eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
1
27
10.21608/ejhm.2002.18817
18817
Original Article
Analytical and microscopical studies on the protective effect of ascorbic acid (vitamin C) and beta-carotene against the toxicity induced by fenitrothion on the liver of female albino rats
Ekram F. Hashim
1
Kadry Weshahy
2
Department of Plant Protection, Faculty of Agriculture, Cairo University, Fayoum, Egypt .
Department of Plant Protection, Faculty of Agriculture, Ain Shams University, Cairo, Egypt
The organophosphate insecticide feneitrothion is a contact insecticide and selective acaricide. It is used as a fly, mosquito and cockroach, residual contact spray for farms and public health programs.
The objectives of the present study were to evaluate the toxicity of fenitrothion on the female rate and the possible protective effects of ascorbic acid (vitamine C) and beta–carotene as antioxidant agents against the toxicity induced by fenitrothion. Sixty of adult female albino rats were randomly assigned to six equal groups including control group and groups treat – !" successive days.
Ingestion of fenitrtothion caused a significant increase in ALT (alanine transferase), AST (aspartate transferase), and AP (alkaline phosphatase). It decreased signifiantly GL (glucose) level, AchE (acetyle cholinesterase) and GSH (glutathion reductase) activities, while, it had insignificant effects on TB (total bilirubine) and a slight decrease in TP (total protein). The histological study of female rat liver tissues by Hx & Eosin,P.A.S, and Methyl Green Pyronine revealed that, fenitrothion showed vascular and degenrative changes in the hepatic cells, Also, it caused a significant decrease in glycogen contents and depletion in of nucleic acids in hepatic cells.
Treatments with ascorbic acid and beta–carotene plus fenitrothion hasn’t been caused any significant changes in all parameters in serum of female rats. Treatment with ascorbic acid plus fenitrothion resulted a significant improvement in all parameters tested regarding to the histological study, while, beta-carotene plus fenitrothion showed the same improvement except in glycogen content in hepatic cells .
https://ejhm.journals.ekb.eg/article_18817_d8e3effe438e86afde460ca7965fbc75.pdf
Fenitrothion – Toxicity – ALT – AST – GL – AChE – Rats – Histological – beta – carotene – Ascorbic acid
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
28
40
10.21608/ejhm.2002.18818
18818
Original Article
Histopathological and Biochemical Evaluation of the Pulmonary Toxicity of Cadmium Chloride and thiocarbamate
Somaya Y.M Hamoudah
1
Samia I. El Naggar
2
Haleem H.H
3
Department of Forensic Medicine and Toxicology, Faculty of Medicine (for Girls) Al AL Azhar University
Department of Pathology, Cairo University
Department of Biochemistry, Animal Health Research Institute Dokki
The aim of the present work is to study the acute pulmonary toxicity of cadmium chloride (CdCl) and diethyldithiocarbamate (DDTC) each separately and in "# $ %& '(( ) "%& '**+(), - # . # $ /! .0 . cadmium content in the blood and lung were measured by atomic absorption spectrophotometer. It was found that the blood cadmium concentration significantly '12!),. . "
However, with combined treatment the cadmium level in the lung showed significant
'1 2 !) / 0 , # ! Histopathological examination of the lung showed inflammatory infiltrate of alveolar septa specially around blood vessels in DDTC treated animals. While that were exposed to CdCl and to combined (CdCl + DDTC) showed interstitial fibrosis and chronic inflammation. These changes were more severe and serious with combined exposure. Moreover the electr " 0" ! of combined exposure showed damage of type I pneumocytes, hyperplasia of type II pneumocytes with loss of microvilli. While the interstitial tissue revealed collagen bundle and chronic inflammatory cells.
https://ejhm.journals.ekb.eg/article_18818_6a83012b10f9630da95d8d192655ea0b.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
41
52
10.21608/ejhm.2002.18819
18819
Original Article
Sensorineural Hearing Affection In Sickle Cell Disease Patients With Chronic Renal Failure Under Dialysis
Saeed Abdelwhab Saeed
1
Magdy M El Sharkawy
2
Fedaey M. Abbass
3
M N M R Farahat
4
Waleed F Ezzat
5
Lecturer of internal med & nephrology Ain-Shams university
Lecturer of internal med & nephrology Ain-Shams university
Fellow of nepnrology , Ahamed Maher Teaching Hospital
assistant professor Of internal med &immunology Al-Azhar university
lecturer of E.N.T. Ain shams university.
