Use of Noninvasive Positive Pressure Ventilation in Acute Respiratory Insufficiency after Cardiac Surgery
Mohamed Abdel Rahman
Salem
Anesthesia Department, Faculty of Medicine, Menofyia University.
author
text
article
2004
eng
Background: Non-invasive positive pressure ventilation (NIPPV) using bilevel positive airway pressure (BiPAP) ventilation is a safe and effective mean of improving gas exchange in many types of respiratory failure. The results of application of NIPPV to patients who had cardiac surgery and developed respiratory failure after extubation still to be investigated.
Aim of work: To compare the efficacy of NIPPV delivered through a face mask with the efficacy of conventional mechanical ventilation (CV) delivered through an endotracheal tube and investigates its hemodynamic effects in this group of patients.
Materials and Methods: NIPPV and CV were applied to twenty four patients in two groups who had open heart surgery and suffered from severe respiratory deterioration after tracheal extubation. Respiratory and invasive hemodynamic parameters were measured before starting ventilation, 1, 6, 12 hours, and before and after weaning of ventilation and incidence of ventilatory complications were recorded.
Results: Respiratory parameters improved significantly in patients in both groups after one hour but one patient was intubated in NIPPV group. There were no significant differences between the two groups as regards the hemodynamics and respiratory parameters. Respiratory complications and infection were not noticed in NIPPV group during the study.
Conclusion: NIPPV is considered an effective method of treating patients with acute respiratory insufficiency after cardiac surgery with minimal effects on respiratory and
hemodynamic parameters. It reduces the mechanical ventilation.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
124
131
https://ejhm.journals.ekb.eg/article_18216_f4a257d3b3a3a2d05c186fa397fb7774.pdf
dx.doi.org/10.21608/ejhm.2004.18216
Comparative analysis of the protective effect of melatonin and Cleome droserifolia extract on antioxidant status of diabetic rats
Nahla S.
El-Shenawy
Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
author
Ismail M.
Abdel-Nabi
Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
author
text
article
2004
eng
The present study was carried out to compare the antihyperglycemic effects of melatonin and extract of Cleome droserifolia separately or in combination on the antioxidant defense system of diabetic rats. Melatonin (10 mg kg-1) and C. droserifolia (0.045 g kg-1day-1) were given i.p. after induction of diabetes with alloxan (110 mg kg-1). Administration of alloxan to rats resulted hyperglycemia, hypoinsulinemia, reduced thyroid hormone levels and decreased body weight. These changes were accompanied with significant decrease in serum total protein, nitric oxide (NO), total antioxidant capacity (TAC), liver glutathione (GSH) level and catalase activity (CAT) of diabetic rats. Serum protein level of the melatonin or extract groups did not differ significantly during the period of the study as compared with the diabetic group, while it returned to the normal level in the case of combined-exposure. Melatonin increased the levels and activities of antioxidant markers including total protein, GSH, catalase and NO as compared with diabetic group. Melatonin and crude extract of C. droserifolia caused a significant decrease in liver tissue malondialdehyde (MDA) levels. Furthermore, treatment of diabetic rats with crude extract or its combination with melatonin had more potent effect on liver GSH level, insulin, T3, T4 and T3/T4 ratio than treatment with melatonin only. C. droserifolia was found to be less effective on CAT levels in liver than melatonin. TAC had positive correlation with GSH and CAT, while it had negative correlation with MDA. The present results confirmed that diabetes increased oxidative stress in liver and indicated the role of melatonin in combating the oxidative stress via its free radical-scavenging and antioxidant properties. Also, crude extract prevented any diabetic complications by reducing oxidative stress and protected rats from oxidative damage. Considering the much lower concentration of melatonin compared with extract, melatonin seems to be more potent antioxidant. Concomitant exposure to melatonin potentiates crude extract as antihyperglycemic effect on diabetic rats.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
11
25
https://ejhm.journals.ekb.eg/article_18217_cdc37d539b0f3f83d9eae9e231de45d7.pdf
dx.doi.org/10.21608/ejhm.2004.18217
Histological, Immunohistochemical and clinical study of HEPATIC immune response in CHRONIC hepatitis C
Aboushady
MA
Departments of Internal Medicine, Histology and Clinical Pathology; Faculty of Medicine, AlAzhar University
author
Algyoushy
AF
Departments of Internal Medicine, Histology and Clinical Pathology; Faculty of Medicine, AlAzhar University
author
Elbaz
TZ
Departments of Internal Medicine, Histology and Clinical Pathology; Faculty of Medicine, AlAzhar University
author
Saleh
SA
Departments of Internal Medicine, Histology and Clinical Pathology; Faculty of Medicine, AlAzhar University
author
Ewees
IE
Departments of Internal Medicine, Histology and Clinical Pathology; Faculty of Medicine, AlAzhar University
author
text
article
2004
eng
The factors that determine persistence or clearance of hepatitis C virus (HCV) infection are poorly understood. Information in this area may lead to better understanding of the immune response against HCV infection. Such understanding can support the goal of development of a broad based cellular and humoral immune response to HCV which may be important for eradication of infection.
