Egypt
Elhady M.
Gaber
Nutrition Institute, Cairo, Egypt
El-Sayed M.
Embaby
Plant Pathology Dept, ., National Research Center, Dokki, Cairo, Egypt
Noura
El-Katan
Agouza Hospital, Agouza, Giza, Egypt
Mosaad A.
Abdel-Wahhab
Food Toxicology & Contaminants Dept., National Research Center, Dokki, Cairo, Egypt,
10.21608/ejhm.2009.17565
<strong>Aim of the work:</strong> The current study was conducted to evaluate the protective effect of the ethanolic extract of jojoba in rats treated with fumonisin. <strong>Material and Method</strong>: Forty mature male Sprague–Dawley rats were divided into four groups included the control groups and the groups treated with fumonisin-contaminated cultural materials (60 mg/L), the group treated orally with jojoba extract (5 mg/kg b.w) and the group treated with fumonisin and the extract. <strong>Results</strong>: the results indicated that fumonisin induced a significant decrease in RBCs, HB, platelets, WBCs and triglycerides accompanied with a significant increase in all the other biochemical parameters tested. Moreover, animals treated with fumonisin alone showed severe pathological and histochemical changes in the liver tissues. Animals treated with jojoba extract alone were comparable to the controls regarding the haematological, the biochemical parameters, the histological structure and histochemical picture of the liver. <strong>In conclusion</strong>: The extract contracted the toxic effects of fumonisin and succeeded to normalize all the parameters tested and improve the histological and histochemical structure of the liver.
<strong> </strong>
Fumonisin,Jojoba,antioxidant,Liver,toxicity
https://ejhm.journals.ekb.eg/article_17565.html
https://ejhm.journals.ekb.eg/article_17565_8ec069363828e1cb3db1ca6fdf92df08.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
STRUCTURAL CHANGES IN THE PANCREAS OF EXPERIMENTAL DIABETIC RATS UNDER THE EFFECT OF SOME HYPOGLYCEMIC MEDICINAL PLANTS
271
287
EN
Ashraf M.
Moustafa
Department of Histology, Faculty of Medicine Al-Azhar University
Eman G. E.
Helal
Zoology Department Faculty of Science (Girls) Al-Azhar University
Anwar Al-Kamel
Mohamed
Zoology Department Faculty of Science (Girls) Al-Azhar University
10.21608/ejhm.2009.17572
<strong>Background: </strong>Diabetes is a chronic metabolic disease which affects large number of population all over the world. Such disease is associated with many complications which may leads finally to patient’s mortality. More than 400 traditional medicinal plants have been recorded for helping in controlling such disease. So this study was planned to evaluate the effect of one of the famous plant mixture used in Saudi Arabia and some other Arab countries as hypoglycemic agent.<br /> <strong>Material and methods: </strong>Fourty adult male Albino Rats were divided into 8 experimental groups: The first group was considered as a control group. The rest of groups were affected by induction of experimental diabetes by subcutaneous injection of Alloxan. The second group was consisted of diabetic rats without any treatment.The third group was treated by water mixture of the plants used. The fourth group treated with Nigella sativa while the fifth group treated with Aloe vera. The sixth one treated with Feruls assa foetida. The seventh group was treated with Boswellia carterii Birdw and finally the last group was treated with Commiphora myrrha. The used plant dose was 1ml / 100gm body weight. After four weeks of treatment different physiological parameters were performed including estimation of the body weight, blood sugar level and serum insulin level. Pancreatic samples were obtained and processed for microscopic and quantitative evaluation after staining the prepared sections with both Heamatoxylin and eosin as well as special stain for demonstration of the different pancreatic cells in the Islet of the Langerhans.<br /> <strong>Results: </strong>The obtained results showed that the induced diabetes was diagnosed by laboratory assessment. The usage of the mixture or each plant alone was correct the glucose level,body weight gain and the insulin level. Microscopically there was definite decrease in the number and diameter of beta pancreatic cells in the diabetic group while the other pancreatic cells were not affected (alpha and delta cells).<br /> The use of medicinal plants in the different groups of this study greatly improves such cellular changes and the level of blood sugar level was corrected. The results obtained by the use of Commiphora myrrha was the best when compared with the rest of other plants. Delta cells were reduced in number and diameter with such treatment. <br /> <strong>Conclusions: </strong>It is recommended from such study that the use of the plant mixture as a hypoglycemic agent may be of good results than the use of each plant separately besides repeating such study with the use of variable doses may be helpful in better evaluation for the required doses. <br /> <strong> </strong>