Objective: to study the problem of hearing loss in patients of chronic renal failure on regular haemodialysis and The factors which affect it. And to study the effect of sickle cell disease on hearing loss. we studied hearing loss in dialysis patients, sickle cell disease patients and patients of sickle cell disease with chronic renal failure under dialysis compared to normal control subjects.
Design: ! " " include sickle cell disease patients with chronic renal fa " #$ % & '" include (# # " #$ % & '" (# ) & ' " include the normal *+ & *+ '
All groups are subjected to full history, thorough clinical examination including neurological and ENT examination, investigations includes Hb, s. creatinine, s.albumen, s.calcium and calculation of kt/v for dialysis patients. Full audiological assessment, using # ,-GSI audiometer was done for all groups with special concentration at frequency of - .
Results: hearing loss was found in patients with chronic renal failure more than normal control. Patient with sickle cell disease have hearing disorders significantly higher than $ /% - . % 0 (## ) cell disease have significantly.
Marked degree of SNHL than those with SCD only. Hearing loss in patients with
12 (# * 3 &4!4! ' # " # "
patients with chronic renal failure with or without SCD correlate with duration of dialysis , presence of peripheral neuropathy, s. calcium level, efficiency of dialysis marked by kt/v.
Conclusion and recommendation: hearing disorder is common in patients with chronic renal failure under regular haemodialysis and it increase with duration of dialysis it should be suspected if there is Peripheral neuropathy. It can be reduced with efficient dialysis, correction of anemia, adjustment of calcium level. Patients with SCD suffer also some degree of hearing loss especially at higher frequency and this degree of hearing loss
https://ejhm.journals.ekb.eg/article_18819_4f141efa00a56d7082ab69c615ed4ae5.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
53
57
10.21608/ejhm.2002.18821
18821
Original Article
Toxicity of Biosurfactants and Synthetic Surfactants on Marine Organisms
Eman I. Siam
1
Assistant Professor in Marine Environmental Protection Programme Arab Academy for Science and Technology and Maritime Transport
This paper presents results of toxicity testing series, in which four synthetic surfactants, two commercial oil dispersants, and six bio surfactants have been examined.
The test systems were bacterial growth inhibition, microalgae growth inhibition, and microflagellate growth inhibition and biodegradation rate. The multiplication of bacteria was stimulated by surfactants, whilst that of microflagellates and microalgae was inhibited. This may be due to the metabolic usage of surfactants, especially biosurfactants by the bacteria. No toxicity could be detected with the glucose lipid GL, produced by the marine bacterium Alcaligenes sp. MMI. Most biosurfactants were degraded faster than synthetic dispersants.
https://ejhm.journals.ekb.eg/article_18821_80d0667484084c62351ba699c6ea6fb9.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
58
64
10.21608/ejhm.2002.18822
18822
Original Article
Oil Pollution hazards from reception facilities On Sidi Krier Coast-Alexandria
E.E Siam
1
M.M .Rfaat
2
Marine environmental protection program Arab Academy for science and Technology and Maritime Transport
Marine environmental protection program Arab Academy for science and Technology and Maritime Transport
Increased world demand on energy is accompanied by an increase on oil production and transport. The transport of a huge amount of oil from production field to consumption countries caused series problems to the marine environment. The actual study is focused on the oil pollution in the Egyptian northern coast waters. Water samples were taken and analyzed and the average dispersed oil concentration in ppm is determined. The oil industry and specially the reception facilities on board and on land are responsible for this pollution. The study details the reasons of the accumulated oil pollution and gives recommendations to reduce the marine environmental damage.
https://ejhm.journals.ekb.eg/article_18822_c94a7f0bf8f39c611f3da021d61b376f.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
65
75
10.21608/ejhm.2002.18823
18823
Original Article
Comparative study of either sufentanil or morphine added to a mixture of lignocaine and bupivacaine versus a mixture of lignocaine and bupivacaine alone in brachial plexus block
Dr Mervat M. El Mously
1
Hossam M. Kandeel
2
Anaesthesia & ICU
Orthopedic department
This study evaluates the peripheral opioid analgesia by comparing the effects from the addition of two types of opioids, morphine or sufentanil combined with a mixture
mixture of lignocaine, bupivacaine and adrenaline alone for patients underwent elective surgery of the forearm and hand under axillary brachial plexus block.