In the present study, needle biopsy specimens from hepatitis C virus infected patients were prepared for histological, histopathological and immunohistochemical studies. Patient history, full clinical examination and biochemical investigations were recorded.
Primary and secondary lymphoid follicles were evident in ABOUT 50% of the biopsies. Because CD4(+) T- helper (T-h) lymphocytes provide help for humoral immunity, these cells were demonstrated in the liver biopsies by immunohistochemical methods. Positive fluorescence representing CD3(+)/CD4(+) T-h was vigorous in liver residing lymph follicles.
To test the possibility of T-h proliferation due to autoimmune reaction, the serum of patients was tested for the presence of antimitochondrial, antismooth muscle and antinuclear antibodies by immunohistochemical method. Analysis of the results eliminated the autoimmune response leaving the possibility of antiviral response.
Histological examination indicated bile duct injury in areas occupied by secondary follicles. This may indicate that viral core proteins, with antigenic properties that elucidate immune response, may reach the portal area, in which the follicles are formed, via the bile canaliculi to the bile duct where antigen antibody complex is phagocytosed leading to bile duct injury. Unlike the case of patients who did not show follicles in their liver biopsy, those showing secondary follicles did not show liver cirrhosis or high grade fibrosis suggesting immune protection. Moreover, the incidence of secondary follicles in females was higher than males suggesting sex-dependent immune response. The present study calls for more investigation towards the understanding of the possible immunity and vaccination against virus
C hepatitis which may lead to eradication of its infection.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
26
33
https://ejhm.journals.ekb.eg/article_18218_e0d1b6388e43f5f2d67bc687d777cfdf.pdf
dx.doi.org/10.21608/ejhm.2004.18218
Immuno-histochemical study of the expression of Bcl-2 in the Leydig's interstitial cells and primary spermatocyte cells of adult male rabbit under the effect of oral Gossypol intake
Bassem S.
Ahmed
Departments of, Histology Al-Azhar Faculty of Medicine – Assuit
author
Nasser M.
Anwar
Pathology Al-Azhar Faculty of Medicine – Cairo
author
text
article
2004
eng
Gossypol is a natural compound extracted from the seeds of some species of cotton plants (Gossypium species). Gossypol displays various drug properties, including male antifertility, anti- proliferative activity on tumor cells (leukemia, prostate, adrenal, etc.) and endometriosis.
Recently, the action of gossypol has been thought to induce apoptosis in the target cells especially male testicular tissue. The current study was planned to evaluate the effect of oral intake of gossypol on the expression of anti-apoptotic Bcl-2 gene in the interstitial cells of Leydig and primary spermatocyte cells of adult rabbit.
Thirty adult male rabbits were used, subdivided into 5 equal groups. Group1 represented control group, groups 2, 3, and 4 represented rabbits intubated with 1.05mg/day gossypol suspended in 1ml. olive oil for 3,6 and 9 weeks respectively. Group5 rabbits were subjected to gossypol oral intake in the same manner for 9weeks and were left for another 9weeks as recovery periods.