alloxan,Hypoglyceamia,diabetes,pancreas
https://ejhm.journals.ekb.eg/article_17572.html
https://ejhm.journals.ekb.eg/article_17572_d9f53785b263a7cd1a4f9b0402577c17.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Sensitization to Common Food Allergens in Makkah City
288
294
EN
Moufag Mohammed Saeed
Tayeb
King Abdul Aziz University Hospital – Jeddah – Saudi Arabia , Albaha University- Kingdome of Saudi Arabia King Abdul Aziz University Hospital – Jeddah
Emad A
Koshak
King Abdul Aziz University Hospital – Jeddah – Saudi Arabia , Albaha University- Kingdome of Saudi Arabia King Abdul Aziz University Hospital – Jeddah
Majdy Mohammed .A
Qutub
King Abdul Aziz University Hospital – Jeddah – Saudi Arabia , Albaha University- Kingdome of Saudi Arabia King Abdul Aziz University Hospital – Jeddah
10.21608/ejhm.2009.17575
Sensitization to food allergens at Makkah city is not documented. In this study, a retrospective evaluation of a specific IgE (sIgE) test results to common food allergens of 80 patients with suspected food allergy (FA) was conducted. Of these, 51 (63.75%) were female, 29 (36.25%) male, 48 (60.6 %) adult and 31 (39.4 %) pediatric patients. Their ages ranged between 1 month of age and 75 years (mean 27 years and median 30 years). Their common diagnoses were 52 (65 %) atopic dermatitis, 24 (30%) urticaria/angioedema and 4 (5 %) bronchial asthma. Atopic history in the first and second-degree relatives was positive in 35 (43.75 %). The top five food allergens were cocoa 22 (27.5 %), peanuts 14 (17.5%), egg white 12 (15%), milk 10 (12.5%) and strawberry 9 (11.3%). In conclusion, sensitization to common food allergens in Makkah was compatible with worldwide literature except for cocoa and strawberries, which are an unexpected finding that needs further evaluation
https://ejhm.journals.ekb.eg/article_17575.html
https://ejhm.journals.ekb.eg/article_17575_3a1a40b1cee9a7a8f106148a7ac01643.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride
295
308
EN
Enayat A. M.
Omara
Pathology Dept National Research Centre, Dokki, Cairo, Egypt
Somaia A.
Nada
Pharmacology Dept National Research Centre, Dokki, Cairo, Egypt
Hanan G.
Zahran
Clinical Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt
10.21608/ejhm.2009.17577
<span>Aim of the work: </span><span>the present study was conducted to evaluate antioxidant, hepatoprotective, and immuno-stimulant properties of carotenes derived from food byproducts (tomato peels (TPW), mango peels (MP), corn gluten (CG), and agriculture dill waste (DW)), they were selected for their high superoxide dismutase activity (SOD). </span>
<span>Material and methods: </span><span>antioxidant and hepatoprotective effects were investigated in carbon tetrachloride (CCl</span><span>4</span><span>) damaged liver. Rats treated with oral doses of each carotene (25 mg /Kg b.wt.) for 15 days prior CCl</span><span>4 </span><span>administration and 4 days post- CCl</span><span>4</span><span>-treatment.<br /> </span><span>Results: </span><span>all tested carotenes significantly reduced the elevated values of liver function tests (GGT, ALT & AST) in hepatic damaged groups as well as, they had an immuno-stimulate property. They increased IgG levels in normal and liver damaged rats treated with the tested carotenoids. Whereas, IgG level reduced significantly by CCl</span><span>4</span><span>-tereatment. Histopathological examination of the liver tissues exposed to CCl</span><span>4 </span><span>showed inflammatory cell infiltration, necrosis and fibrosis. Glycogen and total protein contents also recorded. Treatments with carotenoids led to an improvement in the histological and histochemical alterations induced by CCl</span><span>4</span><span>. </span>
<span>Conclusion</span><span>, carotenes may play an important role as nutraceutical preparation, specially, when obtained from wastes of food byproducts in which economically of low coast production.<br /> </span><span><br /></span>
antioxidant,Hepatoprotective,histopathology,Nutraceutical,Carotenoids
https://ejhm.journals.ekb.eg/article_17577.html
https://ejhm.journals.ekb.eg/article_17577_11a73455a2930b482278cf4c1debf11c.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
ANTIOXIDANT AND PROTECTIVE EFFECT OF AROMATIC PLANTS BLEND INFUSION AGAINST OXIDATIVE STRESS OF STREPTOZOTOCINE AND CARBON TETRACHLORIDE IN RATS
308
324
EN
Khaled F.