! " # $l (c) morphine (m) and sufentanil (s) groups. We evaluated onset of sensory block than postoperative mean arterial blood pressure (M.A.B.P), heart rate (HR), pain severity (V.A.S), time of first request of analgesia (T.F.R.A) and adverse effects. Our results showed that there were no significant differences on the onset of sensory block between (c) ,(m) & (s) groups. As regards the M.A.B.P and HR, there were significant increase in (c) group % &%&%- & nt increase in (m) group %&%&%-' & %& %&% & % – & (! ) times. After that (iv) morphine were given to abolish the postoperative pain untile the end of the study. Concerning the postoperative pain severity, the results showed that both (m) and (s) groups had significant increase of analgesia as it showed lowest pain scores compared to (c) group, and in (s) group compared to (m) group, using visual analogue scale (V.A.S).
Time of first request of analgesia was delayed markedly in (s) group than (m) group and eventually (c) group. The adverse effects were greater with (m) group compared to (c) and (s) group while it was similar between (c) & (s) group.
https://ejhm.journals.ekb.eg/article_18823_d8b60edf75b63a69e1316b2019ed3424.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
76
86
10.21608/ejhm.2002.18827
18827
Original Article
Sildenafil Citrate ( Viagra) effect on the pattern of controlled hypotension induced by sodium nitroprusside or nitroglycerin
Mona M. Radwan
1
Nemat El Baz Mohamed
2
Department of Pharmacology, Faculty of Medicine for Girls Al-Azhar University, Cairo
Department of Pharmacology, Faculty of Medicine for Girls Al-Azhar University, Cairo
Oral sildenafil Citrate (viagra) is an effective treatment for erectile dysfunction
(ED) . There are reports of serious hypotension when sildenafil citrate is given to patients taking certain vasodilators . This study was designed to assess the effects of sildenafil citrate (viagra) therapy on the dose, efficacy and safty of I.V. infusion of nitrovasodilators; sodium nitroprusside or nitroglycerin, to induce controlled "delibrate"
- !g/kg/min) or nitroglycerin "#!$!%&&' ' ( ( (&& (&&% &)*!$ & &&( variables; mean arterial blood pressure "MAP" and "ECG" pattern, were monitored.
In control groups it was found that, ( SNP) infusion achieved a rapid induction of controlled hypotension accompanied by reflex hypertension after drug infusion discontinuation. However, (NTG) infusion failed to decrease the (MAP) to the target level, and upon discontinuation of its infusion, return of arterial blood pressure to control values, was moderately slower. Comparison between the effect of the two drugs revealed a significant difference in mean arterial blood pressure after infusion.
Treatment with sildenafil citrate (viagra) , augmented the (MAP) reduction caused by (SNP), and improved the lack of potency of (NTG) induced hypotension . Comparison between the effect of the two drugs revealed a significant difference during drug infusion, and after drug infusion discontinuation. Doses of (SNP) or (NTG) required to induce delibrate hypotension in groups treated with sildenafil were decreased when compared to that in control groups.
Sodium nitroprusside (SNP) infusion induced increase in the mean heart rate (HR) without ECG changes in control or treated groups. Sildenafil citrate treatment increased significantly the initial HR in comparison to control group. In contrast, nitroglycerin (NTG) infusion, did not change significantly the (HR) in control group. However, in sildenafil citrate treated group, (NTG) infusion induced significant increase in the HR throughout the study , and there was also changes in PR QRS, and QT interval in one case.
