@article { author = {Abdallah, Inas Z.A. and Khattab, Hala A.H.}, title = {Protective Role of Lycopene Against Diethylnitrosamine Induced Experimental Hepatocarcinogenesis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {1-13}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18171}, abstract = {Lycopene was considered as a major carotenoid in the human diet for only the last few centuries. Recently lycopene has been found to possess chemoprotective effect against gastrointestinal tract, urinary bladder, prostate and breast cancers. In the present study, the protective effect of lycopene, the natural extract from tomato pomace against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) formation in rats was investigated. Four groups of male albino rats at the age of 6 weeks were studied: 1) control (C), 2) DEN, i.p. injected 5 times with doses of 200 mg/kg b.w., one dose every two days. 3) Lycopene, orally given 0.12 mg/rat/day. 4) Lycopene + DEN, the treatment with lycopene started 7 days before DEN injection and continued till the end of the experimental period. Rats in group 2 and 4 were treated with Phenobarbital (PB) at a dose of 500 ppm in the drinking water as a tumor promoter. PB treatment started with the first injection of DEN and continued till the end of the experimental period. The results indicated that DEN caused HCC nodules as evidenced by a remarkable significant increase in α-L-fucosidase and metalloproteinases (MMPs) enzyme activity in both serum and cytosol. Increased activity of these enzymes is a marker for both preneoplastic and carcinoma lesions. Administration of lycopene prior to DEN injection protected rats from DEN-induced HCC as evidenced by a significant descent in α-L-fucosidase and MMPs enzymes activity in both serum and cytosol. The histological investigation of liver tissue confirmed these results. DEN group showed proliferated hyperplastic and anaplastic hepatocellular nodules surrounded with thin layer of fibroblastic cells, desmoplasia and inflammatory cells infiltrations, focal hepatic haemorrhages and necrosis. Meanwhile, lycopene + DEN group showed no histopathological changes. These results indicate that lycopene effectively inhibits DEN-induced hepatocarcinogenesis in rats. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18171.html}, eprint = {https://ejhm.journals.ekb.eg/article_18171_ecf6fb738fd710ac0b6074e94209d73a.pdf} } @article { author = {Mahmoud, Mahmoud Rabeh}, title = {Everted Intestinal Sacs As In vitro Model For Assessing Absorptivity Of L- Histidine Under The Effect Of Aspirine And Gum Acacia In Male Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {14-28}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18172}, abstract = {The purpose of this study was to characterize intestinal permeability changes over a range of physiologically relevant intestinal injury. The experiments were performed in 80 rats subdivided into four groups as aspirin (400 mg/kg b.w.), gum Acacia ( 1g./day) and aspirin with gum Acacia groups for 21 days compared with control group. Relative reabsorption of L- Histidine was greater(p<0.001) in the aspirin in 10 min of incubation compared with that of the control rats. In aspirin in combination with gum Acacia, the relative reabsorption were significantly (p<0.001) decrease in 10, 20 and 30 min. of incubation compared with that of the control rats. Moreover, the relative reabsorption of L-histidine was significantly (p<0.01) reduced by the aspirin at 45 min of time of the incubation buffer compared with that of the control. However, gum acacia treatment was increased at 10 min (p<0.01) ,30 min (p<0.01) and 45 min (p<0.001) respectively compared with that of the control rats. Relative reabsorption of L-histidine record a nonsignificant increase of aspirin at 20 min and 30 min of incubation compared with that of the control. Gum and aspirin with gum at 20min and 45min of incubation resulted an increase and decrease in relative reabsorption of L-histidine respectively compared with that of the control. Aspirin and aspirin in combination with gum acacia treatment increased body, intestinal weights and mucosal total protein significantly with percent changes ranged from 8% to 40% compared with that of the control. On the other hand, gum treatment decreased body, intestinal weights and mucosal total protein significantly with percent changes ranged from 8% to 35% compared with that of the control. These results demonstrated that L-histidine is actively taken up by a gum Acacia system in intestinal everted sac mechanism of rat with energy supplied by glucose and Na+in incubation buffer. Moreover, aspirin system had an inhibitory effect on L-histidine uptake in 45 min of incubation , indicating the saturation by L-histidine in first ten minuts of incubation. Also, these results provide evidence the uptake of L-histidine into rat intestine was not reduced at all by the treatment of aspirin. These results suggest that the uptake of L-histidine by intestinal everted sac of rat has different characteristics of aspirin with gum compared with that of the control in respect to relative reabsorption of L- histidine.  }, keywords = {everted sac,L-histidine,aspirin,Gum Arabic,relative reabsorption}, url = {https://ejhm.journals.ekb.eg/article_18172.html}, eprint = {https://ejhm.journals.ekb.eg/article_18172_96109658ac441bdf63da11d51f3e41fc.pdf} } @article { author = {Abdel-Rahman, Mervat}, title = {Effect Of Exposure To Electromagnetic Field On Tumour Growth And Some Serum Parameters In Mice Implanted With Ehrlich Tumour.