El-massry
Flavour and Aroma Department - National Research Center, Dokki, Cairo, Egypt
Ahmed H.
El-Ghorab
Flavour and Aroma Department - National Research Center, Dokki, Cairo, Egypt
Manal M.
Ramadan
Flavour and Aroma Department - National Research Center, Dokki, Cairo, Egypt
Ahmed M.
Gad
Flavour and Aroma Department - National Research Center, Dokki, Cairo, Egypt
10.21608/ejhm.2009.17579
<strong>Aim of the work:</strong> The present study aimed to use some aromatic plants as ingredients to prepare a healthy drink with an acceptable flavour and taste and to evaluate its chemoprotective activity against oxidative stress induced by streptozotocin (STZ) and carbon tetrachloride (CCl<sub>4</sub>) in rats<strong>. Materials and Methods:</strong> Infusion of guava leaves, linden, ginger, corn silk and chamomile was prepared, its volatiles were isolated and analyzed using GC and GC/MS, sensory evaluation as well as the total phenolic content were determined. The chemoprotective effectiveness of the blend infusion was tested by two separate biological experiments against the oxidative stress of STZ and CCl<sub>4</sub>. Serum glucose level was determine as well as liver function, kidney function, lipid profile, plasma hemoglobin, antioxidant enzymes and malonaldehyde (MDA) in some organs were investigated. <strong>Results:</strong> Thirty nine compounds were identified in the volatiles of blend infusion. The main components were 1,8-cineol (35.97%), cumene (7.12%), guryunene (5.25%), b- patchoulene (4.55%), citronellol (2.97%) and a- zingiberene (1.76%) and these compounds are related to the characteristic volatiles of the different aromatic plants that constitute the blend infusion. The blend infusion exhibits high score for all sensory attributes<br /> <strong>The results</strong> showed that the supplementation with blend infusion to intoxicated rats either with STZ or CCL<sub>4</sub> with blend infusion for four weeks significantly ameliorate most of the toxic effects and protecting pancreas, kidney and liver through improving their antioxidant status. <strong>In conclusion</strong>: The aromatic plants blend infusion was safe and effective in controlling hyperglycemic effects of STZ and improve lipid metabolism as well as its hepatoprotective activity against CCl<sub>4 </sub>by amelioration of the associated biochemical parameters.<br /> <strong> </strong>
aromatic plants,GC-MS,Chemoprotection,Oxidative Stress,hyperglycemia,Liver,kidney,pancreas
https://ejhm.journals.ekb.eg/article_17579.html
https://ejhm.journals.ekb.eg/article_17579_a1f90599006f9e776ef0321fc60941a1.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
STRUCTURAL AND HISTOCHEMICAL CHANGES IN THE LIVER OF FEMALE RATS UNDER THE EFFECT OF INJECTABLE CONTRACEPTIVE
323
334
EN
Ashraf M.
Moustafa
Department of Histology, Faculty of Medicine Al-Azhar University
10.21608/ejhm.2009.17674
<strong>Background: </strong>Safe and effective method for contraception is still under continuous search. Injectable contraception is an attractive method and considers to be a suitable alternative for oral tablets. The use of the Medroxyprogesterone acetate (MPA) is a promising way for contraception due to its long mode of action and of minimal risk. So this study was planned to evaluate the structural and histochemical changes induced by (MPA) in the liver of adult female rats as well as testing the degree of reversibility of the changes that may develop after the arrest of its use.