https://ejhm.journals.ekb.eg/article_18827_e516ea006e1e6a8366b25ea7b8a7cad3.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
87
99
10.21608/ejhm.2002.18833
18833
Original Article
Bone mineral density and markers of bone turnover in patients with renal transplantation and regular hemodialysis
Samir M. Ibrahim
1
Khalid H Abdel-Mageed
2
Magdi M El-Sharkawy
3
Abdul-Zaher M. Khattab
4
Lecturer of Internal Medicine, Ain-Shams University, Cairo,
Lecturer of Internal Medicine, Ain-Shams University, Cairo,
Lecturer of Internal Medicine, Ain-Shams University, Cairo,
Lecturer of Pathology, Zagazig University, Zagazig
Background: Decreased bone mineral density (BMD) is a known complication for the uremic state antedating dialysis / renal transplantation (RTx). The issue of stabilized versus continued decrease of BMD especially on long-term basis, continues to be unresolved. Patients and Methods: ! "#" hemodialysis (HD-#" $ % " &'( )&'(-group) had been evaluated for metabolic bone changes by calcium homeostasis parameters (serum calcium, phosphorus, alkaline phosphatase “ALP” and vitamin D “calcitriol”), markers of bone formation (bone alkaline phosphatase “BAP”, osteocalcin “OC”, N-terminal propeptide of collagen type I “PINP”), bone resorption markers (pyridoline “PYL” and deoxypyridoline “DPYL”), and intact parathyroid hormone (iPTH). Also, BMD had been assessed by dual energy x-ray absorptiometry (DEXA) twice, at inclusion time and * ! " " Results: comparing both groups regarding calcium homeostasis, markers of bone turnover and iPTH showed non significant difference. However, there was a significant drop of BMD (as evidenced by T-score) at follow up in the HD group, compared to stabilization of T-score for the RTx-group. Furthermore, annual T-score change was significantly more in HD-group, compared to RTx-group. Results also showed that, the best marker correlating with T-score annual changes and iPTH to be PINP. Irrespective of normal calcium homeostasis parameters, low BMD is a prevalent disorder among patients on regular HD and renal transplants.Conclusion: Follow up for *!" % +, - ." % " " ""! to continued bone loss in patients on regular HD. This could raise recommendation for calcium and calcitriol supplementation, especially in the predialysis period, early post transplantation period, and continued guided replacement for those on maintenance HD. Serum PINP showed best correlations with BMD changes and iPTH and could be considered a reliable marker reflecting bone formation in those patients.
https://ejhm.journals.ekb.eg/article_18833_6886e5f3a9b2f38992dbda66785f3138.pdf
hemodialysis, renal transplantation, markers of bone formation
bone alkaline phosphatase (BAP), osteocalcin (OC), N-terminal propeptide of collagen type I (PINP), markers of bone resorption
pyridoline (PYL), deoxypyridoline (DPYL), intact parathyroid hormone (iPTH), dual energy x-ray absorptiometry (DEXA), bone mineral density (BMD)
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
100
117
10.21608/ejhm.2002.18834
18834
Original Article
Effect of Echis carinatus snake venom and its purified fractions F and F on the evolution of Ehrlich ascites tumor (EAT) cells
Nabil A. Soliman
1
Department of Zoology, Faculty of Science, Zagazig University, Egypt.
The present study was undertaken to investigate the effects of Echis carinatus crude venom and some of its isolated toxic fractions on Ehrlich ascites tumor (EAT) cells transplanted into the peritoneal cavity of the white female mice as an experimental model of fast growing tumor. The fractionation of the crude venom by gel filtration on sephadex G-% &', F, F and F) while, the refractionation of these fractions by ion exchange chromatography using diethylamino ethyl cellulose (DEAE-cellulose) gave nine subfractions (F(, F), F(, F), F*, F( F), F( and F)).All these separated subfractions were pure when tested by a third chromatographic step using SDS-PAGE and scanned with densitometer scan. Some in vitro biological properties of the crude venom and its isolated fractions were studied. It was found that F showed the highest value of protein content, followed by F and F(. On the other hand, it was found that no interrelationship between phospholipase enzyme activity (PLA) and the protein contents of the crude venom and its isolated fractions. Toxicity studies were conducted on adult female Swiss albino mice to determine the approximate acute median lethal dose (LD%) of the crude venom and its purified fractions. LD% of crude venom, F and F + , - .% % /g/g b.w. In addition, F and F were non-lethal, while after ion exchange chromatography, the only toxic fraction was F( (LD% 0 #% /g/g b.w.). The inhibitory effect of crude venom, F and F( on tumor growth was studied by treatment of EAT bearing mice with two intraperitoneul injections of the sublethal & 1 23%) of crude venom and its purified fractions F and F(. The + , 123% of the crude venom, F and F( was confirmed by a remarkable decrease of the viable tumor cells. This was accompanied by a significant increase in the number of dead cells, and increased percentage of survivals. On the other hand, the animals inoculated by EAT cells showed a significant increase in polymorphonuclear (PMN) and mononuclear (MN) leukocyte cells influx into the peritoneal fluid.