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {29-38}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18173}, abstract = {Objective: To investigate the bio-effects of electromagnetic field (EMF) exposure on blood elements, blood glucose, liver and kidney functions of mice implanted with Ehrlich tumour. Methods: female BALB/c mice inoculated subcutaneously with cell suspension isolated from Ehrlich ascitis carcinomas were exoposed to sinusoidal 50 Hz, 0.2 Tm for 21 days. Results: exposure to low frequency EMF resulted in a pronounced decrease in tumour growth. The increase in total leucocytic count, liver enzymes, bilirubin, blood glucose and creatinine observed in mice with implaned tumours, was significantly reduced by low frequency EMF exposure. Conclusions: these results suggest that exposure to low frequency EMF of 50 Hz inhibits malignant growth in mice with Ehrlich tumour. It is suggested that low frequency EMF may find utility as a method in the treatment of tumours, either alone or in conjunction with chemotherapeutic agents.  }, keywords = {magnetic field,Ehrlich tumour,Mice,kidney,Liver,blood picture}, url = {https://ejhm.journals.ekb.eg/article_18173.html}, eprint = {https://ejhm.journals.ekb.eg/article_18173_cf06cab404e39416eedec35da3d56908.pdf} } @article { author = {Eissa, Omiama Soliman}, title = {Protective Effect of Vitamin C and Glutathione Against the Histopathological Changes Induced by Imidacloprid in the Liver and Testis of Japanese Quail.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {39-54}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18174}, abstract = {Pesticides are double wedged weapons. They are considered to be the heavy cost of civilization. They are widely used in our daily life. Recently their effects on male fertility have attracted attention. One of these pesticides is imidacloprid. This work was designed to investigate the histological changes in liver and testis of Japanese quail treated with imidacloprid for different periods as well as the reversibility of such changes after arrest of the treatment for recovery period. The effect of vitamin C and glutathione as a protective agent against the action of imidacloprid on liver and testis  }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18174.html}, eprint = {https://ejhm.journals.ekb.eg/article_18174_77bd44a168dd42c29c913ae28a4202fb.pdf} } @article { author = {Ebrahim, Amira Tohamey and El-Gendy, Ahkam, M. and El-Zawahry, Boshra}, title = {Antihepatotoxic potential of ginseng (Panax ginseng) in thioacetamide-induced acute hepatocellular injury in rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {55-64}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18175}, abstract = {Previous studies demonstrated the hepatotoxicity of thioacetamide (TAA) in rats. The present study is a trial to decline TAA-hepatotoxicity by using the roots of herbal medicinal plant (Panax ginseng) pre-treatment . Low dose of TAA (50-mg/kg b.wt) was chosen to induce hepatoxicity in male rats previously treated with ginseng for 10 consecutive days. The tested parameters were studied after 24, 48 and 72 hours post TAA intoxication. Fluctuatious of serum glucose were noticed in TAA intoxicated rats increased after 24 h (+ 9.31%), 48h. (+ 7.11%), followed by moderate improvement after 72 h. (+5.39%) when compared with control group. Ginseng pretreatment enhanced these changes towards the normal values. Serum and liver enzyme activities ( AST, AIT, ALP and  GT) increased in TAA intoxicated rats which peaked after 48 h, and began to decrease after 72h. Pretreatment with ginseng improved enzyme activities to some extent. Reduced glutathione (GSH) as well as antioxidant enzyme glutathione reductase (GSH-R) activity while lipid peroxidation (LPO) increased in TAA intoxicated rats and enhanced by pretreatment with ginseng. This results suggest that pretreatment with ginseng could improve the detoxifying activity of the liver rats with TAA-induced acute hepatotoxicity.  }, keywords = {Liver toxicity- Thioacetamide- Ginseng,Liver Function - Liver antioxidant - Lipid peroxidation}, url = {https://ejhm.journals.ekb.eg/article_18175.html}, eprint = {https://ejhm.journals.ekb.eg/article_18175_0f2905219592b8bc59a13f61d0479952.pdf} } @article { author = {Swelim, Hamdy Hamed}, title = {Adrenal Suppression Induced by Megestrol Acetate and the possible protective role of selenium A Histological , Histochemical and Ultrastructural Study}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {65-91}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18176}, abstract = {The anticancer drug megestrol acetate (MA) is suspected to cause adrenal insufficiency. Several clinical reports indicated that suppressed adrenal function might be possible in long term administration of MA . The present study was designed to evaluate this issue by using the histological, histochemical and ultrastructural techniques. The data obtained from the present study indicated that MA caused various cellular and subcellular damages in most of the cells of the three zones of adrenal cortex. Histochemical investigations indicated increased lipid content associated with increased storage of ascorbic acid and acid phosphatase, and all these data might reflect a state of suppressed steroidogenesis. The results also indicated that selenium might have a protective role against the cytotoxicity of megestrol acetate on adrenocortical cells. All the results were discussed and it is concluded that more followup of adrenal function should be done during the long term treatment with MA, and an additional protective supplement . }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18176.html}, eprint = {https://ejhm.journals.ekb.eg/article_18176_d92824f959f0974ca333584b530a6a07.pdf} } @article { author = {Khalil, Enas A. M.