<strong>Material and methods: </strong>Thirty adult female Albino Rats were used and divided into 3 groups: The first group was considered as a control group. The second group was injected intramuscularly with MPA 4 times with a dose of 2.7 mg/rat every three oestrus cycle. Liver samples were taken one day after the arrest of the last injection. The third group was treated as group two but liver samples were taken 30 days after the arrest of the last injection. Indian ink injection was done in the abdominal aorta for studying the distribution of the blood vessels in the liver. Paraffin sections were prepared and stained with Heamatoxylin and eosin and by PAS stain for structural changes and evaluating the amount of glycogen contents. Frozen sections were prepared for histochemical staining of both acid phosphatase and succinic dehydrogenase enzymes.
<strong>Results: </strong>The obtained results showed that the use of MPA causes marked vascular congestion in the hepatic vessels and it was of statistically significant when compared with that of the control. Such change was greatly improved after 30 days of the arrest of the injection.
Cellular hepatic changes were in the form of cellular hypertrophy and pale cytoplasmic staining. The cellular arrangement in the liver lobules was not altered.
Changes in the glycogen content showed marked increase in the content of its deposition and after the arrest of the injection it returns back to its normal values. Histochemically it was observed no changes in the enzymatic contents in the liver cells for both acid phosphatase or succinic dehydrogenase enzymes especially when compared with the control date.
<strong>Conclusions: </strong>It was concluded from this study that there were reversible structural and histochemical changes in the rat liver under the use of the MPA, So it is concluded that the use of MPA could considered as a safe contraceptive method. This study advise the continuous check up on the liver function during the use of such method.
MPA – Contraception,Liver – Histochemistry- Injection
https://ejhm.journals.ekb.eg/article_17674.html
https://ejhm.journals.ekb.eg/article_17674_158cd82ccad4cae47319581244f9faa9.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Whey Protein, -Lactalbumin and -Lactoglobulin in Sprague Dawley Rat
335
346
EN
Somaia A.
Nada
Pharmacology Department, National Research Centre, Dokki, Cairo, Egypt
10.21608/ejhm.2009.17583
<span>Background: </span><span>Whey is a by-product of cheese production; it is one of the components which separate from milk after curdling, when rennet or an edible acidic substance is added. Whey protein (WP) is typically a mixture of beta-lactoglobulin (</span><span></span><span>-lg) (~65%), alpha-lactalbumin (</span><span></span><span>-la) (~25%), and serum albumin (~8%), which are soluble in their native culture forms and it has the highest biological value of any known protein. </span>
<span>Materials and Methods: </span><span>Comparative studies were performed to assess the efficacy of WP, </span><span></span><span>-la and </span><span></span><span>-lg (100, 200 and 300 mg/Kg, Os) in tow animal models: hot plate-induced thermal pain and </span>
<span>carrageenan-induced paw inflammation and antioxidant activities in rats.<br /> </span><span>Results: </span><span>Results revealed that the higher doses of WP, </span><span></span><span>-la and </span><span></span><span>-lg caused significant analgesic effect versus paracetamol (50 mg/Kg) especially after 3 hr-post treatment (potency: 3.01, 3.21 and 3.45, respectively). Whereas after 4hr., WP and </span><span></span><span>-la (300 mg/Kg) treatments had similar analgesic effect. While, </span><span></span><span>-lg (200 and 300 mg/Kg) was the most potent in its analgesic effect when compared with the paracetamol and the other treated groups.