It could be concluded that Echis carinatus crude venom and its isolated toxic fractions F and F( showed a significant antitumor activity against EAT cells transplanted in the intraperitoneal cavity of white female albino mice.
https://ejhm.journals.ekb.eg/article_18834_49ebecba8fd1cb04006299b3b2d0b0a8.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
118
125
10.21608/ejhm.2002.18844
18844
Original Article
Principles of surgical management of adult cavus foot
Hossam Kandil
1
Department of Peadiatric Orthopedic Surgery. National Institute Neuromotor System and Rehabilitation
Back ground: Cavusfoot is a complex deformity with an abnormally high arch. It is the result of the problem, and is itself the problem. It needs complete evaluation, classification, and management. The aim of this study to evaluate the new advances in the surgical treatment of adult idiopathic cavus foot.
Material and Method: Twenty nine patients with thirty eight idiopathic cavus feet were
& ' (&
groups:- group A received surgical management including soft tissue release and anterior tarsal wedge osteotomy, group B received surgical management including soft tissue release and triple arthrodesis.
Results: The assessment of the results showed that there were significant improvement in all parameters in both groups and satisfactory results were considered obtained in
' )*+
Conclusion: Cavus foot is not alike. Surgical management must be individualized based on the age of patient, flexibility or rigidity of the deformity. I believe that correction of the deformities begins with soft tissue release. The anterior tarsal osteotomy is the best choice for cavus foot with correctable heel in young adult, and triple arthrodesis should be reserved as a salvage procedure for severe , rigid, combined deformity in older patients.
https://ejhm.journals.ekb.eg/article_18844_d2ba70859099ca75dfa1f38f3e0f8535.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
126
140
10.21608/ejhm.2002.18845
18845
Original Article
Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat.
Sohair A. Moustafa
1
Department of Zoology, Faculty of Science, Ismailia, Egypt
The impact of age on microsomal function, manifested by its ability to convert thyroid hormone thyroxine (T ) to triiodothyronine (T&), was investigated using four age '& ( ) -months). The data show impaired microsomal function with advancing age represented by a significant decrease in serum levels of T& and T&/T ratio. There was a decline in the liver glutathione (GSH), total proteins and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma- glutamyl transpeptidase (*GT). There was an-age associated increase in liver content of the lipid peroxidation products, thiobarituric acid (TBA)-reactants and the serum total protein.
++ , - . '(+ - / ' + -old) +0- 1-) mg/kg CdCl2their controls were injected with distilled water. A higher susceptibility of senile rats to cadmium toxicity was manifested as a significantly higher decrease in their serum T& level and T&/T ratio than adult compared to control. A reduction in the adaptive response of senile animals was manifested by a less increase in hepatic GSH in senile than adult as compared to control. The level of hepatic TBA-reactants was significantly higher in treated than in control group. The increase was more pronounced in the senile group. A marked hepatic cellular damage indicated by an increase in the serum levels of the AST and ALT was more pronounced in senile compared with adult rats. Treatment resulted in a decrease in the serum *GT and liver triglycerides (TG). The decrease in both parameters was more evident in senile as compared to adult group.
https://ejhm.journals.ekb.eg/article_18845_c84baede27cd0b38ae5b4469a59a2ec1.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
141
150
10.21608/ejhm.2002.18846
18846
Original Article
A Study on the bacterial flora and its significance in the housefly, Musca domestical L. (Diptera : Muscidae)
Mostafa I. Hassan
1
Zaineb M. El-Basheer
2
Eman M. Rashad
3
Marwa M. Abo-El-Maaty
4
Zoology Department, Faculty of Science, Al-Azhar University, Cairo
Zoology Department, Faculty of Science, Zagazig University
Zoology Department, Faculty of Science, Zagazig University
Zoology Department, Faculty of Science, Zagazig University
The microbial flora associated with the housefly, Musca domestica were isolated and their influence on some biological parameters of the fly was studied. The microbial flora isolation was carried out by using different selective and non-selective media. The examination of the housefly gut revealed a heavy and diverse microbial flora, these were : Enteric bacteria (Eschericia coli, Salmonella sp., Shigella sp., Pseudomonuas sp., Klebsiella sp., Proteus sp., Serratia sp.); Cocci form bacteria (Haemoltic Staphylococci and Streptococci, non-haemolytic Staphylococci and Streptococci) and Bacillus sp. Actinomycetec, yeasts and filamentous fungi were isolated only from external surface of the fly. Aposymbiotic (the gut-bacterial free) flies were obtained by feeding female flies on norofloxacine antibiotic. Hatchability, larval and pupal mortality, pupation and adult emergence were affected by elimination of bacteria from the fly gut. It was concluded that gut bacteria of the housefly are not pathogenic but their association might be mutual or even symbiotic.