}, title = {Antidiabetic effect of an aqueous extract of Pomegranate (Punica granatum L.) peels in normal and alloxan diabetic rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {92-99}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18177}, abstract = {Hypoglycaemic drugs are either too expensive or have undesirable side effects including hematological, coma and disturbances of liver and kidney. Limiting of diabetes without any side effects is still a challenge to the medical system. This leads to exert effort to search for effective, safer and less cost antidiabetic plants. This investigation aims to evaluate the role of Punica granatum powder peels extract in its human therapeutic dose on beta cell numbers blood glucose and plasma insulin levels in normal and alloxan diabetic rats for 4-weeks of treatment. The treatment revealed that pomegranate aqueous extract significant decreased blood glucose and increased insulin levels in normal and diabetic treated rats. Pancreas showed increased number of beta cells in normal and treated diabetic rats. In conclusion pomegranate peel aqueous extract can reduce blood sugar through regeneration of ß cells. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18177.html}, eprint = {https://ejhm.journals.ekb.eg/article_18177_adb3acd8d71e48199bff2ffbb2f8c3a9.pdf} } @article { author = {Abu Zeid, Hani and Aggag, Mohamed farouk and Ismail, Walid Foad and Abdullah, Ola M.}, title = {A Study Of MR Imaging Of The Basal Ganglia And Serum Manganese Concentration In Cirrhotic Patients With Portosystemic Shunting}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {100-111}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18178}, abstract = {Manganese in normally removed by hepatobiliary route. In long term hepatic dysfunction with portosystemic shunting it accumulates in systemic circulation and may deposit in CNS particularly in the basal ganglia, resulting in permanent extrapyramidal manifestations and a unique form of parkinsonism characterized by early gait impairment, postural fine tremor, symmetric akinetic rigidity and sometimes associated with focal dystonia (Purkhard et al., 2003). In this study: 50 male cirrhotic patients, aged 28 –59 years, were selected from Internal Medicine department – Al Hussein university hospital, in addition to 20 age-matched healthy males as a control group. All subjects (patients & controls) were submitted to (1) Full clinical & laboratory examination including liver function tests and serum manganese estimation using atomic absorption technique. (2) Abdominal triphasic spiral CT scanning for evaluation of portosystemic collaterals and to assess the hepatic intensity and the splenic size (3) MR Imaging of the brain. We have concluded that: (i) The studied cirrhotic patients had a statistically higher serum manganese concentration than that of the controls. (ii) 24/50 patients (48%) showed variable degrees of basal ganglia hyperintensity on T1- weighted MR images, associated with marked elevation of serum manganese levels (five to seven fold the normal level) and advanced grades of gastroesophageal varices on triphasic spiral CT scanning (iii) 26/50 patients (52%) showed normal intensity in the basal ganglia on T1- weighted MR images with relatively Lower levels of serum manganese (two to four fold the normal level) and early grade of gastroesophageal varices on triphasic spiral CT scanning (iv) serum manganese concentration of cirrhotic patients with hyperintensity in the basal ganglia on T1 weighted MR imaging was statistically higher than that of cirrhotic patients with normal intensity – basal ganglia. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18178.html}, eprint = {https://ejhm.journals.ekb.eg/article_18178_734778bef199020249820046edce92f1.pdf} } @article { author = {Khalil, Enas A. M.}, title = {A hepatoprotective effect of an aqueous extract of pomegranate ( Punica granatum L. ) rind against acetaminop hen treated rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {112-118}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18179}, abstract = {In ancient times Egyptians regarded pomegranate fruit as a symbol of fertility due to the round shape and abundant seeds .They used it to heal many ailments. Pomegranate (El-Ruwmon ) that fruit mentioned in our holy Quran not less than three times, that paid attention for its importance. This investigation aims to evaluate the hepatoprotective activity of an aqueous rind powder extract of pomegranate (Punica granatum L.) in its human therapeutic dose against overdose acetaminophen. Pretreatment of rats with 0.43g/KgB.W.of an aqueous rind extract of Punica granatum for 3 days before intraperitoneally (i. p.) injection of 0.5gm acetaminophen significantly reduced the