All rabbits were sacrificed after 24hrs from last dose except group5 rabbits, testes were extracted fixed in neutral buffered formol and histologically processed for 5um paraffin sections. Detection of Bcl-2 protein was done by using labeled streptavidin biotin technique with the monoclonal Bcl-2 antibody.
The evaluation of Bcl-2 expression in the interstitial cells of Leydig and primary spermatocyte cells, as an optical density, were done by the aid of image analysis system. The obtained data were statistically analyzed by using student t-test. The study showed that there was a positive Bcl-2 expression in the interstitial cells of Leydig in all study groups, and there were statistically significant increase in the Bcl-2 expression in groups 2, 3 and 4 in comparison to control rabbits values (p<0.001). The recovery group rabbits showed a statistically significant decrease in the Bcl-2 expression (p<0.001) in comparison to control rabbits values.
The primary spermatocyte cells showed a very weak Bcl-2 expression in control group rabbits and rabbits of groups 2 and 3. After 9weeks gossypol administration there was a positive Bcl-2 expression in some primary spermatocyte cells (p<0.001) and the overexpression of Bcl-2 was continued in the recovery group rabbits (p<0.001).
The study concluded that gossypol may trigger Bcl-2 expression in interstitial cells of Leydig, which started after 2weeks of oral administration and this effect is diminished after cessation of oral intake. Also there was an increase in Bcl-2 protein expression in primary spermatocyte cells after 9weeks of oral gossypol intake and that increase persisted even after cessation of gossypol. The study recommends further study about the role of gossypol on the relation between apoptosis inducing gene and apoptosis inhibiting gene in the testicular tissues.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
34
44
https://ejhm.journals.ekb.eg/article_18219_13a349c3b86c95a56406988b7aeadb44.pdf
dx.doi.org/10.21608/ejhm.2004.18219
Fetal Growth Retardation And Its Relationship To Maternal Blood Lead Levels, Antioxidants And Pregnancy Induced Hypertension
Ragab H.
EL-Yamani
Obstetric and Gynecology Dept. Faculty of Medicine, Al-Margab University, Great Socialist People’s Libyan Arab Jamahiriya
author
Ahmed E.
Karim
Biochemistry Dept., National research center, Cairo, Egypt.
author
text
article
2004
eng
Lead intoxication in human being has been documented since the second century BC and its deleterious effects continue to be a major health hazard for the population, it is demonstrated that lead exposure might decrease the defense mechanism of the cell to the oxidative stress, and therefore, elevate the reactive oxygen species (ROS) generation which enhance vascular reactivity. Since vitamin E (Vit. E) and vitamin C (Vit. C) are natural antioxidants, changes in their status may reflect alterations in free radical production rate and their concentrations are biological markers of oxidative stress. This study was conducted to determine the relationship between maternal blood lead levels and the antioxidants Vit.E and Vit.C in a step to understand the mechanism of action of lead and its possible influence on maternal blood pressure and fetal growth at the lower community exposure levels.
The study included, 42 patients with pregnancy induced hypertension (PIH) with or without proteinuria, 31 patients with fetal growth retardation (FGR) and 23 women with uncomplicated pregnancy. We demonstrated that, the maternal blood lead levels were significantly high in the PIH (30.5 ±0.978 μg/dl) and FGR groups (28.87 ±1.21 μg/dl) as compared with the uncomplicated pregnancy group (17.82 ±110μg/dl) at P≤0.00l Vit.E concentrations were significantly lower in both PIH and FGR (0.941 ±0.033 mg/dl and 0.866 ± 0.055 mg/dl respectively) when compared with normal group (2.00±0.085 mg/dl). Regarding Vit.C in the 2 studied groups there was significantly low levels in PIH group (0.772 ±0.030 mg/dl and FGR (0.847 ±0.039 mg/dl) in comparison with control group (l.23 ±0.06 mg/dl). We observed significant negative correlation between maternal blood lead levels and Vit.E in PIH and FGR group. A significant negative correlation was also observed between maternal lead levels and Vit.C in both studied groups.
