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18 years) patients with de novo AML, recruited from National Cancer Institute, Cairo University. They were divided in to 2 groups; group 1 of APL cases (n= 35) and group 2 of AML-Non APL cases (n= 35) as a comparative group. Both groups were investigated by flow cytometry for the expression of CD11a and CD18 molecules on leukemic cells. Results: Comparison between group 1 and group 2 illustrated significant reduction in % of cells expressing CD11a (p= 0.014), CD18 (p=0.008) and % of cells co-expressing CD11a /CD18 (p=0.007) in group 1 compared to group 2. There was significant positive correlation between % of cells expressing CD18 and TLC (r=0.411, p=0.014). There was significant positive correlation between CD11a MFI and hepatomegaly (r=0.390, p=0.021) in AML-Non APL group. Regarding the output data of ROC curve for discriminative percentage of leukemic cells expressing CD11a and CD18 between APL and Non-APL groups, at cut off 78.95% and 23.5% respectively, the specificity for both was 60% and 68.6%, respectively. While sensitivity was 77.1% and 68.6%, respectively, with Area Under Curve (AUC) of 0.671 and 0.686 and p value of 0.014, and 0.008 for leukemic cells expressing CD11a and CD18, respectively. Conclusion: [1] There is significant reduction in % of cells expressing CD11a and CD18 in APL patients, but they were neither sensitive nor specific to be used as single markers in diagnosis of APL patients. [2] Positive correlation seen between the most important prognostic factor, TLC and both CD18 MFI and percentage of cells expressing CD18 could throw light on the potentiality of CD18 as a prognostic factor. [3] Significant positive correlation between CD11a MFI and hepatomegaly in Non-APL cases might suggest a role of CD11a in migration of leukemic cells.]]>
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6U/ml. Also, it can be used to discriminate between colorectal polyp and CRC patients at cut-off level of >10.6 U/mL with 75.5% sensitivity and 87.5% specificity and to differentiate between FBD and organic colonic lesions at cut-off level >3 U/ml with 81.94% sensitivity and 83.3% specificity. Conclusion: plasma M2-PK was considerably elevated in CRC patients and may be used as non-invasive biomarker for CRC. Recommendation: future researches including a large and long-term follow-up studies are recommended.]]>
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0.05). Conclusion: our findings suggested that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response.]]>
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0.001(, started to rise again in its evaluation after 4 weeks but not reaching its values before rTMS sessions. the percentage of severe cases in each scale category was dramatically decreased immediately and 2 weeks after rTMS sessions and started to rise again in its evaluation after 4 weeks but to lower percent than before rTMS sessions (70%, 100% and 60% had severe inattention, hyperactivity and impulsivity respectively before rTMS, reduced to 0%, 0%, 10% immediately and 2 weeks after rTMS but increased to (20%, 40% and 40%) after 4 weeks. no patient experienced any significant adverse effects during the study, except 3 children reported mild headache that resolved spontaneously within an hour without medication. Conclusion: this study concluded that r TMS over left dorso-lateral prefrontal cortex may be safe and effective way of providing relatively lasting relief of ADHD symptoms especially in children with severe symptoms.]]>
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