acute elevation of serum aspartate aminotransferase (AST),serum alanine aminotransferase , lactate dehydrogenase (LDH)and alleviated the degree of liver damage after the i.p. injection of hepatotoxin. The group treated only with 0.5gm acetaminophen displayed significant increase in serum (AST),(ALT), (LHD)and liver displayed congestion of central and hepatic portal veins, vacuolization and ballooning also a lot of pyknotic nuclei were detected with many small necrotic areas of hepatocytes. Inflammatory cells inbetween hepatocytes and around the portal tract were observed. Some fatty droplets were scattered in the hepatocytes. In conclusion aqueous extract of pomegranate peels possess a strong antioxidant capacity could ameliorate the damage occurred in liver by overdose acetaminophen }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18179.html}, eprint = {https://ejhm.journals.ekb.eg/article_18179_c5c863b938e944614fe6ec916931a29f.pdf} } @article { author = {L.R, Fatma, and R. G., Rezk}, title = {Evening Primrose Oil Attenuates Certain Radiation Induced Functional and structural Disorders in Female Rats.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {119-131}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18180}, abstract = {The aim of the present study was to evaluate the modulator role of evening primrose oil (EPO) on the radiation induced changes in certain biochemical and histological abnormalities. Female rats were exposed to 5 Gy whole body -irradiation delivered as single dose. EPO was orally administrated to rats (9 ml/100g b.wt) 7 days before irradiation exposure. Animals were sacrificed 1 day (oestrus stage), 6 days (one estrus cycle) and 12 days (two estrus cycle) after irradiation. The results obtained revealed that treatment with EPO diminished the increase in total cholesterol, urea and creatinine levels in plasma in comparison with the levels recorded in the plasma of irradiated rats. Significant amelioration of the radiation induced changes in RBC,s WBC,s count and the haemoglobin concentration, calcium level, FSH and LH hormones were also recorded in the plasma of EPO treated and irradiated rats. Histological observations of photomicrograph of kidney and ovary sections showed that irsaoiaun resulted in irradiation induced ruptured, dilated, haemorrhage glomerulei dissolution of the majority of primary follicles, and atrophy in ovary size. All these changes were obviously improved in animals supplied with EPO. It could be concluded that EPO could be useful adjunct for maintaining the integrity of biochemical functions and restoring the original histological architecture of kidney and ovary after irradiation. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18180.html}, eprint = {https://ejhm.journals.ekb.eg/article_18180_f6ff2602c38660100d90e9dbdbe164bf.pdf} } @article { author = {Khalil, Enas A. M.}, title = {Biochemical and histopathological changes in male albino rats treated with overdose of an aqueous extract of pomegranate (Punica granatum L.) pericarps}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {16}, number = {1}, pages = {132-139}, year = {2004}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2004.18181}, abstract = {Pomegranate has been cultivated since ancient times. All parts of this plant were used to treat various ailments. It mentioned for three times in the Holy Quran under the name of Rumman in Surah (Al- Anaam) verse 99 , Surah (Al-Anaam) verse 141 and Surah (Al-Rahman)verse 68. In Surah (Al-Anaam) verse 141.'' It is He who produce the gardens with trellises and without ,and dates and tilth with produce of all kinds and olives and pomegranates ,similar (in kind ) and different (in variety) :eat of their fruit in their season ,but the dues that are proper on the day that the harvest is gathered .But waste not by excess. For Allah loves not the wasters''. This investigation aims to study the effect of repeated over doses of an aqueous extract of pomegranate ( Punica granatum L .) pericarps in male albino rats for a month. Oral administration of repeated over doses ( 1.3g/k) of an aqueous extract of pomegranate ( Punica granatum L .) pericarps in male albino rats for month displayed significant increase in serum aspartate aminotransferase (AST), alanin aminotransferase (ALT),alkaline phosphatase and liver revealed congestion of central vein ,dilatation of sinusoids , vacuolization and (ALT) ballooning also a lot of pyknotic nuclei were detected with many necrotic areas of hepatocytes. Inflammatory cells were detected inbetween hepatocytes, dilatation of the portal tract and fibrosis noticed around it. Elevation of serum urea , creatinine ,dilatation and severe congestion of blood vessels , most glomeruli were congested ,dilatated, and some appeared degenerated. Diffuse extravagations of red blood cells between the degenerated renal tubules were noticed .Augmentation of serum total cholesterol , decreased serum triglycerides and formation of medial calcinosis in aorta. Reduction in serum testosterone level, some seminiferous tubules appeared normal but the others appeared affected. All things must be taken in moderation because repeated high doses of an aqueous extract ofpomegranate pericarpswillbetoxic. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18181.html}, eprint = {https://ejhm.journals.ekb.eg/article_18181_cd7e13ba854b10111c7c2120d7a5b110.pdf} }