We concluded that high blood lead levels in pregnancy are associated with low Vit.E , Vit.C, FGR and PIH. Such association or relationship could not be causal and more longitudinal studies are needed to confirm the link between lead, lipid peroxidation, antioxidants and pregnancy complications. This study may help in raising our consciousness of our environment and the need to protect us. The lack of effective and safe treatments for low-level intoxication has to promote environmental intervention to control different sources of lead to reduce lead burden among women and their newborns and to protect the fetus from other intrauterine toxic exposure that might be injurious.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
45
55
https://ejhm.journals.ekb.eg/article_18220_259e205d14f30df51ed464c1e4368e0a.pdf
dx.doi.org/10.21608/ejhm.2004.18220
Effect Of Haemodialysis On Intra Dialytic Calcium, Phosphorus, Magnesium, Levels In Relation To Autonomic Nervous System Activity
Mona
Hosny
Internal Medicine Departement, Ain Shams University.
author
Sahar
Shawky
Internal Medicine Departement, Ain Shams University.
author
Ahmed
Ramadan
Internal Medicine Departement, Ain Shams University.
author
Hany
Refaat
Internal Medicine Departement, Ain Shams University.
author
Walid
Bischary
Internal Medicine Departement, Ain Shams University.
author
text
article
2004
eng
Autonomic nervous system dysfunction is common in uremia and in patients under hemodialysis.
Changes in serum calcium, serum phosphorus and serum magnesuim always occur during hemodialysis. The relation between these changes and autonomic nervous system activity during hemodialysis has not been fully studied.
This study was carried out on 30 patients with chronic renal failure on regular hemo- dialysis with nearly similar age group. We measured serum calcium, serum phosphorus and serum magnesium throughout the session (at predialysis state, middialysis state: after 2 hours of the session and postdialysis: at the end of the hemodialysis Session). We have also assessed autonomic function (sympathetic by cold pressor test and parasympathetic by Valsalva maneuver test). Autonomic function tests were assessed at predialysis state, middialysis state and postdialysis state.
Calcuim level uncreased throughout the session (P<0.05), phosphorus leuel and Magnesium levels decreased , (P<0.001) and (P<0.05), throghout session .
As reguards parasympathetie dysfunetion, there was a significamt relation (P<0.05) with calcuim changes at predialytic and post dialytic states, a highly significant relation (P<0.001) with phosphorus and (P<0.05) with magnesiun, both at predialysis states.
Concerging sympathetie dysfunction, there was a significant relation (P<0.05) with calcium levels at end of session. There was a signifcant relation (P<0.05) with predialytic and postdialytic phosphorus levels .There was also significant relation (P<0.05 ) with predialytic magnesium level.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
56
67
https://ejhm.journals.ekb.eg/article_18221_2504635313f5accf4567b2dae647e708.pdf
dx.doi.org/10.21608/ejhm.2004.18221
The effects of folic acid on carbon black toxicity in mouse embryo in vivo
Roshdy,
H.M
Cell Biology Department, National Research Center Dokki, Cairo, Egypt
author
Bibars,
M.H
Cell Biology Department, National Research Center Dokki, Cairo, Egypt
author
text
article
2004
eng
The wide commercial use of carbon black oil (CBO) to produce asphalt and other commercial product has resulted in numerous environmental problems and harmful effects on human health especially during the pregnancy. This study, examining the effect of maternal low and high dietary folate intake and to protect the pregnant women from the developmental toxicity of CBO. Virgin females CD—1 mice were assigned to diets containing either low 500 or 1300 high (control) nmol folic acid/kg for 6 weeks prior to mating and thought out breeding and gestation. From gestation day (GD 6 to 18) females were given by gavage corn oil or CBO at 500 mg/kg body weight, once daily. On CD 18, mice were weight and killed and the liver removed and weighed. Implantation sites, live and dead fetuses, and resorptions were counted, fetuses were weighed individually and examined for external malformations. The low dietary FA treatment alone and with CBO treatment resulted in low maternal liver as well as low fetal liver folate concentrations relative to the high FA dietary groups. Low FA treatment alone resulted in malformed embryos; there were no embryos affected with malformed in the adequate FA-control group. Low folic acid-CBO treatment resulted in a further increase in the malformed embryos. The percent of malformed embryos in high folic acid-CBO treatment was very low compared to the low folic acid-CBO group. The frequency of chromosomal aberrations in maternal and their fetuses was increased significantly in the low folic-CBO group than high folic acid-CBO group. These results show that the low folate dietary diet with the exposure to
the high levels of CBO toxic material in pregnant women significantly increases the developmental and mutagenic toxicity in the
small fetuses.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
68
78
https://ejhm.journals.ekb.eg/article_18222_8330847ba9cfca2462aa928234e07894.pdf
dx.doi.org/10.21608/ejhm.2004.18222
Hepatic Iron In Type II Diabetes
Mahmoud M.
