0.05 respectively ) . The mean percentage of CXCR3 expression on CD3+ T lymphocytes and MFI in AD children were 17.9 % and 2.9 respectively compared with 67.93 %and 3.3 in healthy controls (p < 0.01 and p > 0.05 respectively ). The mean of the total serum IgE in the patient group was 199.3 IU/ml compared with 62.27 IU/ml in non-atopic children (p < 0.01).
Conclusion : These results suggest that there is a relation between atopic conditions and an increase in peripheral blood T lymphocyte expressing CD38% and decrease expression of CXCR3%.The presence of high expression of CD38 in atopic patients seems to confirm the role of this molecule as an activation marker useful for evaluation of Th2 immune response . whereas CXCR3-expression on CD3+ lymphocytes decreased in AD than normal control as the chemokine receptor profile determine the migratory patterns of leukocytes . These results may suggest the dysbalance between Th1/ Th2 in AD patients .
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