<br /> In acute anti-inflammatory activity, it was shown that the two doses of </span><span></span><span>-lg (100 and 200 mg /kg) significantly reduced paw oedema after 30 min (potency versus indomethacine was: 1.11 and 1.13). While after 4 hr, the higher dose of </span><span></span><span>-la (300 mg/Kg) had similar effect to that induced by the two doses of </span><span></span><span>-lg (200 and 300 mg/Kg) treatment. The potency of the two doses (100 and 200 mg/Kg) of WP nearly had similar anti-inflammatory effect (time dependent effect).<br /> All treatments caused significant antioxidant activity when compared with the control group. The increase in SOD value was dose dependent manner. In which, 300 mg/Kg showed remarkable increase in SOD level with the following rank, </span><span></span><span>-la > </span><span></span><span>-lg > WP > indomethacine (5 mg/Kg) treated groups. These results indicated that </span><span></span><span>-lg produced powerful analgesic and anti-inflammatory activities than </span><span></span><span>- la and WP. As well as, </span><span></span><span>-la possess strong antioxidant activity than </span><span></span><span>-lg and WP treatments. </span><span>Conclusion: </span><span>It suggested that </span><span></span><span>-lg, </span><span></span><span>-la and WP could be used safely as natural analgesic and anti- inflammatory drug instead of NSAIDs, which have side effects when used for chronic disorders.<br /> </span><span><br /></span>
whey protein,-Lactalbumin,-Lactoglobulin,analgesic,Anti-inflammatory,SOD,rat
https://ejhm.journals.ekb.eg/article_17583.html
https://ejhm.journals.ekb.eg/article_17583_9c5695b17cf14169e6e3b98dd5dd95b4.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Treatment of Infantile hemangioma by ND YAG laser.
347
354
EN
Yasser A.
Hamed
Department of Dermatology and venereology; Faculty of Medicine Al-Azhar University
Maha M.
Sultan
Department of Dermatology and venereology; Faculty of Medicine for Girls, Al-Azhar University
M.
Abd Al-Salam
Department of Dermatology and venereology; Faculty of Medicine for Girls, Al-Azhar University
10.21608/ejhm.2009.17584
<span>Hemangiomas one of the most common type of congenital anomaly in childhood. Although many resolve spontaneously but intervenation is required when their growth could damage vital adjacent structure. It is characterized by an initial phase of rapid proliferation followed by slow involution, often leading to complete regression. Many therapeutic approaches for hemangiomas with different types of laser such as CO2 laser PDL, KTP and ND-YAG laser have been used </span><span>.</span><span>The aim of this study is to determined the efficacy of Nd YAG laser in the treatment of infantile hemangiomas. </span>
<span>PATIENTS & Methods</span><span>:This study include 18 patients aged 3 months to 2 years with cutaneous hemangiomas were treated with a Nd: YAG laser. The laser power was between 26- 30 joules with a pulse length 50 ml second. The lesion was cooled with dynamic cooling device (DCD) 30 ml second prior plus shots.The number of sessions was ranged from 4 to 12sessions with two weeks interval. </span>
<span>Results:</span><span>After 6 months of follow-up of laser treatment, excellent response was seen in 6 patients (33.3 %), very good response was seen 6 patients (33.3 %), good response was seen in 5 patients(27.77 %), and poor response was seen in 1 patient ( 5.55 %). Complications were seen in 3 patients 1 with bleeding and 2 with scar. </span>
<span>Conclusions:</span><span>Nd: YAG laser irradiation produces good cosmetic results for the treatment of cutaneous hemangiomas in Egyptian infants. </span>
<span> </span>
Hemangioma& ND YAG laser
https://ejhm.journals.ekb.eg/article_17584.html
https://ejhm.journals.ekb.eg/article_17584_03c77f3f64ffd6344281d4c007db8f91.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Role of tonsillectomy in the management of IgA nephropathy
355
363
EN
Mohamed Abd Allah
Salama
From ENT and nephrology departments
Al Azhar University
Wagdy Z.