https://ejhm.journals.ekb.eg/article_18846_ec26f913e79aff0bd0864aaf66058641.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
151
167
10.21608/ejhm.2002.18848
18848
Original Article
Protective effect of ginseng against toxic effect of ochratoxin (OA) in kidney of male rats
Fatma A. Morsy
1
Basic Meidcal Sciences Department, Pathology Researches, National Research Center
' ( ) * % * ( * + , * - * . /0'1 + !% (23 / /!45!1 & % *3 + * * / ! (231! (in before OA injection following the same previous schedule of injections. The remaining groups were injected with ginseng only. Paraffin sections were used for histopathological study. For histochemical investigations, sections were stained to demonstrate the glycogen, DNA, protein and alkaline phosphatase activity. OA showed sever histopathological effects on kidney demonstrated as pyknosis in some tubules and vacuolar degeneration in tubular epithelial cells. Also cell debris and hyalin casts were present in lumen of tubules. The histochemical results showed a decrease in DNA, protein content and negative reaction for glycogen and alkaline phsophatase activity. The ginseng was found to reduce the deleterious effect of OA.
https://ejhm.journals.ekb.eg/article_18848_507b0c0cc7e699b0c1afad3277066d18.pdf
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
168
176
10.21608/ejhm.2002.18849
18849
Original Article
Evaluation Of Transforming Growth Factor (Tgf- ) And Epidermal Growth Factor Receptor (Egfr) Expression In Oral Squamous Cell Carcinoma
Effat A. Abbas
1
Wafaa E. Abdel-Aal
2
Aml A. Samy
3
Basic Medical Sciences Department
Medical Division, National
Research Center
Objective: The present study aimed to investigate the pattern of expression of transforming growth factor & (TGF-&) and epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma (OSCC) and to correlate their expression with tumor grading.Conclusion: This study showed that OSCC express both EGFR and TGF-& and their expression indicated that these markers may have a potential diagnostic value in histologic examination. In addition their increased expression in high tumour grades suggest that they may be used as indicators of tumor aggressiveness.
https://ejhm.journals.ekb.eg/article_18849_c0c36706a78ca8c1e00017d605974013.pdf
Oral squamous cell carcinoma
Epidermal growth factor receptor
transforming growth factor-& and immunohistochemistry
eng
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
2002-04-01
7
1
177
199
10.21608/ejhm.2002.18850
18850
Original Article
Histopathological And Biological Studies On The Role Of Soybean And Broad Bean Against Radiation Induce Damage In Rat Kidney
Hanaa Fathy Waer
1
Abdel El – Rahman Mohamed Attia
2
Hala Abdel Rahman Hassan
3
Biology Department, Atomic Energy Authority National Center for Radiation Research and Technology
National Food Science Dept Faculty of Home Economics, Helwan University
National Food Science Dept Faculty of Home Economics, Helwan University
Most of the physiological and histological activities in the animal body are disturbed after exposure to ionizing radiation. These disturbances are either due to direct harmful effect of radiation on the biological systems or to the indirect effect of free radicals formed in the body after irradiation. There is growing evidence that the type of food plays an important role in the prevention of chronic diseases. The biological disturbance due to ionizing radiation makes search for ways of protecting living organisms essential for controlling the radiation hazards. Much of the world population relies on legumes, as a stable food. Legumes can affectively protect cells and tissues against damage. Our present study was conducted to investigate the hazardous effects of single dose !" # $ %# & f the possible protective effect of feeding beans (broad beans and soybeans) against radiation exposure. Histopathological, and biological changes of kidney function in irradiated, and bean fed animals were carried out. Animals were weighted and daily food intake was determined. The result obtained revealed that soybean is an extremely rich source of protein and fat as compared to faba bean. Radiations cause a reduction in food intake and weight gain. It causes great changes in the kidney glomeruli and collecting tubules. The recovery of the cells depend on the type of feeding so, feeding soybean gives a significant radiation protection and decreases the extent of changes induced by radiation
https://ejhm.journals.ekb.eg/article_18850_4c133fb8e53ca72a036df9ced47b5f45.pdf
Male rats- Radiation- legumes
soybean- broad bean – kidney- histology- pathology