Bazid
Internal Medicine Departments, Al-Azhar
Faculty of Medicine.
author
Abd Al-Monem H.
Barrak
Internal Medicine Departments, Al-Azhar
Faculty of Medicine.
author
Hani
Abu Zeid
Internal Medicine Departments, Al-Azhar
Faculty of Medicine.
author
Mohamad Abd El-Aziz
Fahmy
BiochemistryDepartments, Al-Azhar
Faculty of Medicine.
author
Abd Ellah
Abu Srie
Biochemistry Departments, Al-Azhar
Faculty of Medicine.
author
text
article
2004
eng
The present work was carried on forty patients with type II diabetes of variable durations of the disease . They were selected from Internal Medicine Department, Sayed, Galal Al-Azhar University Hospital. They were 18 males and 22 females and their age ranged from 41 to 65 years. Twenty normal volunteer subjects were selected as a control group ( 9 males and 11 females and their age ranged from 45 to 65 years).
A full clinical evaluation was done. Labaratory investigations were also performed that included measurement of plasma fasting and postprandial glucose, urea, creatinine, alanine amino transferase (ALT), aspartate aminotransferase (AST) , bilirubin (total and direct), ANA, iron, ferritin, insulin ( fasting and postgrandial as well as hepatitis markers (HbsAg and HCVAb). Liver biopsy was taken for assessment of hepatic tissue iron concentration and histologic assessment. The results revealed that there is a significant difference between cases with type II diabetes and normal control as regarding insulin level (P<0.05). Also a significant relation was noted between high fasting insulin level and increased body mass index (BMI) especially above 30 . Also cases with type II diabetes with steatosis or steatohepatitis had significantly higher fasting insulin level than cases without ( P<0.05). Our results showed that there is a significant high hepatic iron concentration, serum ferritin and serum fasting insulin in patients compared with control group (P<0.05). Also there is a significant increase in HIC and serum ferritin among cases with longer duration of diabetes, together with significant increase in steatosis and steatohepatitis among those cases. In addition, elevated serum ferritin in female cases were of high significance (P<0.01) in comparison to significant elevation in male cases [P<0.05], this may be explained by the fact that females have higher BMI than males.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
79
85
https://ejhm.journals.ekb.eg/article_18223_da270029413901d00edebde5bd6b5812.pdf
dx.doi.org/10.21608/ejhm.2004.18223
Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice
Ameen A.
Ashour
Zoology Department, Ain-Shams University, Cairo, Egypt.
author
Samia A.