El Badramany
From ENT and nephrology departments
Al Azhar University
10.21608/ejhm.2009.17585
<span>Background :</span><span>The tonsils represent a site of local immunity where immunoglobulin-bearing cells are capable of producing IgA. The tonsils have been considered the foci of abnormal IgA production in IgAN, thus, a relationship is suggested between the tonsillar immune response and the pathogenesis of IgAN. IgAN, then, is considered a tonsillar focal infection. </span><span>Patients and methods :</span><span>This study was done on 15 patients their ages ranged between 15 and 35 (10 males and 5 females). All patients were already diagnosed by renal biopsy-proven IgA nephropathy by the nephrologists and under medical treatment by conventional steroid. The diagnosis of IgA nephropathy was based on histologic assessment of percutaneous renal biopsy tissue. The main problem in all patients is that development of gross haematoria, deterioration of urinary findings and deterioration of the general condition of the patient after any acute attack of upper respiratory tract infection especially acute tonsillitis. Tonsillectomy was done after one month from controlling the acute infection. Postoperative follow up for all patients was done at 1</span><span>st</span><span>, 3</span><span>rd</span><span>, 6</span><span>th</span><span>, 12</span><span>th </span><span>month by clinical examination and laboratory investigations<br /> </span><span>Results :</span><span>The gross haematoria was completely stopped in all patients after tonsillectomy except two patients one of them was complicated by hypertension and the other one was complicated by nephritic syndrome. Also there was marked reduction in proteinuria, microscopic haematoria, marked reduction in the serum IgA concentration, urinary abnormalities disappeared and also improvement of renal function for the patients with serum creatinin less than 2mg/dl while in the two patients with serum creatinin more than 2mg/dL there was no much improvement after tonsillectomy with more deterioration of renal function of both patients with the development of chronic renal failure in the patient with nephritic syndrome 9 month postoperative<br /> </span><span>Conclusion :</span><span>Tonsillectomy is effective in improving renal function ,urinary symptoms, gross haematoria and decreasing the level of IgA in patients with IgAN if it is done in mild to moderate cases with serum creatinin less than 2mg/dL while has no much efficacy on moderate to severe cases with serum creatinin more than 2mg/dL or complicated cases. </span>
<span> </span>
IgA nephropathy,Tonsillectomy,immunoglobulins,hematuria. Aim of the work: to evaluate the role of tonsillectomy on renal functional decline in immunoglobulin A (IgA) nephropathy
https://ejhm.journals.ekb.eg/article_17585.html
https://ejhm.journals.ekb.eg/article_17585_94c376e5ea90cc6f4a5106c7028b8e30.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
35
1
2009
04
01
Comparative Study on the Effects of Phenyl Boron and Boric Acid on the Development and Gene Expression (Connexin X43 and E-Cadherin) of Pre- implantationBovine Embryos
364
377
EN
Asmaa M
Kandil
Department of pharmacology National Organization for Drug Control and Research.
Rings
F
Institute of Animal Science, Animal Breeding and Husbandry group Bonn University, Germany.
Tesfaye
D
Institute of Animal Science, Animal Breeding and Husbandry group Bonn University, Germany.
Hölker
M
Institute of Animal Science, Animal Breeding and Husbandry group Bonn University, Germany.
Schellander
K
Institute of Animal Science, Animal Breeding and Husbandry group Bonn University, Germany.
10.21608/ejhm.2009.17586
<span>The different actions of Boron (as Phenyl boron (PB) or Boric acid (BA)) on the growth of pre- implantation embryos and their (Connexin X43(CX43) and E-Cadherin) gene expression was investigated. In the first and two experiments, phenyl boron or boric acid was added as 0, 20 and 250 μM/L in embryo culture medium at 18-20 h after in-vitro fertilization (IVF). The percentage of development to blastocyst stage was assessed from day 7 to day 9 post treatment. The experiment was repeated two times using 50 fertilized zygotes /treatment. </span>
<span>The total of two of 10 blastocysts pools from each treatment group was used for mRNA isolation for quantification of Cx43 and E-cadherin gene mRNA, in the embryos of each treatment group was assessed by real time quantitative PCR.<br /> The results indicated that the rate of development to blastocyst is higher in blastocysts group treated with PB than that of BA. The highest development rate was at the 20μM/L PB and the lowest was at the 20μM/L BA treatment. The development of zygotes treated with 250μM/L BA was arressted at 4cell stage then they degenerated. </span>
<span>Relative expression levels of CX 43 were very high at doses of 250μM/L PB and 20 μM/L BA while at the same doses the relative expression levels of E-cadherin were very low. </span>
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