Ahmed
Therapeutical Chemistry Department, National Research Centre , Cairo, Egypt
author
Maghraby
A.S
Therapeutical Chemistry Department, National Research Centre , Cairo, Egypt
author
Zahran
H. G
Therapeutical Chemistry Department, National Research Centre , Cairo, Egypt
author
text
article
2004
eng
B This study aimed to detect the cellular, humoral immune responses and protection against schistosomes induced by cercarial (CAP), soluble worm (SWAP), soluble egg (SEA), and mixed (SEA + CAP), (SEA + SWAP) and (CAP + SWAP) antigens to Schistosoma mansoni infection in mice, and the improvement in the liver enzyme activities before and after challenge with S. mansoni. Each mouse was sensitized with an initial immunization of 0.6 ml of the extracted antigen (30μg protein/ml). After one week, a second injection of 0.4 ml was given (20μg protein/ml). Then, each mouse was exposed to 80 cercariae. Six weeks post challenge the protection percentage was 42.5, 58.33, 53.33, 60.91, 78.16 and 64.77% for CAP, SEA, SWAP, (SEA +CAP), (SEA+SWAP) and (CAP + SWAP), respectively. The results revealed a high significant interrelation between number of lymph node cells (MLN) (P0.001), splenocytes (P0.04) and thymocytes (P0.001) that obtained with each immunized group compared to controls. A high significant difference (P0.001) between levels of IgG obtained between different antigen groups and the control before and after challenge. The immunization with previous antigens resulted in a remarkable improvement in the liver enzyme activities, which were disturbed after infection. Thus, vaccination of mice with the previous different antigens has an immunoprophylactic effect and may protect liver against infection through reduction in worm burden leading to the improvement of many liver enzymes.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
86
103
https://ejhm.journals.ekb.eg/article_18224_b9458fd606dbe48426b4615522780ae9.pdf
dx.doi.org/10.21608/ejhm.2004.18224
Prophylactic effect of tamoxifen against induction of mammary carcinoma
Gabri
MS
Department of Zoology, faculty of science, Helwan University
author
Osman
AM
Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University
author
El-Sayed
MM
Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University
author
Negm
Somaia.A
Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University
author
text
article
2004
eng
Tamoxifen (TAM) is a potent anticancer agent known to interrupt the enhanced estrogen activity of malignant mammary gland cells, The mechanism of tamoxifen’s anti-tumor activity is primarily due to its anti estrogen action. Female Swiss albino mice were used in the present study and divided into:- normal control group, two Ehrlich ascites carcinoma (EAC) control groups [treated interaperitonealy(IP) and subcutaneously (Sc)], tamoxifen treated only group, tamoxifen pre treated then EAC (S.C) injected group and tamoxifen pre treated then EAC (I.P) injected group.
The present results showed a significant decrease in tumor volume and a significant increase in the survival time in the pre-treated group compared to untreated group. There was a pathological change in the uterine tissues of the tamoxifen treated mice in the form of squamous metaplasia and dysplasia of glandular epithelial . The kidney tissues showed a minimal pathological change in the form of a focal renal lesion in the renal tubular epithelium. in conclusion the present study showed that tamoxifen has a prophylactic effect against experimental mammary carcinoma. And exerts some side effects on the histopathological structure of the uterine and kidney tissues. Key words: Tamoxifen, Mammary carcinoma, experimental, prophylactic, side effect.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
104
114
https://ejhm.journals.ekb.eg/article_18225_d55e49f6ed7efa64b6d105036d51512f.pdf
dx.doi.org/10.21608/ejhm.2004.18225
Therapeutic effect of lycopene-rich tomato juice on cardiac disorder in rats fed on fried food in oxidized frying oil
Hassan
H. A
Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
author
Edrees
G. M.
Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
author
text
article
2004
eng
Therapeutic effect of lycopene-rich tomato juice against evoked cardiac disorders in rats fed on fried potato in oxidized frying cotton seed oil (20% w/w ) for 4-weeks was studied using lycopene at a daily dose of 1 mg/Kg body weight.
Total lipids, total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) were estimated in different animal groups. Lactic dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as well as serum calcium, potassium and magnesium were determined
The obtained results revealed that, feeding on fried potato in deep oxidized frying oil induced a notable increase in lipid profils and LDL-c associated with a marked elevation in specific heart enzymes, LDL, CK, ALT and AST activities. These biochemical alterations ameliorated when lycopene was administered to rats fed fried potato in oxidized frying oil.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
14
v.
1
no.
2004
115
126
https://ejhm.journals.ekb.eg/article_18226_9269904470ca3dbc727007a8e5e15759.pdf
dx.doi.org/10.21608/ejhm.2004.18226